SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pxj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA734_1
(ALPHA AMYLASE)		 2pxj JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 3A
(Homo
sapiens) 		4 / 6 ASN A 149
TRP A  53
HIS A 201
TYR A 199
 None
 1.36A 1mxdA-2pxjA:
undetectable		 1mxdA-2pxjA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA444_1
(ALPHA AMYLASE)		 2pxj JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 3A
(Homo
sapiens) 		4 / 7 ASN A 149
TRP A  53
HIS A 201
TYR A 199
 None
 1.37A 1mxgA-2pxjA:
undetectable		 1mxgA-2pxjA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUA_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 2pxj JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 3A
(Homo
sapiens) 		5 / 10 ALA A 286
TRP A 208
LEU A 200
GLY A 265
PHE A 267
 None
 1.39A 1ruaH-2pxjA:
undetectable
1ruaL-2pxjA:
undetectable		 1ruaH-2pxjA:
20.87
1ruaL-2pxjA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UUJ_B_ACTB1077_0
(PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
ALPHA SUBUNIT)		 2pxj JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 3A
(Homo
sapiens) 		3 / 3 ARG A 322
TYR A 329
LYS A 333
 None
 0.99A 1uujB-2pxjA:
undetectable		 1uujB-2pxjA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1502_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 2pxj JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 3A
(Homo
sapiens) 		4 / 5 PRO A 130
GLY A 282
ASN A 280
GLY A 179
 None
 1.07A 1zlqA-2pxjA:
undetectable		 1zlqA-2pxjA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6001_0
(PANTOTHENATE KINASE)		 2pxj JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 3A
(Homo
sapiens) 		5 / 11 TYR A 141
GLY A 151
THR A 289
ILE A 197
ARG A 154
 None
 1.46A 2f9wA-2pxjA:
undetectable
2f9wB-2pxjA:
undetectable		 2f9wA-2pxjA:
23.76
2f9wB-2pxjA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 2pxj JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 3A
(Homo
sapiens) 		4 / 7 TYR A 275
THR A 189
TYR A 273
ASP A 191
 None
 1.09A 2g70A-2pxjA:
undetectable		 2g70A-2pxjA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 2pxj JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 3A
(Homo
sapiens) 		4 / 7 TYR A 275
THR A 189
TYR A 273
ASP A 191
 None
 1.09A 2g70B-2pxjA:
undetectable		 2g70B-2pxjA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA802_0
(FERROCHELATASE)		 2pxj JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 3A
(Homo
sapiens) 		4 / 6 ARG A 152
ARG A 154
PRO A  19
MET A  21
 None
 1.38A 2qd4A-2pxjA:
0.0		 2qd4A-2pxjA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_A_ACRA5044_2
(GLUCOSYLTRANSFERASE-
SI)		 2pxj JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 3A
(Homo
sapiens) 		3 / 3 LEU A 117
TRP A 208
TYR A 121
 None
 0.99A 3aicA-2pxjA:
undetectable		 3aicA-2pxjA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_2
(GLUCOSYLTRANSFERASE-
SI)		 2pxj JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 3A
(Homo
sapiens) 		3 / 3 LEU A 117
TRP A 208
TYR A 121
 None
 0.98A 3aicB-2pxjA:
undetectable		 3aicB-2pxjA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_2
(GLUCOSYLTRANSFERASE-
SI)		 2pxj JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 3A
(Homo
sapiens) 		3 / 3 LEU A 117
TRP A 208
TYR A 121
 None
 0.98A 3aicE-2pxjA:
undetectable		 3aicE-2pxjA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_F_ACRF5044_2
(GLUCOSYLTRANSFERASE-
SI)		 2pxj JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 3A
(Homo
sapiens) 		3 / 3 LEU A 117
TRP A 208
TYR A 121
 None
 0.99A 3aicF-2pxjA:
undetectable		 3aicF-2pxjA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_G_ACRG5044_2
(GLUCOSYLTRANSFERASE-
SI)		 2pxj JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 3A
(Homo
sapiens) 		3 / 3 LEU A 117
TRP A 208
TYR A 121
 None
 0.97A 3aicG-2pxjA:
undetectable		 3aicG-2pxjA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_2
(GLUCOSYLTRANSFERASE-
SI)		 2pxj JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 3A
(Homo
sapiens) 		3 / 3 LEU A 117
TRP A 208
TYR A 121
 None
 0.96A 3aicH-2pxjA:
undetectable		 3aicH-2pxjA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J7Z_A_ERYA9000_0
(23S RRNA
50S RIBOSOMAL
PROTEIN L22
ERMCL NASCENT CHAIN)		 2pxj JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 3A
(Homo
sapiens) 		3 / 3 LYS A 241
ILE A 269
PHE A 267
 None
 0.95A 3j7zS-2pxjA:
undetectable
3j7za-2pxjA:
undetectable		 3j7zS-2pxjA:
16.56
3j7za-2pxjA:
5.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP1_A_ACTA590_0
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 2pxj JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 3A
(Homo
sapiens) 		4 / 5 GLU A   6
LEU A   8
HIS A  40
GLY A  38
 None
 1.00A 3pp1A-2pxjA:
undetectable		 3pp1A-2pxjA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2pxj JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 3A
(Homo
sapiens) 		4 / 5 TYR A 141
SER A 288
ASP A  61
ILE A  62
 None
OGA  A5001 (-3.5A)
None
None
 1.34A 3uj7B-2pxjA:
undetectable		 3uj7B-2pxjA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2pxj JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 3A
(Homo
sapiens) 		4 / 8 GLN A  73
ILE A  67
VAL A  94
PHE A  97
 None
 1.00A 4dx7B-2pxjA:
undetectable		 4dx7B-2pxjA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRK_A_KTRA713_1
(LACTOTRANSFERRIN)		 2pxj JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 3A
(Homo
sapiens) 		4 / 5 GLY A 216
VAL A 211
PRO A 213
TYR A 299
 None
 1.08A 4grkA-2pxjA:
undetectable		 4grkA-2pxjA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2pxj JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 3A
(Homo
sapiens) 		5 / 12 SER A 196
LEU A  44
VAL A 260
PHE A 185
HIS A 188
 OGA  A5001 (-2.7A)
None
None
OGA  A5001 (-3.8A)
FE2  A3001 ( 3.5A)
 1.22A 4o8fB-2pxjA:
undetectable		 4o8fB-2pxjA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_A_STRA601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 2pxj JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 3A
(Homo
sapiens) 		4 / 6 ALA A 292
GLY A 300
ILE A 156
VAL A 321
 None
 0.77A 4r21A-2pxjA:
undetectable		 4r21A-2pxjA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_F_URFF301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 2pxj JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 3A
(Homo
sapiens) 		3 / 3 ARG A 221
HIS A 215
ARG A 218
 None
 1.03A 5iaoF-2pxjA:
undetectable		 5iaoF-2pxjA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MXB_A_ML1A222_1
(CLASS 10 PLANT
PATHOGENESIS-RELATED
PROTEIN)		 2pxj JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 3A
(Homo
sapiens) 		5 / 10 VAL A  94
ILE A  62
LEU A 140
GLY A 179
PHE A 178
 None
 1.16A 5mxbA-2pxjA:
undetectable		 5mxbA-2pxjA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZ0_A_ZLDA301_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR)		 2pxj JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 3A
(Homo
sapiens) 		5 / 12 GLY A  80
ILE A 245
THR A  83
VAL A  75
LEU A 222
 None
 1.38A 5nz0A-2pxjA:
undetectable		 5nz0A-2pxjA:
20.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5PHH_A_LDPA414_1
(LYSINE-SPECIFIC
DEMETHYLASE 4D)		 2pxj JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 3A
(Homo
sapiens) 		4 / 6 GLU A 220
ALA A 236
LEU A 238
TYR A 275
 None
 0.24A 5phhA-2pxjA:
44.8		 5phhA-2pxjA:
62.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA204_0
(N-ACETYLTRANSFERASE)		 2pxj JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 3A
(Homo
sapiens) 		4 / 5 LEU A 125
THR A 126
THR A  83
GLY A  77
 None
 1.28A 6gtqA-2pxjA:
undetectable		 6gtqA-2pxjA:
19.13