SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pvu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_C_EAAC223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 2pvu ARTJ
(Geobacillus
stearothermophil
us) 		4 / 8 TYR A 103
PHE A 104
GLY A  86
PHE A  45
 None
SO4  A 253 ( 4.2A)
LYS  A 301 (-4.9A)
None
 0.94A 1gsfC-2pvuA:
undetectable		 1gsfC-2pvuA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2pvu ARTJ
(Geobacillus
stearothermophil
us) 		4 / 8 ILE A  84
PHE A 240
GLY A  44
ILE A  42
 None
 0.96A 2qwxA-2pvuA:
undetectable
2qwxB-2pvuA:
undetectable		 2qwxA-2pvuA:
22.18
2qwxB-2pvuA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_B_MK1B902_1
(PROTEASE)		 2pvu ARTJ
(Geobacillus
stearothermophil
us) 		5 / 12 ASP A  46
ILE A  84
GLY A  83
GLY A  26
ILE A  66
 None
 1.06A 2r5pA-2pvuA:
undetectable		 2r5pA-2pvuA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_D_MK1D902_1
(PROTEASE)		 2pvu ARTJ
(Geobacillus
stearothermophil
us) 		5 / 12 ASP A  46
ILE A  84
GLY A  83
GLY A  26
ILE A  66
 None
 1.06A 2r5pC-2pvuA:
undetectable		 2r5pC-2pvuA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 2pvu ARTJ
(Geobacillus
stearothermophil
us) 		5 / 12 MET A  54
ALA A 222
VAL A 219
PHE A 209
LEU A  75
 None
 1.16A 3b0wB-2pvuA:
undetectable		 3b0wB-2pvuA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE202_1
(PROTEIN S100-A4)		 2pvu ARTJ
(Geobacillus
stearothermophil
us) 		5 / 11 LEU A  71
SER A  74
PHE A  72
ILE A 208
ASP A  81
 None
 1.24A 3ko0C-2pvuA:
undetectable
3ko0D-2pvuA:
undetectable
3ko0E-2pvuA:
undetectable
3ko0F-2pvuA:
undetectable		 3ko0C-2pvuA:
16.61
3ko0D-2pvuA:
16.61
3ko0E-2pvuA:
16.61
3ko0F-2pvuA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_H_TFPH202_1
(PROTEIN S100-A4)		 2pvu ARTJ
(Geobacillus
stearothermophil
us) 		5 / 12 ASP A  81
LEU A  71
SER A  74
PHE A  72
ILE A 208
 None
 1.31A 3ko0G-2pvuA:
0.0
3ko0H-2pvuA:
undetectable
3ko0I-2pvuA:
undetectable
3ko0J-2pvuA:
undetectable		 3ko0G-2pvuA:
16.61
3ko0H-2pvuA:
16.61
3ko0I-2pvuA:
16.61
3ko0J-2pvuA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 2pvu ARTJ
(Geobacillus
stearothermophil
us) 		4 / 7 ALA A 121
PHE A 200
ALA A 140
LEU A 144
 None
 0.94A 4du2A-2pvuA:
undetectable		 4du2A-2pvuA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_A_P2EA1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 2pvu ARTJ
(Geobacillus
stearothermophil
us) 		4 / 4 PRO A 210
MET A  54
GLY A  58
VAL A  23
 None
 1.48A 6ak3A-2pvuA:
undetectable		 6ak3A-2pvuA:
16.61