SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pxs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_C_NIOC225_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2pxs GFP-LIKE FLUORESCENT
CHROMOPROTEIN FP506
(Zoanthus
sp.) 		4 / 6 THR A   9
PHE A  72
GLU A  11
GLY A  35
 None
 1.15A 1icuC-2pxsA:
undetectable
1icuD-2pxsA:
undetectable		 1icuC-2pxsA:
22.31
1icuD-2pxsA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_A_RBFA100_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 2pxs GFP-LIKE FLUORESCENT
CHROMOPROTEIN FP506
(Zoanthus
sp.) 		5 / 11 SER A   4
CYH A  87
LEU A   8
THR A   9
ILE A 111
 None
 1.07A 1pkvA-2pxsA:
undetectable
1pkvB-2pxsA:
undetectable		 1pkvA-2pxsA:
19.82
1pkvB-2pxsA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_B_RBFB101_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 2pxs GFP-LIKE FLUORESCENT
CHROMOPROTEIN FP506
(Zoanthus
sp.) 		5 / 11 SER A   4
CYH A  87
LEU A   8
THR A   9
ILE A 111
 None
 1.07A 1pkvA-2pxsA:
undetectable
1pkvB-2pxsA:
undetectable		 1pkvA-2pxsA:
19.82
1pkvB-2pxsA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_B_URFB999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 2pxs GFP-LIKE FLUORESCENT
CHROMOPROTEIN FP506
(Zoanthus
sp.) 		4 / 7 ALA A 223
TYR A  75
ILE A 224
PHE A 199
 None
 0.92A 1upfB-2pxsA:
undetectable		 1upfB-2pxsA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OD9_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 2pxs GFP-LIKE FLUORESCENT
CHROMOPROTEIN FP506
(Zoanthus
sp.) 		3 / 3 PHE A 126
PHE A  97
PHE A  99
 None
 0.48A 2od9A-2pxsA:
undetectable		 2od9A-2pxsA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QJU_A_DSMA801_1
(TRANSPORTER)		 2pxs GFP-LIKE FLUORESCENT
CHROMOPROTEIN FP506
(Zoanthus
sp.) 		5 / 11 LEU A 169
ILE A  60
PHE A 181
ALA A 103
PHE A 131
 None
 1.14A 2qjuA-2pxsA:
undetectable		 2qjuA-2pxsA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQG_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 2pxs GFP-LIKE FLUORESCENT
CHROMOPROTEIN FP506
(Zoanthus
sp.) 		3 / 3 PHE A 126
PHE A  97
PHE A  99
 None
 0.48A 2qqgA-2pxsA:
undetectable		 2qqgA-2pxsA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 2pxs GFP-LIKE FLUORESCENT
CHROMOPROTEIN FP506
(Zoanthus
sp.) 		4 / 8 LYS A  69
HIS A 122
ARG A  95
ALA A  63
 DYG  A  66 ( 3.5A)
XYG  A  66 ( 3.8A)
XYG  A  66 ( 2.7A)
DYG  A  66 ( 3.8A)
 1.33A 2rk8A-2pxsA:
undetectable		 2rk8A-2pxsA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1498_1
(CYTOCHROME P450 3A4)		 2pxs GFP-LIKE FLUORESCENT
CHROMOPROTEIN FP506
(Zoanthus
sp.) 		5 / 9 ILE A  60
ALA A  57
GLU A 146
GLY A 175
LEU A 171
 None
 1.23A 2v0mB-2pxsA:
undetectable		 2v0mB-2pxsA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		 2pxs GFP-LIKE FLUORESCENT
CHROMOPROTEIN FP506
(Zoanthus
sp.) 		3 / 3 HIS A 222
GLU A 221
HIS A 202
 None
DYG  A  66 ( 3.5A)
DYG  A  66 ( 3.2A)
 0.82A 3ba0A-2pxsA:
undetectable		 3ba0A-2pxsA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 2pxs GFP-LIKE FLUORESCENT
CHROMOPROTEIN FP506
(Zoanthus
sp.) 		4 / 5 PHE A 181
ILE A 160
LEU A 161
LYS A 162
 None
 1.15A 3sueC-2pxsA:
undetectable		 3sueC-2pxsA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 2pxs GFP-LIKE FLUORESCENT
CHROMOPROTEIN FP506
(Zoanthus
sp.) 		3 / 3 TYR A 168
MET A 167
ILE A 200
 None
XYG  A  66 ( 3.1A)
None
 0.66A 4c8bB-2pxsA:
undetectable		 4c8bB-2pxsA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA506_0
(RNA POLYMERASE
3D-POL)		 2pxs GFP-LIKE FLUORESCENT
CHROMOPROTEIN FP506
(Zoanthus
sp.) 		3 / 3 VAL A  28
GLY A  20
LYS A  26
 None
 0.69A 4k50A-2pxsA:
undetectable		 4k50A-2pxsA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE504_0
(RNA POLYMERASE
3D-POL)		 2pxs GFP-LIKE FLUORESCENT
CHROMOPROTEIN FP506
(Zoanthus
sp.) 		3 / 3 VAL A  28
GLY A  20
LYS A  26
 None
 0.73A 4k50E-2pxsA:
undetectable		 4k50E-2pxsA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI504_0
(RNA POLYMERASE
3D-POL)		 2pxs GFP-LIKE FLUORESCENT
CHROMOPROTEIN FP506
(Zoanthus
sp.) 		3 / 3 VAL A  28
GLY A  20
LYS A  26
 None
 0.72A 4k50I-2pxsA:
undetectable		 4k50I-2pxsA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 2pxs GFP-LIKE FLUORESCENT
CHROMOPROTEIN FP506
(Zoanthus
sp.) 		3 / 3 PRO A 195
MET A 194
TYR A  82
 None
 0.82A 4qa0B-2pxsA:
undetectable		 4qa0B-2pxsA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 2pxs GFP-LIKE FLUORESCENT
CHROMOPROTEIN FP506
(Zoanthus
sp.) 		3 / 3 PRO A 195
MET A 194
TYR A  82
 None
 0.82A 4qa0A-2pxsA:
undetectable		 4qa0A-2pxsA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 2pxs GFP-LIKE FLUORESCENT
CHROMOPROTEIN FP506
(Zoanthus
sp.) 		3 / 3 PRO A 195
MET A 194
TYR A  82
 None
 0.90A 4qa2B-2pxsA:
undetectable		 4qa2B-2pxsA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2S_A_ACTA107_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 2pxs GFP-LIKE FLUORESCENT
CHROMOPROTEIN FP506
(Zoanthus
sp.) 		3 / 3 VAL A  28
THR A  30
ARG A  17
 None
 0.77A 5b2sB-2pxsA:
undetectable		 5b2sB-2pxsA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2T_A_ACTA108_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 2pxs GFP-LIKE FLUORESCENT
CHROMOPROTEIN FP506
(Zoanthus
sp.) 		3 / 3 VAL A  28
THR A  30
ARG A  17
 None
 0.75A 5b2tB-2pxsA:
undetectable		 5b2tB-2pxsA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_F_SAMF301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2pxs GFP-LIKE FLUORESCENT
CHROMOPROTEIN FP506
(Zoanthus
sp.) 		5 / 12 ALA A  63
ASP A 182
PHE A 181
GLY A 163
GLU A 150
 DYG  A  66 ( 3.8A)
None
None
None
DYG  A  66 ( 4.6A)
 1.29A 5hfjF-2pxsA:
undetectable		 5hfjF-2pxsA:
19.60