SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ptz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2ptz ENOLASE
(Trypanosoma
brucei) 		5 / 12 ILE A 116
ALA A 119
ALA A 120
LEU A  83
LEU A 135
 None
 0.90A 1fm9A-2ptzA:
undetectable		 1fm9A-2ptzA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_1
(HIV-II PROTEASE)		 2ptz ENOLASE
(Trypanosoma
brucei) 		6 / 12 GLY A 199
ALA A 202
ASP A 201
PRO A 221
ILE A 224
ILE A 194
 None
 1.46A 1hshA-2ptzA:
undetectable		 1hshA-2ptzA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2ptz ENOLASE
(Trypanosoma
brucei) 		5 / 12 ILE A 116
ALA A 119
ALA A 120
LEU A  83
LEU A 135
 None
 0.86A 1k74A-2ptzA:
undetectable		 1k74A-2ptzA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_A_KANA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 2ptz ENOLASE
(Trypanosoma
brucei) 		5 / 8 GLU A 208
GLY A 396
SER A 370
ASP A 318
ASP A 243
 PAH  A 600 ( 4.8A)
None
PAH  A 600 ( 4.2A)
ZN  A 500 ( 3.0A)
ZN  A 500 ( 2.4A)
 1.50A 1m4iA-2ptzA:
undetectable		 1m4iA-2ptzA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2ptz ENOLASE
(Trypanosoma
brucei) 		5 / 12 ALA A 246
ILE A 287
LEU A 222
PRO A 223
THR A 249
 None
 1.06A 1rx8A-2ptzA:
undetectable		 1rx8A-2ptzA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		 2ptz ENOLASE
(Trypanosoma
brucei) 		5 / 6 SER A 113
ILE A 350
ALA A 353
THR A 323
ALA A  46
 None
 1.08A 1w0gA-2ptzA:
undetectable		 1w0gA-2ptzA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_B_9CRB202_1
(RXR-LIKE PROTEIN)		 2ptz ENOLASE
(Trypanosoma
brucei) 		5 / 12 ILE A 116
ALA A 119
ALA A 120
LEU A  83
LEU A 135
 None
 0.89A 1xiuB-2ptzA:
undetectable		 1xiuB-2ptzA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_A_9CRA801_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2ptz ENOLASE
(Trypanosoma
brucei) 		5 / 12 ILE A 116
ALA A 119
ALA A 120
LEU A  83
LEU A 135
 None
 0.85A 1xlsA-2ptzA:
undetectable		 1xlsA-2ptzA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_B_9CRB802_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2ptz ENOLASE
(Trypanosoma
brucei) 		5 / 12 ILE A 116
ALA A 119
ALA A 120
LEU A  83
LEU A 135
 None
 0.85A 1xlsB-2ptzA:
undetectable		 1xlsB-2ptzA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_C_9CRC803_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2ptz ENOLASE
(Trypanosoma
brucei) 		5 / 12 ILE A 116
ALA A 119
ALA A 120
LEU A  83
LEU A 135
 None
 0.85A 1xlsC-2ptzA:
undetectable		 1xlsC-2ptzA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_D_9CRD804_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2ptz ENOLASE
(Trypanosoma
brucei) 		5 / 12 ILE A 116
ALA A 119
ALA A 120
LEU A  83
LEU A 135
 None
 0.85A 1xlsD-2ptzA:
undetectable		 1xlsD-2ptzA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_B_IBPB2002_1
(SERUM ALBUMIN)		 2ptz ENOLASE
(Trypanosoma
brucei) 		5 / 10 ALA A 353
LEU A 132
LEU A 384
ALA A 387
VAL A 369
 None
 1.02A 2bxgB-2ptzA:
undetectable		 2bxgB-2ptzA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2ptz ENOLASE
(Trypanosoma
brucei) 		3 / 3 LEU A 222
PRO A 221
LEU A 225
 None
 0.57A 2po5B-2ptzA:
undetectable		 2po5B-2ptzA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2ptz ENOLASE
(Trypanosoma
brucei) 		4 / 8 THR A 313
TYR A 294
TYR A 278
CYH A 279
 None
 1.18A 2xz5A-2ptzA:
undetectable
2xz5C-2ptzA:
undetectable		 2xz5A-2ptzA:
19.91
2xz5C-2ptzA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 2ptz ENOLASE
(Trypanosoma
brucei) 		3 / 3 SER A  37
GLU A 248
ASP A 295
 None
 0.83A 2zulA-2ptzA:
undetectable		 2zulA-2ptzA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_C_AG2C1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 2ptz ENOLASE
(Trypanosoma
brucei) 		4 / 8 HIS A 371
SER A 373
ASP A 243
ASP A 318
 None
PAH  A 600 (-2.4A)
ZN  A 500 ( 2.4A)
ZN  A 500 ( 3.0A)
 1.27A 3n2oC-2ptzA:
6.8
3n2oD-2ptzA:
3.3		 3n2oC-2ptzA:
21.04
3n2oD-2ptzA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2ptz ENOLASE
(Trypanosoma
brucei) 		5 / 11 LEU A 110
TYR A 380
ILE A 350
ALA A 353
LEU A 342
 None
 1.11A 3n8yA-2ptzA:
undetectable		 3n8yA-2ptzA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2ptz ENOLASE
(Trypanosoma
brucei) 		3 / 3 TYR A  44
ASP A 295
ASP A 251
 None
 0.56A 3ou6B-2ptzA:
undetectable		 3ou6B-2ptzA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2ptz ENOLASE
(Trypanosoma
brucei) 		4 / 7 ASP A 318
ASN A 345
GLU A  48
GLU A 375
 ZN  A 500 ( 3.0A)
None
None
None
 1.21A 4fewB-2ptzA:
undetectable		 4fewB-2ptzA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2ptz ENOLASE
(Trypanosoma
brucei) 		4 / 8 ASP A 318
ASN A 345
GLU A  48
GLU A 375
 ZN  A 500 ( 3.0A)
None
None
None
 1.19A 4gkhD-2ptzA:
undetectable		 4gkhD-2ptzA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 2ptz ENOLASE
(Trypanosoma
brucei) 		5 / 12 LEU A 340
LEU A 341
ILE A 381
ILE A 393
LEU A 388
 None
PAH  A 600 (-4.8A)
None
None
None
 1.30A 4j26B-2ptzA:
undetectable		 4j26B-2ptzA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		 2ptz ENOLASE
(Trypanosoma
brucei) 		5 / 12 LEU A 222
LEU A 259
PHE A 163
ASP A 243
ASP A 292
 None
None
None
ZN  A 500 ( 2.4A)
ZN  A 500 ( 4.9A)
 1.33A 4j7xJ-2ptzA:
undetectable		 4j7xJ-2ptzA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2ptz ENOLASE
(Trypanosoma
brucei) 		4 / 5 LEU A 222
PRO A 221
LEU A 225
ILE A 240
 None
 1.02A 4klrA-2ptzA:
undetectable		 4klrA-2ptzA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T44A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 2ptz ENOLASE
(Trypanosoma
brucei) 		4 / 6 SER A 366
GLN A 392
VAL A 288
THR A 313
 None
 1.31A 4lnxA-2ptzA:
undetectable		 4lnxA-2ptzA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 2ptz ENOLASE
(Trypanosoma
brucei) 		4 / 8 ARG A 403
ASP A 207
ALA A  39
SER A  40
 None
None
PAH  A 600 (-3.6A)
ZN  A 501 ( 2.1A)
 1.00A 4lv9A-2ptzA:
2.9
4lv9B-2ptzA:
3.5		 4lv9A-2ptzA:
22.33
4lv9B-2ptzA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 2ptz ENOLASE
(Trypanosoma
brucei) 		4 / 5 ASN A 159
ALA A 157
GLY A 153
ASP A 251
 None
 0.93A 4n48A-2ptzA:
undetectable		 4n48A-2ptzA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_2
(NUPC FAMILY PROTEIN)		 2ptz ENOLASE
(Trypanosoma
brucei) 		3 / 3 THR A 277
ASN A 258
PHE A 261
 None
 0.74A 4pd9A-2ptzA:
undetectable		 4pd9A-2ptzA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDC_A_ASDA404_1
(3-KETOSTEROID
9ALPHA-HYDROXYLASE
OXYGENASE)		 2ptz ENOLASE
(Trypanosoma
brucei) 		5 / 12 VAL A 322
LEU A  93
ALA A  46
LEU A 110
ASN A 345
 None
 1.48A 4qdcA-2ptzA:
undetectable		 4qdcA-2ptzA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		 2ptz ENOLASE
(Trypanosoma
brucei) 		5 / 12 ASP A 378
ILE A 344
ALA A 353
ILE A 350
SER A 117
 None
 1.28A 4uroC-2ptzA:
undetectable		 4uroC-2ptzA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_2
(TUBULIN BETA CHAIN)		 2ptz ENOLASE
(Trypanosoma
brucei) 		5 / 12 LEU A 128
ALA A 387
LEU A 384
ALA A 353
ILE A 344
 None
 1.28A 5eypB-2ptzA:
undetectable		 5eypB-2ptzA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS5_A_ASCA202_0
(CYTOCHROME C')		 2ptz ENOLASE
(Trypanosoma
brucei) 		3 / 3 CYH A 279
LYS A 280
HIS A 283
 None
 0.56A 5js5A-2ptzA:
undetectable		 5js5A-2ptzA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_A_ACTA701_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 2ptz ENOLASE
(Trypanosoma
brucei) 		3 / 3 LYS A 216
LYS A 262
SER A 263
 None
 1.27A 5odiA-2ptzA:
undetectable		 5odiA-2ptzA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_1
(CYTOCHROME P450 3A5)		 2ptz ENOLASE
(Trypanosoma
brucei) 		5 / 12 SER A 113
ILE A 350
ALA A 353
THR A 323
ALA A  46
 None
 1.09A 5veuA-2ptzA:
undetectable		 5veuA-2ptzA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VYH_A_FOLA409_0
(S PROTEIN)		 2ptz ENOLASE
(Trypanosoma
brucei) 		5 / 10 PRO A 170
ALA A 228
GLY A 192
ILE A 193
ALA A 232
 None
 1.25A 5vyhA-2ptzA:
undetectable		 5vyhA-2ptzA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2ptz ENOLASE
(Trypanosoma
brucei) 		5 / 12 ILE A 116
ALA A 119
ALA A 120
LEU A  83
LEU A 135
 None
 0.97A 5z12B-2ptzA:
undetectable		 5z12B-2ptzA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 2ptz ENOLASE
(Trypanosoma
brucei) 		3 / 3 LYS A 118
LEU A 110
ASP A 378
 None
 0.84A 5zv2A-2ptzA:
undetectable		 5zv2A-2ptzA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A60_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2ptz ENOLASE
(Trypanosoma
brucei) 		5 / 12 ILE A 116
ALA A 119
ALA A 120
LEU A  83
LEU A 135
 None
 0.89A 6a60D-2ptzA:
undetectable		 6a60D-2ptzA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		 2ptz ENOLASE
(Trypanosoma
brucei) 		4 / 6 SER A 113
ALA A 353
THR A 323
ALA A  46
 None
 0.95A 6ma6A-2ptzA:
undetectable		 6ma6A-2ptzA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA7_A_TPFA602_0
(CYTOCHROME P450 3A4)		 2ptz ENOLASE
(Trypanosoma
brucei) 		4 / 7 SER A 113
ALA A 353
THR A 323
ALA A  46
 None
 0.93A 6ma7A-2ptzA:
undetectable		 6ma7A-2ptzA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_B_FOZB401_0
(THYMIDYLATE SYNTHASE)		 2ptz ENOLASE
(Trypanosoma
brucei) 		5 / 12 LEU A 259
ILE A 218
LEU A 225
GLY A 153
ILE A 215
 None
 1.25A 6qyaB-2ptzA:
undetectable		 6qyaB-2ptzA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_D_FOZD401_0
(THYMIDYLATE SYNTHASE)		 2ptz ENOLASE
(Trypanosoma
brucei) 		5 / 12 LEU A 259
ILE A 218
LEU A 225
GLY A 153
ILE A 215
 None
 1.25A 6qyaD-2ptzA:
undetectable		 6qyaD-2ptzA:
21.24