SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pw6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S1X_A_NVPA999_1
(REVERSE
TRANSCRIPTASE)		 2pw6 UNCHARACTERIZED
PROTEIN YGID
(Escherichia
coli) 		4 / 8 LEU A 238
GLY A 243
LEU A 216
TYR A 235
 None
 0.96A 1s1xA-2pw6A:
undetectable		 1s1xA-2pw6A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_0
(HEMK PROTEIN)		 2pw6 UNCHARACTERIZED
PROTEIN YGID
(Escherichia
coli) 		5 / 12 GLY A  21
GLY A 173
VAL A 126
SER A 123
ALA A 171
 None
 1.00A 1sg9B-2pw6A:
undetectable		 1sg9B-2pw6A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDN_A_LEUA487_0
(L-AMINO ACID OXIDASE)		 2pw6 UNCHARACTERIZED
PROTEIN YGID
(Escherichia
coli) 		4 / 7 ARG A 157
HIS A 214
PHE A 153
ILE A 251
 None
 1.32A 1tdnA-2pw6A:
undetectable		 1tdnA-2pw6A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 2pw6 UNCHARACTERIZED
PROTEIN YGID
(Escherichia
coli) 		5 / 12 GLY A 173
GLY A 125
GLY A  23
GLY A  21
ILE A 128
 None
 0.91A 2oxtA-2pw6A:
undetectable		 2oxtA-2pw6A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		 2pw6 UNCHARACTERIZED
PROTEIN YGID
(Escherichia
coli) 		3 / 3 HIS A 234
HIS A  22
HIS A  57
 ZN  A 272 (-3.2A)
ZN  A 272 (-3.6A)
ZN  A 272 (-3.4A)
 0.55A 2ozrF-2pw6A:
undetectable		 2ozrF-2pw6A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DLC_A_SAMA220_0
(PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE)		 2pw6 UNCHARACTERIZED
PROTEIN YGID
(Escherichia
coli) 		5 / 12 TYR A 235
GLY A  21
GLY A 173
SER A 123
SER A 267
 None
 1.30A 3dlcA-2pw6A:
undetectable		 3dlcA-2pw6A:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2pw6 UNCHARACTERIZED
PROTEIN YGID
(Escherichia
coli) 		5 / 12 ASP A 120
LEU A 263
ASN A 174
GLY A  21
HIS A  22
 None
None
None
None
ZN  A 272 (-3.6A)
 1.29A 4pgfA-2pw6A:
undetectable		 4pgfA-2pw6A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2pw6 UNCHARACTERIZED
PROTEIN YGID
(Escherichia
coli) 		4 / 8 PRO A 254
LEU A  18
VAL A 126
LEU A  45
 None
 0.88A 4pwdA-2pw6A:
undetectable		 4pwdA-2pw6A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 2pw6 UNCHARACTERIZED
PROTEIN YGID
(Escherichia
coli) 		4 / 7 LEU A 238
GLU A 233
ASN A 198
ILE A 258
 None
ZN  A 274 ( 4.6A)
None
None
 1.10A 5jh7C-2pw6A:
undetectable		 5jh7C-2pw6A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2pw6 UNCHARACTERIZED
PROTEIN YGID
(Escherichia
coli) 		4 / 5 GLY A 225
THR A 226
GLY A 247
LEU A 238
 None
 0.91A 5jlcA-2pw6A:
undetectable		 5jlcA-2pw6A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_2
(ENVELOPE
GLYCOPROTEIN 2)		 2pw6 UNCHARACTERIZED
PROTEIN YGID
(Escherichia
coli) 		4 / 7 LEU A 159
TYR A 240
MET A 155
LEU A 101
 None
 1.00A 5jq7B-2pw6A:
undetectable		 5jq7B-2pw6A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA604_0
(THIOCYANATE
DEHYDROGENASE)		 2pw6 UNCHARACTERIZED
PROTEIN YGID
(Escherichia
coli) 		3 / 3 HIS A  22
HIS A 234
HIS A 177
 ZN  A 272 (-3.6A)
ZN  A 272 (-3.2A)
ZN  A 274 (-3.1A)
 1.02A 5oexA-2pw6A:
undetectable		 5oexA-2pw6A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC607_0
(ALPHA-AMYLASE)		 2pw6 UNCHARACTERIZED
PROTEIN YGID
(Escherichia
coli) 		4 / 6 GLY A  21
TRP A  38
GLY A 122
GLY A 125
 None
 0.75A 6ag0C-2pw6A:
undetectable		 6ag0C-2pw6A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		 2pw6 UNCHARACTERIZED
PROTEIN YGID
(Escherichia
coli) 		4 / 6 THR A 111
LEU A 112
THR A  60
LEU A 105
 None
 1.13A 6mvxA-2pw6A:
undetectable
6mvxB-2pw6A:
undetectable
6mvxC-2pw6A:
undetectable		 6mvxA-2pw6A:
21.24
6mvxB-2pw6A:
21.24
6mvxC-2pw6A:
21.24