SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pvp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_F_BEZF5023_0
(CES1 PROTEIN)		 2pvp D-ALANINE-D-ALANINE
LIGASE
(Helicobacter
pylori) 		5 / 6 GLY A   8
SER A  17
LEU A 105
ILE A 304
HIS A  96
 None
 1.21A 1yajF-2pvpA:
undetectable		 1yajF-2pvpA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_J_BEZJ5041_0
(CES1 PROTEIN)		 2pvp D-ALANINE-D-ALANINE
LIGASE
(Helicobacter
pylori) 		4 / 4 GLY A   8
SER A  17
ILE A 304
HIS A  96
 None
 1.04A 1yajJ-2pvpA:
undetectable		 1yajJ-2pvpA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2pvp D-ALANINE-D-ALANINE
LIGASE
(Helicobacter
pylori) 		4 / 8 ASN A 310
PHE A 316
VAL A  27
PHE A   3
 None
 1.26A 2wekA-2pvpA:
undetectable		 2wekA-2pvpA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2pvp D-ALANINE-D-ALANINE
LIGASE
(Helicobacter
pylori) 		4 / 6 LEU A  24
ILE A  16
ALA A 309
LEU A 312
 None
 0.81A 3kk6B-2pvpA:
undetectable		 3kk6B-2pvpA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR5_A_SRYA1860_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S12)		 2pvp D-ALANINE-D-ALANINE
LIGASE
(Helicobacter
pylori) 		3 / 3 LYS A 171
PRO A 172
LYS A 130
 None
 1.44A 4dr5L-2pvpA:
undetectable		 4dr5L-2pvpA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR6_A_SRYA1956_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S12)		 2pvp D-ALANINE-D-ALANINE
LIGASE
(Helicobacter
pylori) 		3 / 3 LYS A 171
PRO A 172
LYS A 130
 None
 1.47A 4dr6L-2pvpA:
undetectable		 4dr6L-2pvpA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUZ_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		 2pvp D-ALANINE-D-ALANINE
LIGASE
(Helicobacter
pylori) 		3 / 3 LYS A 171
PRO A 172
LYS A 130
 None
 1.44A 4duzL-2pvpA:
undetectable		 4duzL-2pvpA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV7_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		 2pvp D-ALANINE-D-ALANINE
LIGASE
(Helicobacter
pylori) 		3 / 3 LYS A 171
PRO A 172
LYS A 130
 None
 1.41A 4dv7L-2pvpA:
undetectable		 4dv7L-2pvpA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_B_ASWB1301_1
(DNA TOPOISOMERASE
2-BETA)		 2pvp D-ALANINE-D-ALANINE
LIGASE
(Helicobacter
pylori) 		4 / 7 ILE A 285
PRO A 303
GLY A 100
ALA A 123
 None
 0.92A 4g0uB-2pvpA:
2.4		 4g0uB-2pvpA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_A_SAMA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 2pvp D-ALANINE-D-ALANINE
LIGASE
(Helicobacter
pylori) 		5 / 12 ILE A 304
GLY A 103
GLY A 100
ARG A 120
SER A 124
 None
 0.84A 4iv0A-2pvpA:
undetectable		 4iv0A-2pvpA:
28.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 2pvp D-ALANINE-D-ALANINE
LIGASE
(Helicobacter
pylori) 		5 / 12 ILE A 304
GLY A 103
GLY A 100
ARG A 120
SER A 124
 None
 0.85A 4iv0B-2pvpA:
undetectable		 4iv0B-2pvpA:
28.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 2pvp D-ALANINE-D-ALANINE
LIGASE
(Helicobacter
pylori) 		5 / 12 ILE A 304
GLY A 103
GLY A 100
ARG A 120
SER A 124
 None
 0.85A 4mwzA-2pvpA:
undetectable		 4mwzA-2pvpA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 2pvp D-ALANINE-D-ALANINE
LIGASE
(Helicobacter
pylori) 		5 / 12 ILE A 304
GLY A 103
GLY A 100
ARG A 120
SER A 124
 None
 0.85A 4mwzB-2pvpA:
undetectable		 4mwzB-2pvpA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAE_A_NIZA804_1
(CATALASE-PEROXIDASE)		 2pvp D-ALANINE-D-ALANINE
LIGASE
(Helicobacter
pylori) 		4 / 6 PHE A  44
ASP A  99
LEU A 108
HIS A  42
 None
 1.38A 4paeA-2pvpA:
undetectable		 4paeA-2pvpA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		 2pvp D-ALANINE-D-ALANINE
LIGASE
(Helicobacter
pylori) 		5 / 6 SER A 173
GLU A 203
GLY A 100
ASP A  99
GLY A 103
 None
 1.21A 5cdpA-2pvpA:
undetectable
5cdpB-2pvpA:
2.0		 5cdpA-2pvpA:
22.91
5cdpB-2pvpA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_A_IPHA101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 2pvp D-ALANINE-D-ALANINE
LIGASE
(Helicobacter
pylori) 		4 / 4 CYH A 287
LEU A 275
LEU A 298
ALA A 137
 None
 1.10A 5hpuA-2pvpA:
undetectable
5hpuB-2pvpA:
undetectable		 5hpuA-2pvpA:
4.89
5hpuB-2pvpA:
6.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_1
(METHYLTRANSFERASE)		 2pvp D-ALANINE-D-ALANINE
LIGASE
(Helicobacter
pylori) 		4 / 7 LEU A 279
PHE A 280
ILE A 117
ASP A 281
 None
 0.96A 5n5dA-2pvpA:
undetectable		 5n5dA-2pvpA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_B_ACTB804_0
(UNCHARACTERIZED
PROTEIN)		 2pvp D-ALANINE-D-ALANINE
LIGASE
(Helicobacter
pylori) 		4 / 4 HIS A  42
VAL A  95
LEU A  38
ALA A  10
 None
 1.31A 6d8pB-2pvpA:
3.1		 6d8pB-2pvpA:
20.58