SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2py6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 2py6 METHYLTRANSFERASE
FKBM
(Methylobacillus
flagellatus) 		5 / 12 ASP A 377
LEU A 376
ILE A 166
LEU A 193
TYR A 157
 None
 1.22A 1ddrB-2py6A:
undetectable		 1ddrB-2py6A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRE_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2py6 METHYLTRANSFERASE
FKBM
(Methylobacillus
flagellatus) 		5 / 12 ASP A 377
LEU A 376
ILE A 166
LEU A 193
TYR A 157
 None
 1.15A 1dreA-2py6A:
undetectable		 1dreA-2py6A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOM_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 2py6 METHYLTRANSFERASE
FKBM
(Methylobacillus
flagellatus) 		5 / 11 ASP A 377
LEU A 376
ILE A 166
LEU A 193
TYR A 157
 None
 1.28A 1jomA-2py6A:
undetectable		 1jomA-2py6A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		 2py6 METHYLTRANSFERASE
FKBM
(Methylobacillus
flagellatus) 		5 / 12 ASP A 328
ILE A 357
ASP A 388
ILE A 382
TYR A 381
 None
 1.29A 1kijB-2py6A:
undetectable		 1kijB-2py6A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RE7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2py6 METHYLTRANSFERASE
FKBM
(Methylobacillus
flagellatus) 		5 / 12 ILE A 385
ALA A 356
ASP A 328
ILE A 366
ILE A 382
 None
 1.12A 1re7A-2py6A:
undetectable		 1re7A-2py6A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2py6 METHYLTRANSFERASE
FKBM
(Methylobacillus
flagellatus) 		5 / 12 ASP A 377
LEU A 376
ILE A 166
LEU A 193
TYR A 157
 None
 1.14A 1rh3A-2py6A:
undetectable		 1rh3A-2py6A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RK3_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 2py6 METHYLTRANSFERASE
FKBM
(Methylobacillus
flagellatus) 		4 / 4 LEU A 116
ILE A  98
ARG A 102
TYR A  92
 None
 1.43A 1rk3A-2py6A:
undetectable		 1rk3A-2py6A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_A_MTXA170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 2py6 METHYLTRANSFERASE
FKBM
(Methylobacillus
flagellatus) 		5 / 12 ASP A 377
LEU A 376
ILE A 166
LEU A 193
TYR A 157
 None
 1.16A 1tdrA-2py6A:
undetectable		 1tdrA-2py6A:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_B_MTXB170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 2py6 METHYLTRANSFERASE
FKBM
(Methylobacillus
flagellatus) 		5 / 10 ASP A 377
LEU A 376
ILE A 166
LEU A 193
TYR A 157
 None
 1.18A 1tdrB-2py6A:
2.7		 1tdrB-2py6A:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 2py6 METHYLTRANSFERASE
FKBM
(Methylobacillus
flagellatus) 		4 / 6 ARG A 400
GLY A 163
ALA A 164
HIS A 196
 EDO  A 410 (-3.7A)
None
None
EDO  A 410 (-3.5A)
 0.99A 1wrqA-2py6A:
undetectable		 1wrqA-2py6A:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 2py6 METHYLTRANSFERASE
FKBM
(Methylobacillus
flagellatus) 		4 / 6 ARG A 400
GLY A 163
ALA A 164
HIS A 196
 EDO  A 410 (-3.7A)
None
None
EDO  A 410 (-3.5A)
 1.00A 1wrqB-2py6A:
undetectable		 1wrqB-2py6A:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A7Q_A_CFBA328_2
(DEOXYCYTIDINE KINASE)		 2py6 METHYLTRANSFERASE
FKBM
(Methylobacillus
flagellatus) 		4 / 4 ILE A 166
ASP A 374
LEU A 176
ARG A 168
 None
None
None
EDO  A 413 (-3.8A)
 1.35A 2a7qA-2py6A:
undetectable		 2a7qA-2py6A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 2py6 METHYLTRANSFERASE
FKBM
(Methylobacillus
flagellatus) 		3 / 3 GLY A 233
GLU A 258
ASP A 341
 UNL  A 414 (-4.0A)
None
None
 0.37A 2b25B-2py6A:
9.6		 2b25B-2py6A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_A_BRLA1_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2py6 METHYLTRANSFERASE
FKBM
(Methylobacillus
flagellatus) 		3 / 3 ILE A 342
ILE A 366
LEU A 267
 UNL  A 414 (-3.1A)
None
None
 0.52A 2prgA-2py6A:
undetectable		 2prgA-2py6A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W1B_A_DXCA2034_0
(ACRIFLAVIN
RESISTANCE PROTEIN B)		 2py6 METHYLTRANSFERASE
FKBM
(Methylobacillus
flagellatus) 		3 / 3 PHE A 337
SER A 218
LEU A 214
 None
 0.71A 2w1bA-2py6A:
undetectable		 2w1bA-2py6A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 2py6 METHYLTRANSFERASE
FKBM
(Methylobacillus
flagellatus) 		5 / 10 VAL A 254
PHE A 337
SER A 224
VAL A 246
GLY A 245
 None
 1.44A 2x2iD-2py6A:
undetectable		 2x2iD-2py6A:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 2py6 METHYLTRANSFERASE
FKBM
(Methylobacillus
flagellatus) 		4 / 5 LEU A 116
ILE A  98
ARG A 102
TYR A  92
 None
 1.44A 2zlcA-2py6A:
undetectable		 2zlcA-2py6A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A7E_A_SAMA216_1
(CATECHOL
O-METHYLTRANSFERASE)		 2py6 METHYLTRANSFERASE
FKBM
(Methylobacillus
flagellatus) 		4 / 6 GLY A 233
ILE A 257
GLU A 258
ASP A 341
 UNL  A 414 (-4.0A)
UNL  A 414 (-4.3A)
None
None
 0.41A 3a7eA-2py6A:
10.9		 3a7eA-2py6A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A7E_A_SAMA216_1
(CATECHOL
O-METHYLTRANSFERASE)		 2py6 METHYLTRANSFERASE
FKBM
(Methylobacillus
flagellatus) 		4 / 6 GLY A 233
SER A 239
ILE A 257
GLU A 258
 UNL  A 414 (-4.0A)
None
UNL  A 414 (-4.3A)
None
 0.51A 3a7eA-2py6A:
10.9		 3a7eA-2py6A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2py6 METHYLTRANSFERASE
FKBM
(Methylobacillus
flagellatus) 		5 / 10 ILE A 327
GLY A 352
LEU A 378
ILE A 357
MET A 340
 None
 1.21A 3adsA-2py6A:
undetectable		 3adsA-2py6A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2py6 METHYLTRANSFERASE
FKBM
(Methylobacillus
flagellatus) 		5 / 11 GLY A 233
GLU A 258
ALA A 290
ASP A 341
ILE A 342
 UNL  A 414 (-4.0A)
None
UNL  A 414 (-3.9A)
None
UNL  A 414 (-3.1A)
 0.49A 3id5B-2py6A:
5.3		 3id5B-2py6A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_F_SAMF301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2py6 METHYLTRANSFERASE
FKBM
(Methylobacillus
flagellatus) 		5 / 11 GLY A 233
GLU A 258
ALA A 290
ASP A 341
ILE A 342
 UNL  A 414 (-4.0A)
None
UNL  A 414 (-3.9A)
None
UNL  A 414 (-3.1A)
 0.49A 3id5F-2py6A:
10.3		 3id5F-2py6A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID6_C_SAMC301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2py6 METHYLTRANSFERASE
FKBM
(Methylobacillus
flagellatus) 		5 / 12 GLY A 233
GLU A 258
ALA A 290
ASP A 341
ILE A 342
 UNL  A 414 (-4.0A)
None
UNL  A 414 (-3.9A)
None
UNL  A 414 (-3.1A)
 0.65A 3id6C-2py6A:
4.4		 3id6C-2py6A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 2py6 METHYLTRANSFERASE
FKBM
(Methylobacillus
flagellatus) 		5 / 11 GLY A 233
ILE A 257
GLU A 258
ALA A 290
ASP A 341
 UNL  A 414 (-4.0A)
UNL  A 414 (-4.3A)
None
UNL  A 414 (-3.9A)
None
 0.46A 3nmuB-2py6A:
undetectable
3nmuJ-2py6A:
9.9		 3nmuB-2py6A:
20.81
3nmuJ-2py6A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_A_RBFA190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 2py6 METHYLTRANSFERASE
FKBM
(Methylobacillus
flagellatus) 		5 / 12 LEU A 189
THR A 188
ASP A 182
GLY A 392
ALA A 368
 None
 1.13A 3p5nA-2py6A:
undetectable		 3p5nA-2py6A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_B_RBFB190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 2py6 METHYLTRANSFERASE
FKBM
(Methylobacillus
flagellatus) 		5 / 12 LEU A 189
THR A 188
ASP A 182
GLY A 392
ALA A 368
 None
 1.13A 3p5nB-2py6A:
undetectable		 3p5nB-2py6A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL3_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2py6 METHYLTRANSFERASE
FKBM
(Methylobacillus
flagellatus) 		5 / 12 ILE A 385
ALA A 356
ASP A 328
ILE A 366
ILE A 382
 None
 1.05A 3ql3A-2py6A:
undetectable		 3ql3A-2py6A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		 2py6 METHYLTRANSFERASE
FKBM
(Methylobacillus
flagellatus) 		5 / 11 ILE A  98
PHE A 128
THR A 118
PRO A  96
VAL A  55
 None
 1.00A 3tmzA-2py6A:
undetectable		 3tmzA-2py6A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2py6 METHYLTRANSFERASE
FKBM
(Methylobacillus
flagellatus) 		5 / 11 SER A 239
ILE A 236
VAL A 270
LEU A 267
VAL A 285
 None
None
PEG  A 415 (-4.5A)
None
None
 0.96A 3w67A-2py6A:
0.2		 3w67A-2py6A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2py6 METHYLTRANSFERASE
FKBM
(Methylobacillus
flagellatus) 		5 / 12 TYR A 215
ILE A 236
VAL A 270
LEU A 267
VAL A 285
 None
None
PEG  A 415 (-4.5A)
None
None
 1.03A 3w68A-2py6A:
undetectable		 3w68A-2py6A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_B_ACTB201_0
(RETINOL-BINDING
PROTEIN 2)		 2py6 METHYLTRANSFERASE
FKBM
(Methylobacillus
flagellatus) 		4 / 5 TYR A 369
TYR A 211
GLU A 238
LEU A 214
 None
None
PEG  A 415 (-4.7A)
None
 1.35A 4qztB-2py6A:
undetectable		 4qztB-2py6A:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_2
(TUBULIN BETA-2B
CHAIN)		 2py6 METHYLTRANSFERASE
FKBM
(Methylobacillus
flagellatus) 		3 / 3 LEU A 393
LEU A 176
ARG A 386
 None
 0.61A 5hnzB-2py6A:
1.3		 5hnzB-2py6A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_I_IPHI101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 2py6 METHYLTRANSFERASE
FKBM
(Methylobacillus
flagellatus) 		4 / 6 VAL A 192
HIS A 196
LEU A 193
LEU A 375
 None
EDO  A 410 (-3.5A)
None
None
 1.15A 5hrqB-2py6A:
undetectable
5hrqI-2py6A:
undetectable
5hrqJ-2py6A:
undetectable		 5hrqB-2py6A:
5.94
5hrqI-2py6A:
3.42
5hrqJ-2py6A:
5.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2py6 METHYLTRANSFERASE
FKBM
(Methylobacillus
flagellatus) 		4 / 7 ILE A 170
PHE A  22
THR A 373
LEU A 376
 None
 0.94A 5iy5N-2py6A:
undetectable
5iy5W-2py6A:
undetectable		 5iy5N-2py6A:
20.60
5iy5W-2py6A:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8H_B_478B401_2
(PROTEASE)		 2py6 METHYLTRANSFERASE
FKBM
(Methylobacillus
flagellatus) 		5 / 12 LEU A 264
GLY A 233
ALA A 234
VAL A 254
ILE A 330
 None
UNL  A 414 (-4.0A)
None
None
None
 0.89A 5t8hB-2py6A:
undetectable		 5t8hB-2py6A:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_1
(MRNA CAPPING ENZYME
P5)		 2py6 METHYLTRANSFERASE
FKBM
(Methylobacillus
flagellatus) 		3 / 3 TYR A 215
ASP A 231
ASP A 341
 None
 0.86A 5x6yA-2py6A:
6.0		 5x6yA-2py6A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2py6 METHYLTRANSFERASE
FKBM
(Methylobacillus
flagellatus) 		3 / 3 TYR A 406
ARG A 394
THR A 213
 None
 0.87A 5z84J-2py6A:
undetectable		 5z84J-2py6A:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2py6 METHYLTRANSFERASE
FKBM
(Methylobacillus
flagellatus) 		4 / 5 TYR A 406
ARG A 394
THR A 213
LEU A 214
 None
 1.29A 5z86J-2py6A:
undetectable		 5z86J-2py6A:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_A_9KLA402_0
(EST-Y29)		 2py6 METHYLTRANSFERASE
FKBM
(Methylobacillus
flagellatus) 		5 / 12 TYR A 381
ILE A 357
LEU A 364
GLY A 291
ALA A 349
 None
 1.24A 5zwrA-2py6A:
undetectable		 5zwrA-2py6A:
23.25