SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pwq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 2pwq UBIQUITIN
CONJUGATING ENZYME
(Plasmodium
yoelii) 		5 / 12 ILE A  86
LEU A  91
LEU A 105
ILE A 101
PHE A  70
 None
 1.18A 1xzxX-2pwqA:
undetectable		 1xzxX-2pwqA:
25.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_A_SAMA500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 2pwq UBIQUITIN
CONJUGATING ENZYME
(Plasmodium
yoelii) 		5 / 11 ALA A 140
ILE A  74
ALA A 148
PRO A  45
PHE A 136
 None
 1.23A 2admA-2pwqA:
undetectable		 2admA-2pwqA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_B_SAMB500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 2pwq UBIQUITIN
CONJUGATING ENZYME
(Plasmodium
yoelii) 		5 / 11 ALA A 140
ILE A  74
ALA A 148
PRO A  45
PHE A 136
 None
 1.25A 2admB-2pwqA:
undetectable		 2admB-2pwqA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H77_A_T3A1_1
(THRA PROTEIN)		 2pwq UBIQUITIN
CONJUGATING ENZYME
(Plasmodium
yoelii) 		5 / 12 ILE A  86
LEU A  91
LEU A 105
ILE A 101
PHE A  70
 None
 1.11A 2h77A-2pwqA:
undetectable		 2h77A-2pwqA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA508_0
(CHORISMATE SYNTHASE)		 2pwq UBIQUITIN
CONJUGATING ENZYME
(Plasmodium
yoelii) 		4 / 5 LEU A 105
ARG A 102
ALA A 104
ILE A  14
 None
 0.93A 2qhfA-2pwqA:
undetectable		 2qhfA-2pwqA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HDL_A_DXCA75_0
(PPCA)		 2pwq UBIQUITIN
CONJUGATING ENZYME
(Plasmodium
yoelii) 		4 / 8 ILE A  14
LYS A  69
ILE A  38
PHE A  37
 None
 0.87A 4hdlA-2pwqA:
undetectable		 4hdlA-2pwqA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 2pwq UBIQUITIN
CONJUGATING ENZYME
(Plasmodium
yoelii) 		5 / 12 ILE A  86
LEU A  91
LEU A 105
ILE A 101
PHE A  70
 None
 1.15A 4lnwA-2pwqA:
undetectable		 4lnwA-2pwqA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 2pwq UBIQUITIN
CONJUGATING ENZYME
(Plasmodium
yoelii) 		5 / 12 ILE A  86
LEU A  91
LEU A 105
ILE A 101
PHE A  70
 None
 1.16A 4lnxA-2pwqA:
undetectable		 4lnxA-2pwqA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD4_C_AOQC4003_1
(CYTOCHROME B)		 2pwq UBIQUITIN
CONJUGATING ENZYME
(Plasmodium
yoelii) 		5 / 12 PHE A  51
ILE A  74
PRO A  41
LEU A 111
ILE A  68
 None
 0.97A 4pd4C-2pwqA:
undetectable		 4pd4C-2pwqA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_J_Z80J401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2pwq UBIQUITIN
CONJUGATING ENZYME
(Plasmodium
yoelii) 		5 / 12 ILE A  14
PHE A  37
ASN A  30
GLU A  33
ILE A  55
 None
 1.17A 5lg3J-2pwqA:
undetectable		 5lg3J-2pwqA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_B_IXXB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 2pwq UBIQUITIN
CONJUGATING ENZYME
(Plasmodium
yoelii) 		4 / 5 ARG A 102
ALA A  24
GLN A 109
ILE A  38
 None
 1.35A 6g9bA-2pwqA:
undetectable
6g9bB-2pwqA:
undetectable		 6g9bA-2pwqA:
15.45
6g9bB-2pwqA:
20.10