SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2px7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_A_BEZA11_0
(CES1 PROTEIN)		 2px7 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Thermus
thermophilus) 		4 / 4 LEU A  85
SER A 111
LEU A  87
LEU A 105
 None
 1.14A 1yajA-2px7A:
undetectable		 1yajA-2px7A:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEO_A_017A402_2
(PROTEASE)		 2px7 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Thermus
thermophilus) 		5 / 12 LEU A 185
ALA A 173
ASP A 172
VAL A 117
VAL A 115
 None
 0.86A 2ieoB-2px7A:
undetectable		 2ieoB-2px7A:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD37_0
(GCN4 LEUCINE ZIPPER)		 2px7 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Thermus
thermophilus) 		3 / 3 LYS A  21
ARG A  93
VAL A  91
 None
 1.06A 2r2vC-2px7A:
undetectable
2r2vD-2px7A:
undetectable		 2r2vC-2px7A:
10.34
2r2vD-2px7A:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_D_BEZD1221_0
(PEROXIREDOXIN 6)		 2px7 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Thermus
thermophilus) 		5 / 8 VAL A 115
PRO A 116
THR A 146
VAL A  88
ARG A  70
 None
 1.42A 2v32C-2px7A:
undetectable
2v32D-2px7A:
undetectable		 2v32C-2px7A:
21.96
2v32D-2px7A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		 2px7 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Thermus
thermophilus) 		5 / 12 LEU A  36
LEU A  32
ALA A   9
LEU A  77
THR A 146
 None
 1.15A 3gwuA-2px7A:
undetectable		 3gwuA-2px7A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_D_9PLD1_1
(CYTOCHROME P450 2A13)		 2px7 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Thermus
thermophilus) 		4 / 8 PHE A  63
ALA A  53
ALA A  22
THR A  30
 None
 0.95A 3t3sD-2px7A:
undetectable		 3t3sD-2px7A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_F_9PLF1_1
(CYTOCHROME P450 2A13)		 2px7 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Thermus
thermophilus) 		4 / 8 PHE A  63
ALA A  53
ALA A  22
THR A  30
 None
 1.00A 3t3sF-2px7A:
undetectable		 3t3sF-2px7A:
18.79