SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pts'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FIQ_C_SALC1335_1
(XANTHINE OXIDASE)		 2pts ADENYLOSUCCINATE
LYASE
(Escherichia
coli) 		4 / 8 LEU A 135
VAL A 261
LEU A 321
ALA A 325
 None
 0.90A 1fiqC-2ptsA:
undetectable		 1fiqC-2ptsA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK6_A_LNLA1201_1
(NON-SPECIFIC LIPID
TRANSFER PROTEIN)		 2pts ADENYLOSUCCINATE
LYASE
(Escherichia
coli) 		5 / 12 VAL A  41
LEU A  44
ALA A  48
LEU A 110
ILE A  70
 None
 0.87A 1fk6A-2ptsA:
undetectable		 1fk6A-2ptsA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2pts ADENYLOSUCCINATE
LYASE
(Escherichia
coli) 		5 / 12 THR A 246
ASP A 336
THR A 338
LYS A 327
HIS A 251
 None
 1.48A 1v8bB-2ptsA:
undetectable		 1v8bB-2ptsA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		 2pts ADENYLOSUCCINATE
LYASE
(Escherichia
coli) 		5 / 12 LEU A 135
ILE A 350
ASN A 318
LEU A 321
LEU A 324
 None
 0.96A 2bdmA-2ptsA:
1.9		 2bdmA-2ptsA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		 2pts ADENYLOSUCCINATE
LYASE
(Escherichia
coli) 		6 / 12 PHE A  27
LEU A 198
ILE A 143
ILE A 350
ASN A 318
LEU A 321
 None
 1.15A 2bdmA-2ptsA:
1.9		 2bdmA-2ptsA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		 2pts ADENYLOSUCCINATE
LYASE
(Escherichia
coli) 		4 / 8 VAL A 369
LEU A 367
VAL A 364
VAL A 187
 None
 1.02A 2bdmA-2ptsA:
1.9		 2bdmA-2ptsA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 2pts ADENYLOSUCCINATE
LYASE
(Escherichia
coli) 		4 / 7 VAL A 234
SER A 230
LEU A 204
THR A 245
 None
 0.89A 2f78A-2ptsA:
undetectable		 2f78A-2ptsA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1004_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 2pts ADENYLOSUCCINATE
LYASE
(Escherichia
coli) 		4 / 7 VAL A 234
SER A 230
LEU A 204
THR A 245
 None
 0.99A 2f78B-2ptsA:
undetectable		 2f78B-2ptsA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 2pts ADENYLOSUCCINATE
LYASE
(Escherichia
coli) 		5 / 12 THR A 246
ASP A 336
THR A 338
LYS A 327
HIS A 251
 None
 1.50A 3ce6D-2ptsA:
undetectable		 3ce6D-2ptsA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 2pts ADENYLOSUCCINATE
LYASE
(Escherichia
coli) 		5 / 12 THR A 246
ASP A 336
THR A 338
LYS A 327
HIS A 251
 None
 1.42A 3n58C-2ptsA:
undetectable		 3n58C-2ptsA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 2pts ADENYLOSUCCINATE
LYASE
(Escherichia
coli) 		5 / 12 THR A 246
ASP A 336
THR A 338
LYS A 327
HIS A 251
 None
 1.45A 3n58D-2ptsA:
undetectable		 3n58D-2ptsA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_A_ADNA506_1
(ADENOSYLHOMOCYSTEINA
SE)		 2pts ADENYLOSUCCINATE
LYASE
(Escherichia
coli) 		5 / 12 THR A 246
ASP A 336
THR A 338
LYS A 327
HIS A 251
 None
 1.47A 3ondA-2ptsA:
undetectable		 3ondA-2ptsA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_B_ADNB507_1
(ADENOSYLHOMOCYSTEINA
SE)		 2pts ADENYLOSUCCINATE
LYASE
(Escherichia
coli) 		5 / 12 THR A 246
ASP A 336
THR A 338
LYS A 327
HIS A 251
 None
 1.50A 3ondB-2ptsA:
undetectable		 3ondB-2ptsA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JJK_A_FOLA601_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 2pts ADENYLOSUCCINATE
LYASE
(Escherichia
coli) 		4 / 8 ASN A 309
ALA A 356
LEU A 268
LEU A 314
 None
 0.91A 4jjkA-2ptsA:
undetectable		 4jjkA-2ptsA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 2pts ADENYLOSUCCINATE
LYASE
(Escherichia
coli) 		4 / 8 SER A 331
ASP A 336
VAL A 342
THR A 341
 None
 1.15A 4lnwA-2ptsA:
undetectable		 4lnwA-2ptsA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_2
(ANDROGEN RECEPTOR)		 2pts ADENYLOSUCCINATE
LYASE
(Escherichia
coli) 		4 / 7 ASN A 345
LEU A 135
LEU A  32
ILE A 350
 None
 0.92A 4okwA-2ptsA:
undetectable		 4okwA-2ptsA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_E_ACTE403_0
(PROTON-GATED ION
CHANNEL)		 2pts ADENYLOSUCCINATE
LYASE
(Escherichia
coli) 		3 / 3 ARG A 435
TYR A 396
GLU A 432
 None
 0.29A 4zzbE-2ptsA:
2.8		 4zzbE-2ptsA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_2
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 2pts ADENYLOSUCCINATE
LYASE
(Escherichia
coli) 		4 / 4 VAL A  12
ILE A 350
ASN A 345
VAL A 320
 None
 1.33A 5ajqA-2ptsA:
undetectable		 5ajqA-2ptsA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_2
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 2pts ADENYLOSUCCINATE
LYASE
(Escherichia
coli) 		4 / 4 VAL A 320
ILE A 350
ASN A 313
VAL A  12
 None
 1.23A 5ajqA-2ptsA:
undetectable		 5ajqA-2ptsA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2pts ADENYLOSUCCINATE
LYASE
(Escherichia
coli) 		5 / 12 THR A 246
ASP A 336
THR A 338
LYS A 327
HIS A 251
 None
 1.49A 5axdA-2ptsA:
undetectable		 5axdA-2ptsA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2pts ADENYLOSUCCINATE
LYASE
(Escherichia
coli) 		5 / 12 THR A 246
ASP A 336
THR A 338
LYS A 327
HIS A 251
 None
 1.48A 5axdC-2ptsA:
undetectable		 5axdC-2ptsA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_A_SAMA601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 2pts ADENYLOSUCCINATE
LYASE
(Escherichia
coli) 		5 / 12 GLU A  76
LEU A  32
ILE A  82
VAL A  37
VAL A  96
 None
 1.05A 5dpdA-2ptsA:
2.1		 5dpdA-2ptsA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_A_SAMA601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 2pts ADENYLOSUCCINATE
LYASE
(Escherichia
coli) 		5 / 12 GLU A 249
GLY A 205
GLN A 240
ILE A 207
VAL A  39
 None
 0.97A 5dpdA-2ptsA:
2.1		 5dpdA-2ptsA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 2pts ADENYLOSUCCINATE
LYASE
(Escherichia
coli) 		3 / 3 LYS A  34
ASP A  78
ILE A 126
 None
 0.89A 5kc4E-2ptsA:
2.9		 5kc4E-2ptsA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2pts ADENYLOSUCCINATE
LYASE
(Escherichia
coli) 		5 / 12 THR A 246
ASP A 336
THR A 338
LYS A 327
HIS A 251
 None
 1.48A 5m66C-2ptsA:
undetectable		 5m66C-2ptsA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_C_SAMC501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2pts ADENYLOSUCCINATE
LYASE
(Escherichia
coli) 		4 / 7 GLY A  31
GLY A  25
SER A  73
ALA A  79
 None
 0.79A 5o96C-2ptsA:
undetectable		 5o96C-2ptsA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_B_ADNB505_1
(-)		 2pts ADENYLOSUCCINATE
LYASE
(Escherichia
coli) 		5 / 12 THR A 246
ASP A 336
THR A 338
LYS A 327
HIS A 251
 None
 1.44A 6f3nB-2ptsA:
undetectable		 6f3nB-2ptsA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_Q_PCFQ202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2pts ADENYLOSUCCINATE
LYASE
(Escherichia
coli) 		4 / 6 TYR A 357
ILE A 143
ALA A 262
ASP A 272
 None
 1.09A 6hu9m-2ptsA:
2.2
6hu9q-2ptsA:
0.2		 6hu9m-2ptsA:
21.52
6hu9q-2ptsA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_B_H98B501_0
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)		 2pts ADENYLOSUCCINATE
LYASE
(Escherichia
coli) 		5 / 12 THR A 360
VAL A 364
ASP A 270
PHE A 271
PHE A 284
 None
 1.37A 6iblB-2ptsA:
3.5		 6iblB-2ptsA:
23.27