SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2px9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R5L_A_VIVA301_1
(PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN))		 2px9 SUMO-ACTIVATING
ENZYME SUBUNIT 2
(Homo
sapiens) 		4 / 4 SER A 323
SER A 325
LEU A 361
PHE A 354
 None
 1.43A 1r5lA-2px9A:
undetectable		 1r5lA-2px9A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_A_VIBA223_1
(THIAMINE
PYROPHOSPHOKINASE)		 2px9 SUMO-ACTIVATING
ENZYME SUBUNIT 2
(Homo
sapiens) 		4 / 7 LEU A 313
LEU A 321
ASN A 360
ASP A 353
 None
 0.92A 3lm8A-2px9A:
undetectable
3lm8C-2px9A:
undetectable		 3lm8A-2px9A:
21.54
3lm8C-2px9A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_D_VIBD223_1
(THIAMINE
PYROPHOSPHOKINASE)		 2px9 SUMO-ACTIVATING
ENZYME SUBUNIT 2
(Homo
sapiens) 		4 / 8 ASP A 353
LEU A 313
LEU A 321
ASN A 360
 None
 0.91A 3lm8B-2px9A:
undetectable
3lm8D-2px9A:
undetectable		 3lm8B-2px9A:
21.54
3lm8D-2px9A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		 2px9 SUMO-ACTIVATING
ENZYME SUBUNIT 2
(Homo
sapiens) 		5 / 10 ILE A 326
ASN A 360
ALA A 358
LEU A 196
LEU A 192
 None
 1.16A 3o02A-2px9A:
undetectable
3o02B-2px9A:
undetectable		 3o02A-2px9A:
21.27
3o02B-2px9A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 2px9 SUMO-ACTIVATING
ENZYME SUBUNIT 2
(Homo
sapiens) 		4 / 7 THR A 247
LEU A 192
GLN A 204
GLU A 199
 None
 0.96A 5tudA-2px9A:
2.1		 5tudA-2px9A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_D95A816_0
(GEPHYRIN)		 2px9 SUMO-ACTIVATING
ENZYME SUBUNIT 2
(Homo
sapiens) 		5 / 11 ILE A 175
LEU A 258
ARG A 176
PRO A 208
ILE A 238
 None
 1.50A 6fgcA-2px9A:
undetectable		 6fgcA-2px9A:
16.06