SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pun'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_2
(PROTEASE)		 2pun METHYLTHIORIBOSE
KINASE
(Bacillus
subtilis) 		4 / 6 ASP A 250
GLY A  39
ILE A  38
ILE A 122
 MG  A 401 ( 2.8A)
ACP  A 999 ( 4.1A)
None
ACP  A 999 (-4.5A)
 0.88A 1n49D-2punA:
undetectable		 1n49D-2punA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OMB_D_IPHD2002_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 2pun METHYLTHIORIBOSE
KINASE
(Bacillus
subtilis) 		4 / 7 HIS A 244
TYR A 133
HIS A 135
PRO A 134
 None
 1.28A 2ombC-2punA:
undetectable
2ombD-2punA:
undetectable		 2ombC-2punA:
18.52
2ombD-2punA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_A_ACTA501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 2pun METHYLTHIORIBOSE
KINASE
(Bacillus
subtilis) 		4 / 7 ASP A 278
ARG A 282
ARG A 363
ILE A 354
 None
 1.13A 2yfbA-2punA:
undetectable		 2yfbA-2punA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_B_ACTB501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 2pun METHYLTHIORIBOSE
KINASE
(Bacillus
subtilis) 		4 / 6 ASP A 278
ARG A 282
ARG A 363
ILE A 354
 None
 1.09A 2yfbB-2punA:
undetectable		 2yfbB-2punA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 2pun METHYLTHIORIBOSE
KINASE
(Bacillus
subtilis) 		5 / 11 THR A 342
ILE A 339
LYS A 204
LEU A 205
THR A 372
 None
 1.08A 3bexC-2punA:
undetectable
3bexD-2punA:
undetectable		 3bexC-2punA:
23.00
3bexD-2punA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 2pun METHYLTHIORIBOSE
KINASE
(Bacillus
subtilis) 		5 / 10 LYS A 204
LEU A 205
THR A 372
THR A 342
ILE A 339
 None
 1.11A 3bexC-2punA:
undetectable
3bexD-2punA:
undetectable		 3bexC-2punA:
23.00
3bexD-2punA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 2pun METHYLTHIORIBOSE
KINASE
(Bacillus
subtilis) 		5 / 10 THR A 342
ILE A 339
LYS A 204
LEU A 205
THR A 372
 None
 1.09A 3bexE-2punA:
undetectable
3bexF-2punA:
undetectable		 3bexE-2punA:
23.00
3bexF-2punA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_A_PAUA248_0
(TYPE III
PANTOTHENATE KINASE)		 2pun METHYLTHIORIBOSE
KINASE
(Bacillus
subtilis) 		5 / 11 THR A 342
ILE A 339
LYS A 204
LEU A 205
THR A 372
 None
 1.11A 3bf1A-2punA:
undetectable
3bf1B-2punA:
undetectable		 3bf1A-2punA:
23.00
3bf1B-2punA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_B_PAUB248_0
(TYPE III
PANTOTHENATE KINASE)		 2pun METHYLTHIORIBOSE
KINASE
(Bacillus
subtilis) 		5 / 12 LYS A 204
LEU A 205
THR A 372
THR A 342
ILE A 339
 None
 1.13A 3bf1A-2punA:
undetectable
3bf1B-2punA:
undetectable		 3bf1A-2punA:
23.00
3bf1B-2punA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 2pun METHYLTHIORIBOSE
KINASE
(Bacillus
subtilis) 		5 / 11 THR A 342
ILE A 339
LYS A 204
LEU A 205
THR A 372
 None
 1.12A 3bf1C-2punA:
undetectable
3bf1D-2punA:
undetectable		 3bf1C-2punA:
23.00
3bf1D-2punA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 2pun METHYLTHIORIBOSE
KINASE
(Bacillus
subtilis) 		5 / 11 LYS A 204
LEU A 205
THR A 372
THR A 342
ILE A 339
 None
 1.17A 3bf1C-2punA:
undetectable
3bf1D-2punA:
undetectable		 3bf1C-2punA:
23.00
3bf1D-2punA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 2pun METHYLTHIORIBOSE
KINASE
(Bacillus
subtilis) 		5 / 11 THR A 342
ILE A 339
LYS A 204
LEU A 205
THR A 372
 None
 1.11A 3bf1E-2punA:
1.1
3bf1F-2punA:
undetectable		 3bf1E-2punA:
23.00
3bf1F-2punA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 2pun METHYLTHIORIBOSE
KINASE
(Bacillus
subtilis) 		5 / 11 LYS A 204
LEU A 205
THR A 372
THR A 342
ILE A 339
 None
 1.15A 3bf1E-2punA:
1.1
3bf1F-2punA:
undetectable		 3bf1E-2punA:
23.00
3bf1F-2punA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZJ_A_ACRA405_1
(ACARBOSE/MALTOSE
BINDING PROTEIN GACH)		 2pun METHYLTHIORIBOSE
KINASE
(Bacillus
subtilis) 		5 / 12 GLU A 227
PHE A 261
GLY A 232
ALA A 268
GLY A 332
 None
 1.19A 3jzjA-2punA:
undetectable		 3jzjA-2punA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_B_CL6B506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2pun METHYLTHIORIBOSE
KINASE
(Bacillus
subtilis) 		5 / 12 LEU A 144
PHE A 296
ILE A 326
GLU A 329
ALA A 334
 None
 0.98A 3mdvB-2punA:
undetectable		 3mdvB-2punA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDI_A_SAMA601_0
(METHYLTRANSFERASE)		 2pun METHYLTHIORIBOSE
KINASE
(Bacillus
subtilis) 		5 / 12 PHE A 296
ILE A 230
PHE A 168
PHE A 255
THR A 228
 None
 1.34A 3ndiA-2punA:
undetectable		 3ndiA-2punA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_0
(GLYCINE
N-METHYLTRANSFERASE)		 2pun METHYLTHIORIBOSE
KINASE
(Bacillus
subtilis) 		4 / 6 LEU A 270
HIS A 288
THR A 236
ARG A 124
 None
 1.29A 3thrB-2punA:
undetectable		 3thrB-2punA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAJ_B_0HKB2000_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 2pun METHYLTHIORIBOSE
KINASE
(Bacillus
subtilis) 		3 / 3 ASN A 207
LEU A 368
PHE A 187
 None
 0.75A 4dajB-2punA:
undetectable		 4dajB-2punA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 2pun METHYLTHIORIBOSE
KINASE
(Bacillus
subtilis) 		5 / 12 ALA A 155
TRP A 304
PHE A 300
PHE A 149
LEU A 144
 None
 1.28A 4ib4A-2punA:
undetectable		 4ib4A-2punA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2pun METHYLTHIORIBOSE
KINASE
(Bacillus
subtilis) 		4 / 6 ASN A 290
GLU A 283
TYR A 286
GLU A 389
 None
None
None
CPS  A 777 (-3.5A)
 1.00A 4mi4A-2punA:
undetectable		 4mi4A-2punA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2pun METHYLTHIORIBOSE
KINASE
(Bacillus
subtilis) 		4 / 7 ASN A 290
GLU A 283
TYR A 286
GLU A 389
 None
None
None
CPS  A 777 (-3.5A)
 1.00A 4mi4B-2punA:
undetectable
4mi4C-2punA:
undetectable		 4mi4B-2punA:
20.15
4mi4C-2punA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2pun METHYLTHIORIBOSE
KINASE
(Bacillus
subtilis) 		4 / 7 ASN A 290
GLU A 283
TYR A 286
GLU A 389
 None
None
None
CPS  A 777 (-3.5A)
 0.99A 4mi4A-2punA:
undetectable
4mi4C-2punA:
undetectable		 4mi4A-2punA:
20.15
4mi4C-2punA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2pun METHYLTHIORIBOSE
KINASE
(Bacillus
subtilis) 		4 / 8 ASN A 290
GLU A 283
TYR A 286
GLU A 389
 None
None
None
CPS  A 777 (-3.5A)
 0.99A 4mj8A-2punA:
undetectable
4mj8C-2punA:
undetectable		 4mj8A-2punA:
19.84
4mj8C-2punA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2pun METHYLTHIORIBOSE
KINASE
(Bacillus
subtilis) 		4 / 8 ASN A 290
GLU A 283
TYR A 286
GLU A 389
 None
None
None
CPS  A 777 (-3.5A)
 0.99A 4mj8B-2punA:
undetectable
4mj8C-2punA:
undetectable		 4mj8B-2punA:
19.84
4mj8C-2punA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2pun METHYLTHIORIBOSE
KINASE
(Bacillus
subtilis) 		4 / 7 ASN A 290
GLU A 283
TYR A 286
GLU A 389
 None
None
None
CPS  A 777 (-3.5A)
 0.98A 4mj8C-2punA:
undetectable		 4mj8C-2punA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_D_ACTD201_0
(RETINOL-BINDING
PROTEIN 2)		 2pun METHYLTHIORIBOSE
KINASE
(Bacillus
subtilis) 		3 / 3 ASP A 116
HIS A  48
LYS A  56
 ACP  A 999 (-4.6A)
None
None
 0.90A 4qzuD-2punA:
undetectable		 4qzuD-2punA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_I_SPMI202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2pun METHYLTHIORIBOSE
KINASE
(Bacillus
subtilis) 		4 / 7 ASN A 290
GLU A 283
TYR A 286
GLU A 389
 None
None
None
CPS  A 777 (-3.5A)
 1.07A 4r87I-2punA:
undetectable		 4r87I-2punA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_A_010A609_0
(HNL ISOENZYME 5)		 2pun METHYLTHIORIBOSE
KINASE
(Bacillus
subtilis) 		5 / 11 ALA A 123
ALA A 241
LEU A 136
LEU A 270
HIS A 288
 None
 1.33A 5eb5A-2punA:
undetectable		 5eb5A-2punA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		 2pun METHYLTHIORIBOSE
KINASE
(Bacillus
subtilis) 		4 / 8 SER A 238
ASP A 250
PRO A 251
PHE A 253
 None
MG  A 401 ( 2.8A)
None
SR1  A 998 (-4.3A)
 1.11A 5l1fA-2punA:
undetectable
5l1fB-2punA:
undetectable		 5l1fA-2punA:
19.53
5l1fB-2punA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND2_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 2pun METHYLTHIORIBOSE
KINASE
(Bacillus
subtilis) 		5 / 12 VAL A 263
ASP A 262
ALA A 330
ARG A 340
PRO A 258
 None
None
None
SR1  A 998 (-2.9A)
None
 1.39A 5nd2B-2punA:
undetectable		 5nd2B-2punA:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 2pun METHYLTHIORIBOSE
KINASE
(Bacillus
subtilis) 		4 / 8 VAL A  46
LYS A  61
ILE A 249
ASP A 250
 ACP  A 999 (-4.6A)
ACP  A 999 (-2.9A)
None
MG  A 401 ( 2.8A)
 0.73A 5y9mA-2punA:
9.0		 5y9mA-2punA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 2pun METHYLTHIORIBOSE
KINASE
(Bacillus
subtilis) 		4 / 8 VAL A  46
LYS A  61
ILE A 249
ASP A 250
 ACP  A 999 (-4.6A)
ACP  A 999 (-2.9A)
None
MG  A 401 ( 2.8A)
 0.68A 5y9mX-2punA:
9.2		 5y9mX-2punA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_B_NIOB401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 2pun METHYLTHIORIBOSE
KINASE
(Bacillus
subtilis) 		4 / 7 VAL A  46
LYS A  61
ILE A 249
ASP A 250
 ACP  A 999 (-4.6A)
ACP  A 999 (-2.9A)
None
MG  A 401 ( 2.8A)
 0.74A 5yf9B-2punA:
9.1		 5yf9B-2punA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA606_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 2pun METHYLTHIORIBOSE
KINASE
(Bacillus
subtilis) 		4 / 5 GLU A 337
ASP A 233
HIS A 235
THR A 177
 None
SR1  A 998 (-2.7A)
SR1  A 998 ( 4.7A)
None
 1.44A 6b58A-2punA:
undetectable		 6b58A-2punA:
21.85