SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pvs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_D_DMED999_1
(ACETYLCHOLINESTERASE)		 2pvs PANCREATIC
LIPASE-RELATED
PROTEIN 2
(Homo
sapiens) 		4 / 8 TRP A  85
GLY A  76
SER A 152
HIS A 263
 None
 1.07A 1maaD-2pvsA:
9.0		 1maaD-2pvsA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX8_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO)		 2pvs PANCREATIC
LIPASE-RELATED
PROTEIN 2
(Homo
sapiens) 		5 / 12 LEU A 447
ALA A 417
LEU A 346
THR A 384
PHE A 297
 None
 1.18A 1mx8A-2pvsA:
undetectable		 1mx8A-2pvsA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX8_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO)		 2pvs PANCREATIC
LIPASE-RELATED
PROTEIN 2
(Homo
sapiens) 		5 / 12 LEU A 447
LEU A 346
THR A 384
PHE A 297
ILE A 358
 None
 1.28A 1mx8A-2pvsA:
undetectable		 1mx8A-2pvsA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)		 2pvs PANCREATIC
LIPASE-RELATED
PROTEIN 2
(Homo
sapiens) 		5 / 10 TRP A  85
GLY A 154
GLY A  76
SER A 152
HIS A 263
 None
 1.19A 1w76B-2pvsA:
9.8		 1w76B-2pvsA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_A_SAMA3142_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 2pvs PANCREATIC
LIPASE-RELATED
PROTEIN 2
(Homo
sapiens) 		4 / 4 HIS A  75
ASP A  83
ASN A  47
ASP A 105
 None
None
SO4  A 454 (-3.4A)
None
 1.42A 1wg8A-2pvsA:
2.4		 1wg8A-2pvsA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOS_A_VIAA1_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 2pvs PANCREATIC
LIPASE-RELATED
PROTEIN 2
(Homo
sapiens) 		5 / 12 LEU A 346
SER A 367
GLN A 445
PHE A 401
ILE A 356
 None
 1.50A 1xosA-2pvsA:
undetectable		 1xosA-2pvsA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_B_GBNB914_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 2pvs PANCREATIC
LIPASE-RELATED
PROTEIN 2
(Homo
sapiens) 		5 / 10 GLU A 160
GLY A 125
THR A 128
ALA A 129
ALA A 126
 None
 1.10A 2ej3B-2pvsA:
undetectable		 2ej3B-2pvsA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_C_GBNC1414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 2pvs PANCREATIC
LIPASE-RELATED
PROTEIN 2
(Homo
sapiens) 		5 / 8 GLU A 160
GLY A 125
THR A 128
ALA A 129
ALA A 126
 None
 1.12A 2ej3C-2pvsA:
undetectable		 2ej3C-2pvsA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_1
(HYPOTHETICAL PROTEIN
LMO1582)		 2pvs PANCREATIC
LIPASE-RELATED
PROTEIN 2
(Homo
sapiens) 		4 / 4 THR A 128
THR A  35
ASP A 105
ASP A  83
 None
 1.44A 2f8lA-2pvsA:
2.6		 2f8lA-2pvsA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 2pvs PANCREATIC
LIPASE-RELATED
PROTEIN 2
(Homo
sapiens) 		3 / 3 ALA A 155
GLY A 216
SER A 266
 None
 0.53A 2ivuA-2pvsA:
undetectable		 2ivuA-2pvsA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBN_A_CAMA442_0
(CYTOCHROME P450-CAM)		 2pvs PANCREATIC
LIPASE-RELATED
PROTEIN 2
(Homo
sapiens) 		4 / 7 PHE A 297
VAL A 389
VAL A 422
VAL A 342
 None
 0.94A 2qbnA-2pvsA:
undetectable		 2qbnA-2pvsA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA502_0
(CHORISMATE SYNTHASE)		 2pvs PANCREATIC
LIPASE-RELATED
PROTEIN 2
(Homo
sapiens) 		3 / 3 GLY A  76
ASP A  79
SER A 110
 None
 0.68A 2qhfA-2pvsA:
undetectable		 2qhfA-2pvsA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9X_A_NIMA1_1
(LACTOTRANSFERRIN')		 2pvs PANCREATIC
LIPASE-RELATED
PROTEIN 2
(Homo
sapiens) 		4 / 4 GLU A 426
GLY A 428
THR A 429
GLU A 430
 None
 0.93A 3e9xA-2pvsA:
0.7		 3e9xA-2pvsA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1475_0
(MJ0495-LIKE PROTEIN)		 2pvs PANCREATIC
LIPASE-RELATED
PROTEIN 2
(Homo
sapiens) 		5 / 8 ILE A 372
ILE A 356
SER A 436
GLN A 445
GLY A 416
 None
 1.50A 4ac9C-2pvsA:
2.1		 4ac9C-2pvsA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		 2pvs PANCREATIC
LIPASE-RELATED
PROTEIN 2
(Homo
sapiens) 		5 / 12 ASP A 225
HIS A 156
ASP A 176
HIS A 203
GLY A 216
 None
 1.42A 4bz6A-2pvsA:
undetectable
4bz6B-2pvsA:
undetectable		 4bz6A-2pvsA:
22.87
4bz6B-2pvsA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_A_HFGA1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 2pvs PANCREATIC
LIPASE-RELATED
PROTEIN 2
(Homo
sapiens) 		5 / 12 GLU A 160
VAL A 123
PRO A  27
THR A  18
GLY A  17
 None
 1.30A 4hvcA-2pvsA:
undetectable		 4hvcA-2pvsA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_A_SAMA401_0
(METHYLTRANSFERASE
MPPJ)		 2pvs PANCREATIC
LIPASE-RELATED
PROTEIN 2
(Homo
sapiens) 		5 / 12 GLY A 150
GLY A 154
ILE A 172
ALA A 159
PHE A 267
 None
None
None
CA  A 502 ( 4.7A)
None
 1.11A 4kicA-2pvsA:
undetectable		 4kicA-2pvsA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_0
(METHYLTRANSFERASE
MPPJ)		 2pvs PANCREATIC
LIPASE-RELATED
PROTEIN 2
(Homo
sapiens) 		5 / 12 GLY A 150
GLY A 154
ILE A 172
ALA A 159
PHE A 267
 None
None
None
CA  A 502 ( 4.7A)
None
 1.10A 4kicB-2pvsA:
undetectable		 4kicB-2pvsA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_D_FOLD301_1
(FOLATE RECEPTOR
ALPHA)		 2pvs PANCREATIC
LIPASE-RELATED
PROTEIN 2
(Homo
sapiens) 		3 / 3 HIS A 151
TRP A 106
SER A 266
 None
 1.14A 4lrhD-2pvsA:
undetectable		 4lrhD-2pvsA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLF_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 2pvs PANCREATIC
LIPASE-RELATED
PROTEIN 2
(Homo
sapiens) 		5 / 12 GLU A 160
VAL A 123
PRO A  27
THR A  18
GLY A  17
 None
 1.29A 4olfA-2pvsA:
undetectable		 4olfA-2pvsA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 2pvs PANCREATIC
LIPASE-RELATED
PROTEIN 2
(Homo
sapiens) 		3 / 3 SER A 152
ASP A  34
ASP A  79
 None
 0.80A 4uckA-2pvsA:
undetectable		 4uckA-2pvsA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_V_MFXV2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2pvs PANCREATIC
LIPASE-RELATED
PROTEIN 2
(Homo
sapiens) 		5 / 5 SER A 136
ARG A 164
GLY A 162
GLU A 160
ARG A 168
 None
 1.44A 5cdqR-2pvsA:
undetectable
5cdqS-2pvsA:
3.1
5cdqT-2pvsA:
undetectable		 5cdqR-2pvsA:
21.04
5cdqS-2pvsA:
17.63
5cdqT-2pvsA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 2pvs PANCREATIC
LIPASE-RELATED
PROTEIN 2
(Homo
sapiens) 		5 / 12 ALA A  81
SER A  84
THR A 128
ARG A 111
GLY A 109
 None
None
None
SO4  A 451 ( 3.0A)
None
 1.28A 5m54E-2pvsA:
3.9		 5m54E-2pvsA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 2pvs PANCREATIC
LIPASE-RELATED
PROTEIN 2
(Homo
sapiens) 		5 / 12 ALA A  81
SER A  84
THR A 128
ARG A 111
GLY A 109
 None
None
None
SO4  A 451 ( 3.0A)
None
 1.20A 5m5cB-2pvsA:
2.5		 5m5cB-2pvsA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2pvs PANCREATIC
LIPASE-RELATED
PROTEIN 2
(Homo
sapiens) 		5 / 12 ILE A 132
ALA A 161
ILE A 102
PHE A  72
ALA A 158
 None
 1.21A 6a5zD-2pvsA:
undetectable		 6a5zD-2pvsA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_HFGA603_0
(UNCHARACTERIZED
PROTEIN)		 2pvs PANCREATIC
LIPASE-RELATED
PROTEIN 2
(Homo
sapiens) 		5 / 12 GLU A 160
VAL A 123
PRO A  27
THR A  18
GLY A  17
 None
 1.33A 6mn8A-2pvsA:
undetectable		 6mn8A-2pvsA:
20.87