SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2put'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1502_0
(FERROCHELATASE)		 2put ISOMERASE DOMAIN OF
GLUTAMINE-FRUCTOSE-6
-PHOSPHATE
TRANSAMINASE
(ISOMERIZING)
(Candida
albicans) 		4 / 8 ARG A 372
LEU A 382
VAL A 473
GLY A 474
 UD1  A5002 (-3.9A)
None
None
UD1  A5002 (-3.2A)
 1.05A 1hrkA-2putA:
1.8		 1hrkA-2putA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I6V_C_RFPC1640_1
(DNA-DIRECTED RNA
POLYMERASE)		 2put ISOMERASE DOMAIN OF
GLUTAMINE-FRUCTOSE-6
-PHOSPHATE
TRANSAMINASE
(ISOMERIZING)
(Candida
albicans) 		5 / 12 GLN A 463
LEU A 466
ARG A 397
GLU A 428
ILE A 401
 None
 1.46A 1i6vC-2putA:
0.0		 1i6vC-2putA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JB0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 2put ISOMERASE DOMAIN OF
GLUTAMINE-FRUCTOSE-6
-PHOSPHATE
TRANSAMINASE
(ISOMERIZING)
(Candida
albicans) 		5 / 9 PHE A 622
SER A 627
GLY A 576
ALA A 580
GLY A 574
 None
 1.24A 1jb0A-2putA:
undetectable		 1jb0A-2putA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB504_1
(YKOF)		 2put ISOMERASE DOMAIN OF
GLUTAMINE-FRUCTOSE-6
-PHOSPHATE
TRANSAMINASE
(ISOMERIZING)
(Candida
albicans) 		4 / 6 PRO A 669
PHE A 375
LEU A 539
ILE A 542
 None
 1.07A 1sbrA-2putA:
undetectable
1sbrB-2putA:
undetectable		 1sbrA-2putA:
19.68
1sbrB-2putA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		 2put ISOMERASE DOMAIN OF
GLUTAMINE-FRUCTOSE-6
-PHOSPHATE
TRANSAMINASE
(ISOMERIZING)
(Candida
albicans) 		5 / 12 VAL A 473
LEU A 389
SER A 390
LEU A 385
LEU A 471
 None
 1.22A 1ya4B-2putA:
undetectable		 1ya4B-2putA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_1
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 2put ISOMERASE DOMAIN OF
GLUTAMINE-FRUCTOSE-6
-PHOSPHATE
TRANSAMINASE
(ISOMERIZING)
(Candida
albicans) 		3 / 3 SER A 688
THR A 508
GLN A 361
 None
 0.80A 2fk8A-2putA:
undetectable		 2fk8A-2putA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_A_SALA257_1
(TRANSCRIPTIONAL
REGULATOR)		 2put ISOMERASE DOMAIN OF
GLUTAMINE-FRUCTOSE-6
-PHOSPHATE
TRANSAMINASE
(ISOMERIZING)
(Candida
albicans) 		4 / 8 ALA A 430
PHE A 448
THR A 455
ILE A 459
 None
None
F6R  A5003 (-3.2A)
None
 0.96A 3bpxA-2putA:
undetectable
3bpxB-2putA:
undetectable		 3bpxA-2putA:
17.93
3bpxB-2putA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_2
(PROTEASE)		 2put ISOMERASE DOMAIN OF
GLUTAMINE-FRUCTOSE-6
-PHOSPHATE
TRANSAMINASE
(ISOMERIZING)
(Candida
albicans) 		5 / 9 ALA A 623
GLY A 574
LEU A 572
VAL A 639
ILE A 636
 None
 1.16A 3em4B-2putA:
undetectable		 3em4B-2putA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_0
(REPRESSOR PROTEIN
MPHR(A))		 2put ISOMERASE DOMAIN OF
GLUTAMINE-FRUCTOSE-6
-PHOSPHATE
TRANSAMINASE
(ISOMERIZING)
(Candida
albicans) 		5 / 12 THR A 421
VAL A 447
VAL A 449
ILE A 493
THR A 368
 None
 1.38A 3frqA-2putA:
undetectable		 3frqA-2putA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 2put ISOMERASE DOMAIN OF
GLUTAMINE-FRUCTOSE-6
-PHOSPHATE
TRANSAMINASE
(ISOMERIZING)
(Candida
albicans) 		5 / 9 ALA A 412
LEU A 678
ILE A 535
LEU A 519
ILE A 416
 None
 1.22A 3jw3B-2putA:
undetectable		 3jw3B-2putA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PCQ_A_PQNA847_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 2put ISOMERASE DOMAIN OF
GLUTAMINE-FRUCTOSE-6
-PHOSPHATE
TRANSAMINASE
(ISOMERIZING)
(Candida
albicans) 		5 / 9 PHE A 622
SER A 627
GLY A 576
ALA A 580
GLY A 574
 None
 1.24A 3pcqA-2putA:
undetectable		 3pcqA-2putA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_B_IMNB701_1
(CYCLOOXYGENASE-2)		 2put ISOMERASE DOMAIN OF
GLUTAMINE-FRUCTOSE-6
-PHOSPHATE
TRANSAMINASE
(ISOMERIZING)
(Candida
albicans) 		5 / 12 SER A 627
VAL A 632
GLY A 603
ALA A 602
LEU A 601
 None
 1.17A 4coxB-2putA:
undetectable		 4coxB-2putA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_C_SAMC800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2put ISOMERASE DOMAIN OF
GLUTAMINE-FRUCTOSE-6
-PHOSPHATE
TRANSAMINASE
(ISOMERIZING)
(Candida
albicans) 		5 / 11 ILE A 493
ALA A 495
GLY A 496
GLY A 500
ASN A 477
 None
 0.95A 4e47C-2putA:
undetectable		 4e47C-2putA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_C_SAMC401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2put ISOMERASE DOMAIN OF
GLUTAMINE-FRUCTOSE-6
-PHOSPHATE
TRANSAMINASE
(ISOMERIZING)
(Candida
albicans) 		5 / 11 ILE A 493
ALA A 495
GLY A 496
GLY A 500
ASN A 477
 None
 0.94A 4jdsC-2putA:
undetectable		 4jdsC-2putA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2put ISOMERASE DOMAIN OF
GLUTAMINE-FRUCTOSE-6
-PHOSPHATE
TRANSAMINASE
(ISOMERIZING)
(Candida
albicans) 		5 / 12 ILE A 493
ALA A 495
GLY A 496
GLY A 500
ASN A 477
 None
 0.87A 4jlgA-2putA:
undetectable		 4jlgA-2putA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_1_PQN12001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 2put ISOMERASE DOMAIN OF
GLUTAMINE-FRUCTOSE-6
-PHOSPHATE
TRANSAMINASE
(ISOMERIZING)
(Candida
albicans) 		6 / 11 PHE A 622
SER A 627
GLY A 576
ALA A 580
GLY A 574
ALA A 692
 None
 1.30A 4l6v1-2putA:
undetectable
4l6v6-2putA:
undetectable		 4l6v1-2putA:
18.55
4l6v6-2putA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 2put ISOMERASE DOMAIN OF
GLUTAMINE-FRUCTOSE-6
-PHOSPHATE
TRANSAMINASE
(ISOMERIZING)
(Candida
albicans) 		5 / 9 PHE A 622
SER A 627
ALA A 580
GLY A 574
ALA A 692
 None
 1.26A 4l6va-2putA:
undetectable
4l6vf-2putA:
0.0		 4l6va-2putA:
18.55
4l6vf-2putA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2put ISOMERASE DOMAIN OF
GLUTAMINE-FRUCTOSE-6
-PHOSPHATE
TRANSAMINASE
(ISOMERIZING)
(Candida
albicans) 		4 / 8 GLU A 670
GLN A 545
ILE A 546
LEU A 678
 None
 0.91A 4mj8A-2putA:
undetectable		 4mj8A-2putA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2put ISOMERASE DOMAIN OF
GLUTAMINE-FRUCTOSE-6
-PHOSPHATE
TRANSAMINASE
(ISOMERIZING)
(Candida
albicans) 		5 / 12 LEU A 514
PHE A 517
THR A 445
ILE A 398
ILE A 392
 None
 1.07A 4x5jA-2putA:
undetectable		 4x5jA-2putA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_2
(THYROXINE-BINDING
GLOBULIN)		 2put ISOMERASE DOMAIN OF
GLUTAMINE-FRUCTOSE-6
-PHOSPHATE
TRANSAMINASE
(ISOMERIZING)
(Candida
albicans) 		3 / 3 LEU A 434
ARG A 437
ARG A 468
 None
 0.63A 4yiaB-2putA:
undetectable		 4yiaB-2putA:
7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2put ISOMERASE DOMAIN OF
GLUTAMINE-FRUCTOSE-6
-PHOSPHATE
TRANSAMINASE
(ISOMERIZING)
(Candida
albicans) 		5 / 11 ILE A 493
ALA A 495
GLY A 496
GLY A 500
ASN A 477
 None
 0.91A 5ayfA-2putA:
undetectable		 5ayfA-2putA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2put ISOMERASE DOMAIN OF
GLUTAMINE-FRUCTOSE-6
-PHOSPHATE
TRANSAMINASE
(ISOMERIZING)
(Candida
albicans) 		4 / 8 SER A 569
HIS A 596
LEU A 571
LEU A 572
 None
 0.88A 5dzkd-2putA:
undetectable
5dzkr-2putA:
undetectable		 5dzkd-2putA:
20.33
5dzkr-2putA:
0.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_S_BEZS801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2put ISOMERASE DOMAIN OF
GLUTAMINE-FRUCTOSE-6
-PHOSPHATE
TRANSAMINASE
(ISOMERIZING)
(Candida
albicans) 		4 / 6 SER A 569
HIS A 596
LEU A 571
LEU A 572
 None
 0.98A 5dzke-2putA:
undetectable
5dzks-2putA:
undetectable		 5dzke-2putA:
20.33
5dzks-2putA:
0.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2put ISOMERASE DOMAIN OF
GLUTAMINE-FRUCTOSE-6
-PHOSPHATE
TRANSAMINASE
(ISOMERIZING)
(Candida
albicans) 		5 / 12 LEU A 514
PHE A 517
THR A 445
ILE A 398
ILE A 392
 None
 1.12A 5e8qA-2putA:
undetectable		 5e8qA-2putA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8R_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 2put ISOMERASE DOMAIN OF
GLUTAMINE-FRUCTOSE-6
-PHOSPHATE
TRANSAMINASE
(ISOMERIZING)
(Candida
albicans) 		5 / 9 PHE A 622
SER A 627
GLY A 576
ALA A 580
GLY A 574
 None
 1.19A 5l8rA-2putA:
undetectable		 5l8rA-2putA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_B_OAQB302_0
(SULFOTRANSFERASE)		 2put ISOMERASE DOMAIN OF
GLUTAMINE-FRUCTOSE-6
-PHOSPHATE
TRANSAMINASE
(ISOMERIZING)
(Candida
albicans) 		5 / 12 ILE A 636
LEU A 571
ILE A 649
LEU A 628
THR A 624
 None
 1.22A 5tiwB-2putA:
undetectable		 5tiwB-2putA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_0
(REGULATORY PROTEIN
TETR)		 2put ISOMERASE DOMAIN OF
GLUTAMINE-FRUCTOSE-6
-PHOSPHATE
TRANSAMINASE
(ISOMERIZING)
(Candida
albicans) 		5 / 12 MET A 369
ALA A 513
SER A 509
ILE A 542
CYH A 674
 None
 1.01A 5vlmB-2putA:
undetectable		 5vlmB-2putA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 2put ISOMERASE DOMAIN OF
GLUTAMINE-FRUCTOSE-6
-PHOSPHATE
TRANSAMINASE
(ISOMERIZING)
(Candida
albicans) 		5 / 9 ILE A 493
ALA A 495
GLY A 496
GLY A 500
ASN A 477
 None
 0.86A 6nm4B-2putA:
undetectable		 6nm4B-2putA:
18.26