SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2px0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_A_SAMA1401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 2px0 FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHF
(Bacillus
subtilis) 		5 / 11 GLY A 340
TYR A 314
ILE A 337
PRO A 310
LEU A 274
 None
 1.23A 1p91A-2px0A:
undetectable		 1p91A-2px0A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2px0 FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHF
(Bacillus
subtilis) 		5 / 12 ILE A 173
ALA A 208
PHE A 209
LEU A 230
MET A 200
 None
 0.99A 1uduB-2px0A:
undetectable		 1uduB-2px0A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPO_H_TESH1010_1
(ANTI-TESTOSTERONE
(HEAVY CHAIN)
ANTI-TESTOSTERONE
(LIGHT CHAIN))		 2px0 FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHF
(Bacillus
subtilis) 		5 / 12 SER A 335
ALA A 333
TYR A 296
LEU A 332
PHE A 316
 None
 1.30A 1vpoH-2px0A:
undetectable
1vpoL-2px0A:
undetectable		 1vpoH-2px0A:
23.28
1vpoL-2px0A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		 2px0 FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHF
(Bacillus
subtilis) 		5 / 12 LEU A 364
MET A 363
PHE A 360
PHE A 316
MET A 342
 None
 1.38A 2jj8C-2px0A:
1.9		 2jj8C-2px0A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 2px0 FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHF
(Bacillus
subtilis) 		4 / 7 LEU A 325
VAL A 355
LEU A 332
LEU A 180
 None
 0.82A 3g8iA-2px0A:
undetectable		 3g8iA-2px0A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2px0 FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHF
(Bacillus
subtilis) 		5 / 12 LEU A 288
GLY A 187
GLY A 182
SER A 183
ALA A 193
 None
GNP  A   1 ( 3.2A)
None
None
None
 1.12A 3ou6A-2px0A:
undetectable		 3ou6A-2px0A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2px0 FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHF
(Bacillus
subtilis) 		5 / 12 LEU A 288
GLY A 187
GLY A 182
SER A 183
ALA A 193
 None
GNP  A   1 ( 3.2A)
None
None
None
 1.10A 3ou7B-2px0A:
undetectable		 3ou7B-2px0A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA602_1
(SERUM ALBUMIN)		 2px0 FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHF
(Bacillus
subtilis) 		4 / 8 LYS A 114
ALA A 115
LEU A 119
LEU A 133
 None
 0.66A 4po0A-2px0A:
4.1		 4po0A-2px0A:
18.64