SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pvz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AO8_A_MTXA170_2
(DIHYDROFOLATE
REDUCTASE)		 2pvz PRPF METHYLACONITATE
ISOMERASE
(Shewanella
oneidensis) 		4 / 4 TRP A 140
LEU A  77
ARG A 382
THR A 323
 None
None
None
EDO  A1005 (-3.1A)
 1.31A 1ao8A-2pvzA:
0.0		 1ao8A-2pvzA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_1
(PROTEIN (ADENOSINE
KINASE))		 2pvz PRPF METHYLACONITATE
ISOMERASE
(Shewanella
oneidensis) 		5 / 12 GLN A  93
GLY A 322
GLY A 108
ASN A 109
PHE A  91
 CA  A1003 ( 4.7A)
EDO  A1005 (-3.6A)
EDO  A1005 (-3.8A)
EDO  A1005 (-4.0A)
None
 0.89A 1bx4A-2pvzA:
undetectable		 1bx4A-2pvzA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_1
(TRANSTHYRETIN)		 2pvz PRPF METHYLACONITATE
ISOMERASE
(Shewanella
oneidensis) 		4 / 6 LYS A  59
ALA A  67
SER A  69
THR A  71
 CA  A1002 (-3.3A)
None
CA  A1003 (-3.3A)
None
 1.04A 1ictB-2pvzA:
undetectable		 1ictB-2pvzA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_1
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 2pvz PRPF METHYLACONITATE
ISOMERASE
(Shewanella
oneidensis) 		4 / 7 LEU A 338
ILE A 222
THR A 224
MET A 320
 None
 1.25A 1kglA-2pvzA:
0.1		 1kglA-2pvzA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2pvz PRPF METHYLACONITATE
ISOMERASE
(Shewanella
oneidensis) 		3 / 3 VAL A 326
ALA A 325
HIS A 355
 None
 0.78A 1q23L-2pvzA:
undetectable		 1q23L-2pvzA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_A_ADNA1_1
(YTAA PROTEIN)		 2pvz PRPF METHYLACONITATE
ISOMERASE
(Shewanella
oneidensis) 		4 / 7 ILE A 267
ILE A 256
LEU A 205
ILE A 225
 None
 0.77A 2q83A-2pvzA:
undetectable		 2q83A-2pvzA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_1
(WNT INHIBITORY
FACTOR 1)		 2pvz PRPF METHYLACONITATE
ISOMERASE
(Shewanella
oneidensis) 		4 / 5 ILE A 144
PHE A 181
PRO A 223
VAL A 170
 EDO  A1010 ( 3.7A)
None
EDO  A1010 ( 4.5A)
None
 0.99A 2ygnA-2pvzA:
undetectable		 2ygnA-2pvzA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA601_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 2pvz PRPF METHYLACONITATE
ISOMERASE
(Shewanella
oneidensis) 		4 / 7 GLY A  24
ALA A  14
VAL A 392
ILE A  51
 None
EDO  A1007 (-4.8A)
None
None
 0.77A 3a2qA-2pvzA:
undetectable		 3a2qA-2pvzA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BC9_A_ACRA901_1
(ALPHA AMYLASE,
CATALYTIC REGION)		 2pvz PRPF METHYLACONITATE
ISOMERASE
(Shewanella
oneidensis) 		4 / 7 ASP A  97
SER A  95
SER A 275
ASP A 271
 None
 1.23A 3bc9A-2pvzA:
undetectable		 3bc9A-2pvzA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_A_BEZA264_0
(ECHA1_1)		 2pvz PRPF METHYLACONITATE
ISOMERASE
(Shewanella
oneidensis) 		4 / 8 ALA A 220
ILE A 218
ALA A 364
ALA A 378
 None
 0.74A 3r9tA-2pvzA:
undetectable		 3r9tA-2pvzA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_B_SVRB516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 2pvz PRPF METHYLACONITATE
ISOMERASE
(Shewanella
oneidensis) 		4 / 7 PRO A 184
GLY A 221
ALA A 220
ALA A 331
 None
EDO  A1010 (-3.6A)
None
None
 0.80A 3ur0B-2pvzA:
undetectable		 3ur0B-2pvzA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_0
(METHYLTRANSFERASE
WBDD)		 2pvz PRPF METHYLACONITATE
ISOMERASE
(Shewanella
oneidensis) 		5 / 12 GLY A 115
ALA A 113
ILE A 119
VAL A 152
ILE A 154
 None
 1.12A 4aztA-2pvzA:
undetectable		 4aztA-2pvzA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		 2pvz PRPF METHYLACONITATE
ISOMERASE
(Shewanella
oneidensis) 		4 / 6 LYS A  59
ALA A  67
SER A  69
THR A  71
 CA  A1002 (-3.3A)
None
CA  A1003 (-3.3A)
None
 1.15A 4d7bB-2pvzA:
undetectable		 4d7bB-2pvzA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_A_1FLA201_1
(TRANSTHYRETIN)		 2pvz PRPF METHYLACONITATE
ISOMERASE
(Shewanella
oneidensis) 		4 / 6 LYS A  59
ALA A  67
SER A  69
THR A  71
 CA  A1002 (-3.3A)
None
CA  A1003 (-3.3A)
None
 1.04A 4i89A-2pvzA:
undetectable		 4i89A-2pvzA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_B_1FLB201_1
(TRANSTHYRETIN)		 2pvz PRPF METHYLACONITATE
ISOMERASE
(Shewanella
oneidensis) 		4 / 4 LYS A  59
ALA A  67
SER A  69
THR A  71
 CA  A1002 (-3.3A)
None
CA  A1003 (-3.3A)
None
 1.17A 4i89B-2pvzA:
0.0		 4i89B-2pvzA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J14_A_X2NA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 2pvz PRPF METHYLACONITATE
ISOMERASE
(Shewanella
oneidensis) 		5 / 10 ALA A 343
LEU A 306
ALA A 283
THR A 224
ALA A 327
 None
 0.93A 4j14A-2pvzA:
undetectable		 4j14A-2pvzA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_2
(NEURAMINIDASE)		 2pvz PRPF METHYLACONITATE
ISOMERASE
(Shewanella
oneidensis) 		3 / 3 ARG A  43
TRP A 103
ILE A  76
 None
 0.91A 4mwxA-2pvzA:
undetectable		 4mwxA-2pvzA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_1
(ANDROGEN RECEPTOR)		 2pvz PRPF METHYLACONITATE
ISOMERASE
(Shewanella
oneidensis) 		5 / 12 LEU A  29
VAL A  75
ARG A  43
ILE A 124
VAL A 137
 CA  A1004 (-4.7A)
None
None
None
None
 1.31A 4okwA-2pvzA:
undetectable		 4okwA-2pvzA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XPB_A_COCA702_1
(TRANSPORTER)		 2pvz PRPF METHYLACONITATE
ISOMERASE
(Shewanella
oneidensis) 		5 / 10 VAL A  75
TYR A  89
SER A  22
GLY A  24
MET A  17
 None
None
EDO  A1005 (-2.6A)
None
None
 1.40A 4xpbA-2pvzA:
undetectable		 4xpbA-2pvzA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 2pvz PRPF METHYLACONITATE
ISOMERASE
(Shewanella
oneidensis) 		3 / 3 HIS A 355
SER A 312
ASN A 109
 None
CA  A1003 (-3.2A)
EDO  A1005 (-4.0A)
 0.90A 5cprB-2pvzA:
undetectable		 5cprB-2pvzA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_A_ILEA601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2pvz PRPF METHYLACONITATE
ISOMERASE
(Shewanella
oneidensis) 		4 / 6 ALA A 112
THR A 111
VAL A 114
TYR A  89
 None
 1.07A 5eckA-2pvzA:
1.6		 5eckA-2pvzA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_A_ILEA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2pvz PRPF METHYLACONITATE
ISOMERASE
(Shewanella
oneidensis) 		4 / 6 ALA A 112
THR A 111
VAL A 114
TYR A  89
 None
 1.02A 5eclA-2pvzA:
undetectable		 5eclA-2pvzA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESH_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2pvz PRPF METHYLACONITATE
ISOMERASE
(Shewanella
oneidensis) 		5 / 12 ALA A 113
LEU A 110
PHE A 226
ILE A 218
PHE A 181
 None
 1.19A 5eshA-2pvzA:
undetectable		 5eshA-2pvzA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 2pvz PRPF METHYLACONITATE
ISOMERASE
(Shewanella
oneidensis) 		4 / 7 THR A 323
GLN A 141
ILE A 148
GLY A 108
 EDO  A1005 (-3.1A)
None
None
EDO  A1005 (-3.8A)
 0.98A 5nzyA-2pvzA:
undetectable		 5nzyA-2pvzA:
23.17