SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pw9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9J_H_TESH1010_1
(RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT HEAVY
CHAIN
RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT LIGHT
CHAIN)		 2pw9 PUTATIVE FORMATE
DEHYDROGENASE
ACCESSORY PROTEIN
(Desulfotalea
psychrophila) 		5 / 11 VAL A  49
TYR A  35
GLY A  60
LEU A  62
VAL A  79
 None
 1.43A 1i9jH-2pw9A:
undetectable
1i9jL-2pw9A:
undetectable		 1i9jH-2pw9A:
19.42
1i9jL-2pw9A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2pw9 PUTATIVE FORMATE
DEHYDROGENASE
ACCESSORY PROTEIN
(Desulfotalea
psychrophila) 		5 / 11 LEU A 164
PHE A 136
SER A 144
VAL A 153
VAL A 180
 None
 1.24A 2po5B-2pw9A:
undetectable		 2po5B-2pw9A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA1_0
(FERROCHELATASE)		 2pw9 PUTATIVE FORMATE
DEHYDROGENASE
ACCESSORY PROTEIN
(Desulfotalea
psychrophila) 		5 / 11 LEU A 164
PHE A 136
SER A 144
VAL A 153
VAL A 180
 None
 1.32A 3aqiA-2pw9A:
undetectable		 3aqiA-2pw9A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 2pw9 PUTATIVE FORMATE
DEHYDROGENASE
ACCESSORY PROTEIN
(Desulfotalea
psychrophila) 		5 / 10 LEU A 158
SER A 190
ILE A 214
PRO A 215
GLY A 213
 None
 1.40A 3ijxB-2pw9A:
undetectable
3ijxD-2pw9A:
undetectable		 3ijxB-2pw9A:
21.83
3ijxD-2pw9A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB262_1
(GLUTAMATE RECEPTOR 2)		 2pw9 PUTATIVE FORMATE
DEHYDROGENASE
ACCESSORY PROTEIN
(Desulfotalea
psychrophila) 		5 / 10 ILE A 214
PRO A 215
GLY A 213
LEU A 158
SER A 190
 None
 1.34A 3ik6B-2pw9A:
undetectable
3ik6E-2pw9A:
undetectable		 3ik6B-2pw9A:
21.83
3ik6E-2pw9A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)		 2pw9 PUTATIVE FORMATE
DEHYDROGENASE
ACCESSORY PROTEIN
(Desulfotalea
psychrophila) 		5 / 10 LEU A 158
SER A 190
ILE A 214
PRO A 215
GLY A 213
 None
 1.35A 3iluB-2pw9A:
undetectable
3iluE-2pw9A:
undetectable		 3iluB-2pw9A:
21.83
3iluE-2pw9A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OAP_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2pw9 PUTATIVE FORMATE
DEHYDROGENASE
ACCESSORY PROTEIN
(Desulfotalea
psychrophila) 		5 / 12 ILE A 217
ALA A 231
LEU A 201
ILE A 212
LEU A 123
 None
 0.98A 3oapA-2pw9A:
undetectable		 3oapA-2pw9A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2pw9 PUTATIVE FORMATE
DEHYDROGENASE
ACCESSORY PROTEIN
(Desulfotalea
psychrophila) 		5 / 12 LEU A 201
VAL A 180
PHE A 136
ILE A 256
ILE A 216
 None
 1.15A 3w68C-2pw9A:
undetectable		 3w68C-2pw9A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 2pw9 PUTATIVE FORMATE
DEHYDROGENASE
ACCESSORY PROTEIN
(Desulfotalea
psychrophila) 		5 / 12 GLY A 157
ILE A 137
SER A 193
ALA A 194
TRP A 159
 None
 1.15A 4qtuD-2pw9A:
undetectable		 4qtuD-2pw9A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESE_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2pw9 PUTATIVE FORMATE
DEHYDROGENASE
ACCESSORY PROTEIN
(Desulfotalea
psychrophila) 		5 / 8 TYR A 126
LEU A 128
ILE A 214
PHE A 136
GLY A 157
 None
 1.36A 5eseA-2pw9A:
1.2		 5eseA-2pw9A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2pw9 PUTATIVE FORMATE
DEHYDROGENASE
ACCESSORY PROTEIN
(Desulfotalea
psychrophila) 		5 / 12 GLY A 172
HIS A 174
VAL A 177
PHE A  57
VAL A  52
 None
 1.27A 5n0xB-2pw9A:
undetectable		 5n0xB-2pw9A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_H_EZLH303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2pw9 PUTATIVE FORMATE
DEHYDROGENASE
ACCESSORY PROTEIN
(Desulfotalea
psychrophila) 		4 / 8 HIS A 174
VAL A 177
LEU A 201
THR A 202
 None
 0.83A 5tt3H-2pw9A:
undetectable		 5tt3H-2pw9A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_2
(CYTOCHROME P450 3A5)		 2pw9 PUTATIVE FORMATE
DEHYDROGENASE
ACCESSORY PROTEIN
(Desulfotalea
psychrophila) 		3 / 3 ARG A  75
PHE A  63
LEU A  39
 None
 0.77A 5veuA-2pw9A:
undetectable		 5veuA-2pw9A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YK2_A_ERYA501_0
(PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER)		 2pw9 PUTATIVE FORMATE
DEHYDROGENASE
ACCESSORY PROTEIN
(Desulfotalea
psychrophila) 		5 / 11 GLU A  72
GLU A  73
GLY A 182
ALA A  59
ILE A 212
 None
 1.13A 5yk2A-2pw9A:
undetectable		 5yk2A-2pw9A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_B_BEZB201_0
(NS3 PROTEASE)		 2pw9 PUTATIVE FORMATE
DEHYDROGENASE
ACCESSORY PROTEIN
(Desulfotalea
psychrophila) 		4 / 5 HIS A 168
ALA A 189
SER A 183
GLY A 182
 None
 1.14A 5yodB-2pw9A:
undetectable		 5yodB-2pw9A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_D_BEZD201_0
(NS3 PROTEASE)		 2pw9 PUTATIVE FORMATE
DEHYDROGENASE
ACCESSORY PROTEIN
(Desulfotalea
psychrophila) 		4 / 5 HIS A 168
ALA A 189
SER A 183
GLY A 182
 None
 1.28A 5yodD-2pw9A:
undetectable		 5yodD-2pw9A:
21.37