SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pxx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA141_0
(LYSOZYME C)		 2pxx UNCHARACTERIZED
PROTEIN MGC2408
(Homo
sapiens) 		4 / 6 ASP A 134
GLY A 131
THR A 175
SER A 173
 None
SAH  A 301 (-4.1A)
None
None
 0.93A 1n4fA-2pxxA:
undetectable		 1n4fA-2pxxA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_F_REAF177_1
(RETINOL BINDING
PROTEIN)		 2pxx UNCHARACTERIZED
PROTEIN MGC2408
(Homo
sapiens) 		5 / 11 LEU A 158
ALA A 177
VAL A 161
LEU A 117
LEU A  65
 None
 1.17A 1rlbF-2pxxA:
undetectable		 1rlbF-2pxxA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_B_BEZB1503_0
(RAS-RELATED PROTEIN
RAB-9A)		 2pxx UNCHARACTERIZED
PROTEIN MGC2408
(Homo
sapiens) 		4 / 6 VAL A 154
THR A 153
GLU A 149
LEU A 137
 None
 1.13A 1s8fB-2pxxA:
undetectable		 1s8fB-2pxxA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2002_1
(SERUM ALBUMIN)		 2pxx UNCHARACTERIZED
PROTEIN MGC2408
(Homo
sapiens) 		5 / 10 PHE A 124
LEU A  52
LEU A 128
LEU A  63
VAL A  64
 None
 1.19A 2bxeA-2pxxA:
undetectable		 2bxeA-2pxxA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 2pxx UNCHARACTERIZED
PROTEIN MGC2408
(Homo
sapiens) 		4 / 7 TYR A  39
GLY A  68
ASP A  88
ASP A 113
 None
SAH  A 301 ( 3.2A)
SAH  A 301 (-2.9A)
SAH  A 301 (-3.1A)
 1.05A 2g72B-2pxxA:
13.6		 2g72B-2pxxA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 2pxx UNCHARACTERIZED
PROTEIN MGC2408
(Homo
sapiens) 		5 / 12 GLY A  66
GLY A  68
ASP A 113
VAL A 114
GLY A 131
 SAH  A 301 (-3.8A)
SAH  A 301 ( 3.2A)
SAH  A 301 (-3.1A)
SAH  A 301 (-3.6A)
SAH  A 301 (-4.1A)
 0.35A 2qe6A-2pxxA:
11.0		 2qe6A-2pxxA:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 2pxx UNCHARACTERIZED
PROTEIN MGC2408
(Homo
sapiens) 		5 / 12 GLY A  66
GLY A  68
ASP A 113
VAL A 114
GLY A 131
 SAH  A 301 (-3.8A)
SAH  A 301 ( 3.2A)
SAH  A 301 (-3.1A)
SAH  A 301 (-3.6A)
SAH  A 301 (-4.1A)
 0.37A 2qe6B-2pxxA:
11.0		 2qe6B-2pxxA:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_B_T44B128_1
(TRANSTHYRETIN)		 2pxx UNCHARACTERIZED
PROTEIN MGC2408
(Homo
sapiens) 		4 / 6 GLU A  22
ALA A 135
LEU A 137
THR A 132
 None
SAH  A 301 ( 3.7A)
None
SAH  A 301 ( 3.5A)
 1.02A 2roxB-2pxxA:
undetectable		 2roxB-2pxxA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA606_1
(CHITINASE A)		 2pxx UNCHARACTERIZED
PROTEIN MGC2408
(Homo
sapiens) 		4 / 7 TRP A  41
GLY A 139
LYS A  17
ASP A 134
 SAH  A 301 (-3.9A)
None
None
None
 0.98A 3arrA-2pxxA:
undetectable		 3arrA-2pxxA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA1_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 2pxx UNCHARACTERIZED
PROTEIN MGC2408
(Homo
sapiens) 		3 / 3 GLY A  68
ASP A  88
SER A  90
 SAH  A 301 ( 3.2A)
SAH  A 301 (-2.9A)
None
 0.62A 3brfA-2pxxA:
undetectable		 3brfA-2pxxA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2pxx UNCHARACTERIZED
PROTEIN MGC2408
(Homo
sapiens) 		3 / 3 GLY A  68
ASP A  88
ASP A 113
 SAH  A 301 ( 3.2A)
SAH  A 301 (-2.9A)
SAH  A 301 (-3.1A)
 0.40A 3ou7C-2pxxA:
16.2		 3ou7C-2pxxA:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_B_SAMB801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 2pxx UNCHARACTERIZED
PROTEIN MGC2408
(Homo
sapiens) 		5 / 11 GLY A  68
ASP A  88
ASP A 113
VAL A 114
LEU A 136
 SAH  A 301 ( 3.2A)
SAH  A 301 (-2.9A)
SAH  A 301 (-3.1A)
SAH  A 301 (-3.6A)
None
 0.96A 3v8vB-2pxxA:
11.5		 3v8vB-2pxxA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_1
(METHYLTRANSFERASE
NSUN4)		 2pxx UNCHARACTERIZED
PROTEIN MGC2408
(Homo
sapiens) 		3 / 3 ASP A 113
ARG A 115
ASP A  88
 SAH  A 301 (-3.1A)
None
SAH  A 301 (-2.9A)
 0.62A 4fp9A-2pxxA:
10.3		 4fp9A-2pxxA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_A_SAMA401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 2pxx UNCHARACTERIZED
PROTEIN MGC2408
(Homo
sapiens) 		5 / 11 GLY A  66
ASP A  88
VAL A  93
ASP A 113
LYS A 130
 SAH  A 301 (-3.8A)
SAH  A 301 (-2.9A)
None
SAH  A 301 (-3.1A)
SAH  A 301 (-2.6A)
 1.03A 4pghA-2pxxA:
14.2		 4pghA-2pxxA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_C_SAMC401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 2pxx UNCHARACTERIZED
PROTEIN MGC2408
(Homo
sapiens) 		5 / 11 GLY A  66
ASP A  88
VAL A  93
ASP A 113
LYS A 130
 SAH  A 301 (-3.8A)
SAH  A 301 (-2.9A)
None
SAH  A 301 (-3.1A)
SAH  A 301 (-2.6A)
 1.08A 4pghC-2pxxA:
15.3		 4pghC-2pxxA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_C_PARC500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 2pxx UNCHARACTERIZED
PROTEIN MGC2408
(Homo
sapiens) 		5 / 10 SER A 176
PHE A 206
SER A 173
TYR A 186
TYR A  20
 None
 1.32A 4qb9C-2pxxA:
1.0		 4qb9C-2pxxA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_E_PARE500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 2pxx UNCHARACTERIZED
PROTEIN MGC2408
(Homo
sapiens) 		5 / 12 SER A 176
PHE A 206
SER A 173
TYR A 186
TYR A  20
 None
 1.43A 4qb9E-2pxxA:
undetectable		 4qb9E-2pxxA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_1
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 2pxx UNCHARACTERIZED
PROTEIN MGC2408
(Homo
sapiens) 		3 / 3 SER A 173
TYR A 186
ASP A 134
 None
 0.82A 4rp8C-2pxxA:
undetectable		 4rp8C-2pxxA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZ8_A_GCSA208_1
(GLUCANASE/CHITOSANAS
E)		 2pxx UNCHARACTERIZED
PROTEIN MGC2408
(Homo
sapiens) 		4 / 7 TYR A  25
ASP A 134
ALA A 135
TYR A  20
 None
None
SAH  A 301 ( 3.7A)
None
 0.85A 4zz8A-2pxxA:
undetectable		 4zz8A-2pxxA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 2pxx UNCHARACTERIZED
PROTEIN MGC2408
(Homo
sapiens) 		5 / 12 GLY A  66
GLY A  68
LEU A  72
VAL A 114
ALA A 135
 SAH  A 301 (-3.8A)
SAH  A 301 ( 3.2A)
None
SAH  A 301 (-3.6A)
SAH  A 301 ( 3.7A)
 0.75A 5kpcA-2pxxA:
12.6		 5kpcA-2pxxA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 2pxx UNCHARACTERIZED
PROTEIN MGC2408
(Homo
sapiens) 		5 / 12 GLY A  66
GLY A  68
SER A  70
LEU A  72
VAL A 114
 SAH  A 301 (-3.8A)
SAH  A 301 ( 3.2A)
SAH  A 301 ( 3.9A)
None
SAH  A 301 (-3.6A)
 0.95A 5kpcA-2pxxA:
12.6		 5kpcA-2pxxA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 2pxx UNCHARACTERIZED
PROTEIN MGC2408
(Homo
sapiens) 		4 / 5 LEU A  72
LEU A  76
MET A  97
TYR A  39
 None
None
UNX  A 300 (-3.5A)
None
 1.35A 5uc3A-2pxxA:
undetectable		 5uc3A-2pxxA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WY0_A_SAMA800_0
(SMALL RNA
2'-O-METHYLTRANSFERA
SE)		 2pxx UNCHARACTERIZED
PROTEIN MGC2408
(Homo
sapiens) 		5 / 12 GLY A  66
GLY A  68
ASP A  88
VAL A 114
LEU A 136
 SAH  A 301 (-3.8A)
SAH  A 301 ( 3.2A)
SAH  A 301 (-2.9A)
SAH  A 301 (-3.6A)
None
 0.44A 5wy0A-2pxxA:
13.3		 5wy0A-2pxxA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)		 2pxx UNCHARACTERIZED
PROTEIN MGC2408
(Homo
sapiens) 		6 / 11 GLY A  66
GLY A  68
ASP A  88
VAL A  93
ASP A 113
LYS A 130
 SAH  A 301 (-3.8A)
SAH  A 301 ( 3.2A)
SAH  A 301 (-2.9A)
None
SAH  A 301 (-3.1A)
SAH  A 301 (-2.6A)
 1.16A 6i5zD-2pxxA:
13.4		 6i5zD-2pxxA:
20.89