SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pwz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CET_A_CLQA1001_0
(PROTEIN (L-LACTATE
DEHYDROGENASE))		 2pwz MALATE DEHYDROGENASE
(Escherichia
coli) 		5 / 9 GLY A   7
ASP A  34
ILE A  35
ALA A  77
ILE A  97
 None
 0.60A 1cetA-2pwzA:
32.7		 1cetA-2pwzA:
29.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3004_0
(BETA-CARBONIC
ANHYDRASE)		 2pwz MALATE DEHYDROGENASE
(Escherichia
coli) 		4 / 6 TYR A 253
ASP A 302
VAL A 121
GLY A 176
 None
 1.27A 1ekjC-2pwzA:
2.3
1ekjD-2pwzA:
2.3		 1ekjC-2pwzA:
25.24
1ekjD-2pwzA:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3007_0
(BETA-CARBONIC
ANHYDRASE)		 2pwz MALATE DEHYDROGENASE
(Escherichia
coli) 		4 / 6 ASP A 302
VAL A 121
GLY A 176
TYR A 253
 None
 1.28A 1ekjC-2pwzA:
2.3
1ekjD-2pwzA:
2.3		 1ekjC-2pwzA:
25.24
1ekjD-2pwzA:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX9_A_REAA1163_1
(BETA-LACTOGLOBULIN)		 2pwz MALATE DEHYDROGENASE
(Escherichia
coli) 		5 / 11 LEU A 185
VAL A 171
ILE A 206
VAL A 199
PHE A 194
 None
 1.32A 1gx9A-2pwzA:
undetectable		 1gx9A-2pwzA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_2
(HIV-II PROTEASE)		 2pwz MALATE DEHYDROGENASE
(Escherichia
coli) 		5 / 8 ALA A 128
GLY A 306
ILE A 303
PRO A 120
ILE A 116
 None
 1.50A 1hshD-2pwzA:
undetectable		 1hshD-2pwzA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_2
(PROTEASE)		 2pwz MALATE DEHYDROGENASE
(Escherichia
coli) 		4 / 6 ASN A  94
GLY A  10
ILE A  12
ILE A  97
 None
 0.93A 1n49D-2pwzA:
undetectable		 1n49D-2pwzA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		 2pwz MALATE DEHYDROGENASE
(Escherichia
coli) 		4 / 5 PRO A 184
VAL A 171
VAL A 158
ILE A 206
 None
 1.05A 1z2bC-2pwzA:
5.7		 1z2bC-2pwzA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMY_B_SAMB328_0
(PROTEIN
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI))		 2pwz MALATE DEHYDROGENASE
(Escherichia
coli) 		5 / 12 PHE A 264
GLY A 256
ILE A 281
LEU A 292
TYR A 138
 None
 1.04A 2hmyB-2pwzA:
5.2		 2hmyB-2pwzA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2pwz MALATE DEHYDROGENASE
(Escherichia
coli) 		5 / 11 LEU A 238
PHE A 234
LEU A 132
VAL A 102
VAL A 254
 None
 1.22A 2po5B-2pwzA:
3.0		 2po5B-2pwzA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFX_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 2pwz MALATE DEHYDROGENASE
(Escherichia
coli) 		5 / 8 LEU A 268
ALA A 252
GLY A 274
LEU A 238
GLY A 235
 None
 1.20A 2yfxA-2pwzA:
undetectable		 2yfxA-2pwzA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		 2pwz MALATE DEHYDROGENASE
(Escherichia
coli) 		3 / 3 LEU A 143
GLU A 130
ILE A 127
 None
 0.55A 3czhA-2pwzA:
undetectable		 3czhA-2pwzA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKX_B_1UNB201_2
(PROTEASE)		 2pwz MALATE DEHYDROGENASE
(Escherichia
coli) 		5 / 11 ALA A  77
VAL A  98
ILE A 116
VAL A  93
ILE A  97
 None
 0.92A 3ekxB-2pwzA:
undetectable		 3ekxB-2pwzA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2pwz MALATE DEHYDROGENASE
(Escherichia
coli) 		5 / 12 ILE A  75
GLY A 145
PHE A 144
LEU A 238
LEU A  16
 None
 1.08A 3em0B-2pwzA:
undetectable		 3em0B-2pwzA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 2pwz MALATE DEHYDROGENASE
(Escherichia
coli) 		5 / 10 ALA A   4
LEU A 101
VAL A 105
ILE A 116
ILE A 114
 None
 1.07A 3jw3A-2pwzA:
undetectable		 3jw3A-2pwzA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_A_BEZA264_0
(CARNITINYL-COA
DEHYDRATASE)		 2pwz MALATE DEHYDROGENASE
(Escherichia
coli) 		4 / 6 ALA A 128
ILE A 116
LEU A 143
ALA A 106
 None
 0.70A 3r9sA-2pwzA:
undetectable		 3r9sA-2pwzA:
25.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_B_ADNB301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 2pwz MALATE DEHYDROGENASE
(Escherichia
coli) 		5 / 10 ALA A   9
GLY A  13
LEU A  46
LEU A  32
LEU A  16
 None
 1.17A 3wdmB-2pwzA:
3.4		 3wdmB-2pwzA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_C_ADNC301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 2pwz MALATE DEHYDROGENASE
(Escherichia
coli) 		5 / 9 ALA A   9
GLY A  13
LEU A  46
LEU A  32
LEU A  16
 None
 1.01A 3wdmC-2pwzA:
3.4		 3wdmC-2pwzA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_A_RBFA201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2pwz MALATE DEHYDROGENASE
(Escherichia
coli) 		4 / 8 THR A 147
ILE A 206
LEU A 185
ILE A 281
 None
 0.81A 4r38A-2pwzA:
undetectable		 4r38A-2pwzA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2pwz MALATE DEHYDROGENASE
(Escherichia
coli) 		6 / 12 VAL A 102
LEU A 101
ALA A  66
VAL A  73
GLY A 115
LEU A 143
 None
 1.41A 5kirA-2pwzA:
undetectable		 5kirA-2pwzA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_D_SAMD201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 2pwz MALATE DEHYDROGENASE
(Escherichia
coli) 		5 / 11 LEU A   6
ASP A  34
ILE A  35
ILE A  75
GLY A  78
 None
 0.81A 5twjD-2pwzA:
undetectable		 5twjD-2pwzA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_1
(CYTOCHROME P450 3A4)		 2pwz MALATE DEHYDROGENASE
(Escherichia
coli) 		5 / 12 SER A  76
ILE A 117
ALA A   9
THR A  39
ALA A  66
 None
 1.13A 5vceA-2pwzA:
undetectable		 5vceA-2pwzA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2pwz MALATE DEHYDROGENASE
(Escherichia
coli) 		5 / 12 VAL A   5
LEU A  74
GLY A 228
SER A 226
ILE A  12
 None
 1.19A 5vopB-2pwzA:
2.5		 5vopB-2pwzA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z3J_A_NCAA302_0
(ABRIN A-CHAIN)		 2pwz MALATE DEHYDROGENASE
(Escherichia
coli) 		4 / 6 VAL A 125
TYR A 138
GLU A 255
ARG A 262
 None
 0.86A 5z3jA-2pwzA:
undetectable		 5z3jA-2pwzA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 2pwz MALATE DEHYDROGENASE
(Escherichia
coli) 		5 / 12 SER A  31
GLY A  13
ALA A   8
GLU A 250
VAL A  72
 None
 1.20A 6bqgA-2pwzA:
undetectable		 6bqgA-2pwzA:
14.48