SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pth'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_C_BEZC5013_0
(CES1 PROTEIN)		 2pth PEPTIDYL-TRNA
HYDROLASE
(Escherichia
coli) 		5 / 8 GLY A  23
GLY A   7
ALA A  91
LEU A  61
ILE A 119
 None
 0.99A 1yajC-2pthA:
undetectable		 1yajC-2pthA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2pth PEPTIDYL-TRNA
HYDROLASE
(Escherichia
coli) 		4 / 5 ASP A  93
GLY A 151
PRO A 139
ILE A 136
 None
 0.97A 2aoiA-2pthA:
undetectable		 2aoiA-2pthA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		 2pth PEPTIDYL-TRNA
HYDROLASE
(Escherichia
coli) 		3 / 3 LEU A  30
LEU A   4
PHE A  26
 None
 0.73A 2pgrA-2pthA:
undetectable		 2pgrA-2pthA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 2pth PEPTIDYL-TRNA
HYDROLASE
(Escherichia
coli) 		4 / 7 ALA A 164
ALA A 168
THR A 172
LEU A  89
 None
 0.94A 2wx2A-2pthA:
undetectable		 2wx2A-2pthA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 2pth PEPTIDYL-TRNA
HYDROLASE
(Escherichia
coli) 		4 / 8 ALA A 164
ALA A 168
THR A 172
LEU A  89
 None
 0.95A 2wx2B-2pthA:
undetectable		 2wx2B-2pthA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1413_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 2pth PEPTIDYL-TRNA
HYDROLASE
(Escherichia
coli) 		4 / 6 ALA A 164
ALA A 168
THR A 172
PHE A 104
 None
 0.86A 2xfhA-2pthA:
undetectable		 2xfhA-2pthA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFX_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 2pth PEPTIDYL-TRNA
HYDROLASE
(Escherichia
coli) 		5 / 8 LEU A  61
ALA A  73
GLY A   7
LEU A   8
GLY A 115
 None
 1.14A 2yfxA-2pthA:
undetectable		 2yfxA-2pthA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2pth PEPTIDYL-TRNA
HYDROLASE
(Escherichia
coli) 		5 / 10 ILE A   2
ILE A   5
VAL A  27
GLY A  23
VAL A  74
 None
 1.17A 3em0A-2pthA:
undetectable		 3em0A-2pthA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_2
(PROTEASE)		 2pth PEPTIDYL-TRNA
HYDROLASE
(Escherichia
coli) 		5 / 12 LEU A  95
GLY A  23
LEU A   8
VAL A 149
ILE A 136
 None
 0.93A 3em6B-2pthA:
undetectable		 3em6B-2pthA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KHM_A_TPFA501_1
(STEROL 14
ALPHA-DEMETHYLASE)		 2pth PEPTIDYL-TRNA
HYDROLASE
(Escherichia
coli) 		4 / 8 ALA A 164
ALA A 168
THR A 172
LEU A  89
 None
 0.88A 3khmA-2pthA:
undetectable		 3khmA-2pthA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_A_TPFA490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 2pth PEPTIDYL-TRNA
HYDROLASE
(Escherichia
coli) 		4 / 8 ALA A 164
ALA A 168
THR A 172
LEU A  89
 None
 0.90A 3l4dA-2pthA:
undetectable		 3l4dA-2pthA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_D_TPFD490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 2pth PEPTIDYL-TRNA
HYDROLASE
(Escherichia
coli) 		4 / 8 ALA A 164
ALA A 168
THR A 172
LEU A  89
 None
 0.88A 3l4dD-2pthA:
undetectable		 3l4dD-2pthA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_A_BEZA1000_0
(BENZOATE-COENZYME A
LIGASE)		 2pth PEPTIDYL-TRNA
HYDROLASE
(Escherichia
coli) 		4 / 7 ALA A 102
ALA A  22
GLY A  23
ILE A 161
 None
 0.56A 4eatA-2pthA:
undetectable		 4eatA-2pthA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		 2pth PEPTIDYL-TRNA
HYDROLASE
(Escherichia
coli) 		3 / 3 LYS A 122
ASN A 128
ASP A 118
 None
 0.74A 4o1eA-2pthA:
undetectable		 4o1eA-2pthA:
22.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QD3_A_5AEA201_1
(PEPTIDYL-TRNA
HYDROLASE)		 2pth PEPTIDYL-TRNA
HYDROLASE
(Escherichia
coli) 		8 / 9 HIS A  20
LEU A  95
GLY A 112
HIS A 113
ASN A 114
VAL A 145
VAL A 149
LEU A 150
 None
 0.43A 4qd3A-2pthA:
33.7		 4qd3A-2pthA:
59.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 2pth PEPTIDYL-TRNA
HYDROLASE
(Escherichia
coli) 		5 / 12 LEU A  95
PHE A 148
ARG A  19
ILE A 161
LEU A 132
 None
 1.26A 5ljcA-2pthA:
undetectable		 5ljcA-2pthA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_A_ACTA802_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 2pth PEPTIDYL-TRNA
HYDROLASE
(Escherichia
coli) 		4 / 6 HIS A  20
ASP A  93
HIS A 113
MET A  67
 None
 1.49A 5m45A-2pthA:
0.0		 5m45A-2pthA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_D_ACTD802_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 2pth PEPTIDYL-TRNA
HYDROLASE
(Escherichia
coli) 		4 / 6 HIS A  20
ASP A  93
HIS A 113
MET A  67
 None
 1.49A 5m45D-2pthA:
0.0		 5m45D-2pthA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_G_ACTG802_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 2pth PEPTIDYL-TRNA
HYDROLASE
(Escherichia
coli) 		4 / 6 HIS A  20
ASP A  93
HIS A 113
MET A  67
 None
 1.49A 5m45G-2pthA:
0.0		 5m45G-2pthA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_J_ACTJ802_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 2pth PEPTIDYL-TRNA
HYDROLASE
(Escherichia
coli) 		4 / 6 HIS A  20
ASP A  93
HIS A 113
MET A  67
 None
 1.49A 5m45J-2pthA:
0.0		 5m45J-2pthA:
15.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y9A_A_AR3A201_1
(PEPTIDYL-TRNA
HYDROLASE)		 2pth PEPTIDYL-TRNA
HYDROLASE
(Escherichia
coli) 		4 / 6 ALA A  16
TRP A  25
GLN A 158
ASP A 162
 None
 0.24A 5y9aA-2pthA:
32.7		 5y9aA-2pthA:
52.02