SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ptm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2ptm HYPERPOLARIZATION-AC
TIVATED (IH) CHANNEL
(Strongylocentrot
us
purpuratus) 		4 / 5 PHE A 545
PHE A 584
MET A 582
SER A 636
 None
 1.32A 1wrkB-2ptmA:
undetectable		 1wrkB-2ptmA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_B_NCAB1246_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 2ptm HYPERPOLARIZATION-AC
TIVATED (IH) CHANNEL
(Strongylocentrot
us
purpuratus) 		4 / 7 GLY A 610
SER A 634
ARG A 620
GLU A 564
 CMP  A 401 (-3.2A)
None
CMP  A 401 (-4.0A)
None
 0.93A 2c8aB-2ptmA:
undetectable		 2c8aB-2ptmA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_ACTA148_0
(UPF0066 PROTEIN
AF_0241)		 2ptm HYPERPOLARIZATION-AC
TIVATED (IH) CHANNEL
(Strongylocentrot
us
purpuratus) 		3 / 3 VAL A 659
GLU A 655
GLU A 656
 None
 0.80A 2nv4A-2ptmA:
undetectable		 2nv4A-2ptmA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2ptm HYPERPOLARIZATION-AC
TIVATED (IH) CHANNEL
(Strongylocentrot
us
purpuratus) 		4 / 8 TYR A 477
LEU A 481
VAL A 484
GLU A 485
 None
 0.80A 4fgzA-2ptmA:
undetectable		 4fgzA-2ptmA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2ptm HYPERPOLARIZATION-AC
TIVATED (IH) CHANNEL
(Strongylocentrot
us
purpuratus) 		4 / 8 TYR A 477
LEU A 481
VAL A 484
GLU A 485
 None
 0.78A 4fgzB-2ptmA:
undetectable		 4fgzB-2ptmA:
20.96