SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pyh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHO_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2pyh POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 4
(Azotobacter
vinelandii) 		5 / 9 GLY A 242
GLY A 221
PHE A 198
LEU A 222
GLY A 251
 None
 1.25A 1jhoA-2pyhA:
undetectable		 1jhoA-2pyhA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHQ_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2pyh POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 4
(Azotobacter
vinelandii) 		5 / 8 GLY A 242
GLY A 221
PHE A 198
LEU A 222
GLY A 251
 None
 1.26A 1jhqA-2pyhA:
undetectable		 1jhqA-2pyhA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHR_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2pyh POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 4
(Azotobacter
vinelandii) 		5 / 9 GLY A 242
GLY A 221
PHE A 198
LEU A 222
GLY A 251
 None
 1.27A 1jhrA-2pyhA:
undetectable		 1jhrA-2pyhA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L4N_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2pyh POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 4
(Azotobacter
vinelandii) 		5 / 9 GLY A 242
GLY A 221
PHE A 198
LEU A 222
GLY A 251
 None
 1.24A 1l4nA-2pyhA:
undetectable		 1l4nA-2pyhA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5K_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2pyh POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 4
(Azotobacter
vinelandii) 		5 / 9 GLY A 242
GLY A 221
PHE A 198
LEU A 222
GLY A 251
 None
 1.23A 1l5kA-2pyhA:
undetectable		 1l5kA-2pyhA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5L_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2pyh POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 4
(Azotobacter
vinelandii) 		5 / 9 GLY A 242
GLY A 221
PHE A 198
LEU A 222
GLY A 251
 None
 1.27A 1l5lA-2pyhA:
undetectable		 1l5lA-2pyhA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5M_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2pyh POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 4
(Azotobacter
vinelandii) 		5 / 9 GLY A 242
GLY A 221
PHE A 198
LEU A 222
GLY A 251
 None
 1.26A 1l5mA-2pyhA:
undetectable		 1l5mA-2pyhA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_1
(POL POLYPROTEIN)		 2pyh POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 4
(Azotobacter
vinelandii) 		5 / 8 ASP A  13
ASP A  17
ILE A  22
GLY A   9
PRO A  40
 None
 1.50A 1sh9A-2pyhA:
undetectable		 1sh9A-2pyhA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O5Y_H_STRH249_1
(CHIMERIC ANTIBODY
FAB 1E9-DB3)		 2pyh POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 4
(Azotobacter
vinelandii) 		4 / 7 GLY A 101
THR A 137
MET A 102
SER A 165
 None
 1.27A 2o5yH-2pyhA:
undetectable
2o5yL-2pyhA:
undetectable		 2o5yH-2pyhA:
21.97
2o5yL-2pyhA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBZ_A_VDXA501_1
(CYTOCHROME P450-SU1)		 2pyh POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 4
(Azotobacter
vinelandii) 		5 / 11 LEU A 222
VAL A 252
MET A 209
ILE A 239
ALA A 280
 None
 1.13A 2zbzA-2pyhA:
undetectable		 2zbzA-2pyhA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC59_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2pyh POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 4
(Azotobacter
vinelandii) 		3 / 3 GLY A 174
GLY A 148
GLY A 150
 None
 0.35A 3bogC-2pyhA:
undetectable		 3bogC-2pyhA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_2
(PROTEASE)		 2pyh POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 4
(Azotobacter
vinelandii) 		5 / 10 GLY A 242
ALA A 265
ASP A 266
ILE A 290
GLY A 251
 None
 1.06A 3el9B-2pyhA:
undetectable		 3el9B-2pyhA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_2
(PROTEASE)		 2pyh POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 4
(Azotobacter
vinelandii) 		5 / 12 GLY A 279
ALA A 280
ILE A 260
VAL A 224
VAL A 283
 None
 0.78A 3ucbB-2pyhA:
undetectable		 3ucbB-2pyhA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_B_MIYB2001_1
(TETX2 PROTEIN)		 2pyh POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 4
(Azotobacter
vinelandii) 		4 / 8 PHE A 198
GLY A 197
GLY A 241
ASN A 187
 None
 0.99A 3v3nB-2pyhA:
undetectable		 3v3nB-2pyhA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_C_MIYC2001_1
(TETX2 PROTEIN)		 2pyh POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 4
(Azotobacter
vinelandii) 		4 / 8 PHE A 198
GLY A 197
GLY A 241
ASN A 187
 None
 0.98A 3v3nC-2pyhA:
undetectable		 3v3nC-2pyhA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD392_1
(TETX2 PROTEIN)		 2pyh POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 4
(Azotobacter
vinelandii) 		4 / 5 HIS A 291
SER A 331
SER A 333
VAL A 360
 None
 1.50A 4a99D-2pyhA:
undetectable		 4a99D-2pyhA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CCQ_A_ACTA1317_0
(THIOREDOXIN
REDUCTASE)		 2pyh POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 4
(Azotobacter
vinelandii) 		3 / 3 LEU A 352
GLU A 376
SER A 374
 None
 0.84A 4ccqA-2pyhA:
undetectable		 4ccqA-2pyhA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J83_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2pyh POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 4
(Azotobacter
vinelandii) 		5 / 11 ALA A 214
GLY A 150
ASN A 170
ASN A 217
HIS A 196
 None
 0.91A 4j83A-2pyhA:
undetectable		 4j83A-2pyhA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L64_A_C2FA802_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 2pyh POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 4
(Azotobacter
vinelandii) 		4 / 7 SER A 165
ARG A 140
VAL A 141
TRP A 121
 None
 1.35A 4l64A-2pyhA:
undetectable		 4l64A-2pyhA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLB_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 2pyh POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 4
(Azotobacter
vinelandii) 		3 / 3 VAL A 189
ALA A 167
PHE A 198
 None
 0.92A 4olbA-2pyhA:
undetectable		 4olbA-2pyhA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2pyh POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 4
(Azotobacter
vinelandii) 		5 / 9 ALA A  28
ALA A  25
GLY A  33
GLY A  34
ASP A   2
 None
 1.03A 4qwuY-2pyhA:
undetectable
4qwuZ-2pyhA:
undetectable		 4qwuY-2pyhA:
20.00
4qwuZ-2pyhA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2pyh POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 4
(Azotobacter
vinelandii) 		4 / 4 ASN A 288
VAL A 252
THR A 261
ILE A 260
 None
 1.50A 4retA-2pyhA:
undetectable		 4retA-2pyhA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2pyh POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 4
(Azotobacter
vinelandii) 		4 / 4 ASN A 288
VAL A 252
THR A 261
ILE A 260
 None
 1.49A 4retC-2pyhA:
undetectable		 4retC-2pyhA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_F_TR6F101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 2pyh POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 4
(Azotobacter
vinelandii) 		4 / 5 GLY A 148
ARG A 111
GLY A 109
GLU A 145
 None
None
None
CA  A 379 ( 4.5A)
 1.01A 4z2eB-2pyhA:
undetectable
4z2eC-2pyhA:
undetectable		 4z2eB-2pyhA:
23.64
4z2eC-2pyhA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 2pyh POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 4
(Azotobacter
vinelandii) 		3 / 3 VAL A 189
ALA A 167
PHE A 198
 None
 0.90A 4z4iA-2pyhA:
undetectable		 4z4iA-2pyhA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2pyh POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 4
(Azotobacter
vinelandii) 		5 / 12 GLY A  53
LEU A  77
LEU A  57
THR A  86
MET A  88
 None
 1.34A 4ze1A-2pyhA:
undetectable		 4ze1A-2pyhA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ENT_C_MIYC901_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB)		 2pyh POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 4
(Azotobacter
vinelandii) 		5 / 9 PHE A 198
GLY A 221
SER A 220
GLU A 250
ASN A 270
 None
 1.39A 5entC-2pyhA:
undetectable		 5entC-2pyhA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 2pyh POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 4
(Azotobacter
vinelandii) 		3 / 3 VAL A 189
ALA A 167
PHE A 198
 None
 0.91A 5js1A-2pyhA:
undetectable		 5js1A-2pyhA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUE_A_VIVA302_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2pyh POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 4
(Azotobacter
vinelandii) 		5 / 12 ILE A 267
VAL A 277
LEU A 254
VAL A 252
ILE A 239
 None
 0.98A 5mueA-2pyhA:
undetectable		 5mueA-2pyhA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2pyh POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 4
(Azotobacter
vinelandii) 		5 / 9 GLY A 109
LEU A  77
VAL A  46
ILE A  85
ILE A  26
 None
 0.89A 5vkqC-2pyhA:
undetectable
5vkqD-2pyhA:
undetectable		 5vkqC-2pyhA:
12.88
5vkqD-2pyhA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_A_DAHA60_1
(PUTATIVE CYTOCHROME
C)		 2pyh POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 4
(Azotobacter
vinelandii) 		4 / 6 MET A 102
ASN A  99
VAL A  63
LEU A  65
 None
 1.50A 5xdhA-2pyhA:
undetectable
5xdhC-2pyhA:
undetectable		 5xdhA-2pyhA:
11.73
5xdhC-2pyhA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_F_EY4F500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2pyh POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 4
(Azotobacter
vinelandii) 		4 / 7 ALA A 280
THR A 257
ILE A 285
VAL A 277
 None
 0.89A 6cduF-2pyhA:
undetectable
6cduJ-2pyhA:
undetectable		 6cduF-2pyhA:
21.09
6cduJ-2pyhA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_B_LLLB301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2pyh POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 4
(Azotobacter
vinelandii) 		4 / 7 ARG A 144
GLU A 145
ASP A 108
GLU A  43
 None
CA  A 379 ( 4.5A)
None
None
 1.30A 6mn5B-2pyhA:
undetectable		 6mn5B-2pyhA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_D_LLLD301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2pyh POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 4
(Azotobacter
vinelandii) 		4 / 6 ARG A 144
GLU A 145
ASP A 108
GLU A  43
 None
CA  A 379 ( 4.5A)
None
None
 1.33A 6mn5D-2pyhA:
undetectable		 6mn5D-2pyhA:
15.96