SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pvc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P9G_A_ACTA42_0
(EAFP 2)		 2pvc DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3-LIKE
(Homo
sapiens) 		3 / 3 CYH B  55
ARG B  35
CYH B  99
 None
ZN  B 605 ( 4.6A)
ZN  B 605 (-2.1A)
 1.19A 1p9gA-2pvcB:
undetectable		 1p9gA-2pvcB:
7.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P9G_A_ACTA42_0
(EAFP 2)		 2pvc DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3-LIKE
(Homo
sapiens) 		3 / 3 CYH B 121
ARG B  35
CYH B  99
 ZN  B 605 (-2.1A)
ZN  B 605 ( 4.6A)
ZN  B 605 (-2.1A)
 1.31A 1p9gA-2pvcB:
undetectable		 1p9gA-2pvcB:
7.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P9G_A_ACTA42_0
(EAFP 2)		 2pvc DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3-LIKE
(Homo
sapiens) 		3 / 3 CYH B 121
ARG B  35
CYH B 118
 ZN  B 605 (-2.1A)
ZN  B 605 ( 4.6A)
ZN  B 605 (-2.2A)
 1.31A 1p9gA-2pvcB:
undetectable		 1p9gA-2pvcB:
7.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_D_BEZD2385_0
(CES1 PROTEIN)		 2pvc DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3-LIKE
(Homo
sapiens) 		4 / 5 LEU B 346
LEU B 248
LEU B 355
LEU B 288
 None
 0.70A 1yajD-2pvcB:
undetectable		 1yajD-2pvcB:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4K_A_DR7A301_1
(PROTEASE)		 2pvc DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3-LIKE
(Homo
sapiens) 		5 / 12 ILE B  72
GLY B  71
GLY B  70
ILE B  49
ILE B  98
 None
 1.03A 2o4kA-2pvcB:
undetectable		 2o4kA-2pvcB:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		 2pvc DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3-LIKE
(Homo
sapiens) 		5 / 12 LEU B 206
LEU B 203
MET B 283
LEU B 371
CYH B 367
 None
 1.38A 2w8yB-2pvcB:
undetectable		 2w8yB-2pvcB:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XNR_A_ACTA1001_0
(NUCLEAR
POLYADENYLATED
RNA-BINDING PROTEIN
3)		 2pvc DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3-LIKE
(Homo
sapiens) 		3 / 3 SER B 149
ARG B 150
GLN B 155
 None
 0.66A 2xnrA-2pvcB:
undetectable		 2xnrA-2pvcB:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5T_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 2pvc DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3-LIKE
(Homo
sapiens) 		4 / 7 SER B 299
VAL B 297
TRP B 324
PHE B 284
 None
 1.42A 3n5tA-2pvcB:
undetectable
3n5tB-2pvcB:
undetectable		 3n5tA-2pvcB:
23.68
3n5tB-2pvcB:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA502_1
(CYTOCHROME P450 2B6)		 2pvc DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3-LIKE
(Homo
sapiens) 		5 / 11 LEU B  81
ARG B 115
LEU B  67
GLU B 373
PHE B  85
 None
 1.31A 3ua5A-2pvcB:
undetectable		 3ua5A-2pvcB:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5J_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2pvc DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3-LIKE
(Homo
sapiens) 		4 / 7 TRP B 324
PHE B 284
SER B 299
VAL B 297
 None
 1.41A 4k5jA-2pvcB:
undetectable
4k5jB-2pvcB:
undetectable		 4k5jA-2pvcB:
23.73
4k5jB-2pvcB:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M48_A_21BA704_1
(TRANSPORTER)		 2pvc DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3-LIKE
(Homo
sapiens) 		4 / 8 PHE B 196
VAL B 241
GLY B 243
ALA B 270
 None
 0.91A 4m48A-2pvcB:
undetectable		 4m48A-2pvcB:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_ACTA202_0
(RETINOL-BINDING
PROTEIN 2)		 2pvc DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3-LIKE
(Homo
sapiens) 		4 / 6 TYR B 117
GLU B 373
LEU B 144
GLN B  93
 None
 1.47A 4qztA-2pvcB:
undetectable		 4qztA-2pvcB:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_D_READ602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 2pvc DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3-LIKE
(Homo
sapiens) 		5 / 12 ILE B  72
GLY B  70
CYH B 100
CYH B  96
LEU B  67
 None
None
None
ZN  B 605 (-2.2A)
None
 1.12A 5fhzD-2pvcB:
undetectable		 5fhzD-2pvcB:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_C_IPHC101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 2pvc DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3-LIKE
(Homo
sapiens) 		4 / 5 CYH B  56
ILE B  54
CYH B  53
HIS B  65
 ZN  B 604 (-2.2A)
None
ZN  B 604 (-2.1A)
None
 1.47A 5hrqC-2pvcB:
undetectable
5hrqD-2pvcB:
undetectable
5hrqL-2pvcB:
undetectable		 5hrqC-2pvcB:
7.12
5hrqD-2pvcB:
7.47
5hrqL-2pvcB:
7.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		 2pvc DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3-LIKE
(Homo
sapiens) 		4 / 8 HIS B 264
GLN B 268
LEU B 260
LEU B 302
 None
 1.14A 5hs6A-2pvcB:
5.7		 5hs6A-2pvcB:
19.90