SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pyb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 2pyb NEUTROPHIL
ACTIVATING PROTEIN
(Borreliella
burgdorferi) 		5 / 7 ARG A  72
LEU A  24
LEU A 146
MET A 143
ILE A 127
 None
 1.38A 3gp0A-2pybA:
undetectable		 3gp0A-2pybA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1480_0
(MJ0495-LIKE PROTEIN)		 2pyb NEUTROPHIL
ACTIVATING PROTEIN
(Borreliella
burgdorferi) 		4 / 4 LYS A  88
GLU A  93
ILE A  29
SER A  26
 None
 1.34A 4ac9C-2pybA:
undetectable		 4ac9C-2pybA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1480_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2pyb NEUTROPHIL
ACTIVATING PROTEIN
(Borreliella
burgdorferi) 		4 / 4 LYS A  88
GLU A  93
ILE A  29
SER A  26
 None
 1.30A 4acaC-2pybA:
undetectable		 4acaC-2pybA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1480_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2pyb NEUTROPHIL
ACTIVATING PROTEIN
(Borreliella
burgdorferi) 		4 / 4 LYS A  88
GLU A  93
ILE A  29
SER A  26
 None
 1.34A 4acbC-2pybA:
undetectable		 4acbC-2pybA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_1
(METHYLTRANSFERASE
NSUN4)		 2pyb NEUTROPHIL
ACTIVATING PROTEIN
(Borreliella
burgdorferi) 		3 / 3 ASP A 132
ARG A  70
ASP A 128
 None
 0.82A 4fp9A-2pybA:
undetectable		 4fp9A-2pybA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_1
(METHYLTRANSFERASE
NSUN4)		 2pyb NEUTROPHIL
ACTIVATING PROTEIN
(Borreliella
burgdorferi) 		3 / 3 ASP A 132
ARG A  70
ASP A 128
 None
 0.86A 4fp9C-2pybA:
undetectable		 4fp9C-2pybA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_1
(METHYLTRANSFERASE
NSUN4)		 2pyb NEUTROPHIL
ACTIVATING PROTEIN
(Borreliella
burgdorferi) 		3 / 3 ASP A 132
ARG A  70
ASP A 128
 None
 0.83A 4fp9F-2pybA:
undetectable		 4fp9F-2pybA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKW_A_TESA601_1
(AROMATASE)		 2pyb NEUTROPHIL
ACTIVATING PROTEIN
(Borreliella
burgdorferi) 		5 / 11 PHE A  30
ILE A 142
ASP A 145
VAL A 110
LEU A  56
 None
 1.14A 5jkwA-2pybA:
undetectable		 5jkwA-2pybA:
14.66