SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pyj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_A_ESTA600_1
(ESTROGEN RECEPTOR)		 2pyj DNA POLYMERASE
(Bacillus
virus
phi29) 		5 / 11 LEU A 185
ALA A 190
LEU A 384
ILE A 378
LEU A 126
 EDO  A2793 ( 4.8A)
None
None
None
None
 1.17A 1g50A-2pyjA:
undetectable		 1g50A-2pyjA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GM7_B_PNNB1577_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 2pyj DNA POLYMERASE
(Bacillus
virus
phi29) 		4 / 8 PHE A 181
ALA A 176
PHE A 137
ILE A 173
 None
 1.08A 1gm7A-2pyjA:
undetectable
1gm7B-2pyjA:
undetectable		 1gm7A-2pyjA:
16.67
1gm7B-2pyjA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_1
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 2pyj DNA POLYMERASE
(Bacillus
virus
phi29) 		4 / 7 LEU A 328
ILE A 299
THR A 301
GLN A 446
 None
 1.29A 1kglA-2pyjA:
undetectable		 1kglA-2pyjA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_A_ESTA1_1
(ESTROGEN RECEPTOR)		 2pyj DNA POLYMERASE
(Bacillus
virus
phi29) 		5 / 10 LEU A 185
ALA A 190
LEU A 384
ILE A 378
LEU A 126
 EDO  A2793 ( 4.8A)
None
None
None
None
 1.22A 1pcgA-2pyjA:
undetectable		 1pcgA-2pyjA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R5L_A_VIVA301_0
(PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN))		 2pyj DNA POLYMERASE
(Bacillus
virus
phi29) 		5 / 12 VAL A  54
PHE A  47
ILE A 105
ILE A 119
ILE A 103
 None
 1.36A 1r5lA-2pyjA:
undetectable		 1r5lA-2pyjA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		 2pyj DNA POLYMERASE
(Bacillus
virus
phi29) 		4 / 8 TRP A  81
GLY A  67
LEU A  74
PRO A 404
 None
 0.85A 1ya4A-2pyjA:
undetectable		 1ya4A-2pyjA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		 2pyj DNA POLYMERASE
(Bacillus
virus
phi29) 		4 / 7 TRP A  81
GLY A  67
LEU A  74
PRO A 404
 None
 0.88A 1ya4B-2pyjA:
undetectable		 1ya4B-2pyjA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_IMNA2003_1
(SERUM ALBUMIN)		 2pyj DNA POLYMERASE
(Bacillus
virus
phi29) 		5 / 10 LEU A 335
ILE A 442
TYR A 315
ARG A 227
GLY A 229
 None
 1.20A 2bxqA-2pyjA:
0.0		 2bxqA-2pyjA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_A_CHDA1_0
(LIVER
CARBOXYLESTERASE 1)		 2pyj DNA POLYMERASE
(Bacillus
virus
phi29) 		4 / 5 TRP A  81
GLY A  67
LEU A  74
PRO A 404
 None
 0.98A 2dqyA-2pyjA:
undetectable		 2dqyA-2pyjA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA502_1
(CYTOCHROME P450 2C8)		 2pyj DNA POLYMERASE
(Bacillus
virus
phi29) 		5 / 12 ILE A  71
ILE A 103
LEU A  74
ASN A  77
VAL A  51
 None
 1.01A 2nnhA-2pyjA:
undetectable		 2nnhA-2pyjA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB502_1
(CYTOCHROME P450 2C8)		 2pyj DNA POLYMERASE
(Bacillus
virus
phi29) 		5 / 10 ILE A  71
ILE A 103
LEU A  74
ASN A  77
VAL A  51
 None
 0.98A 2nnhB-2pyjA:
undetectable		 2nnhB-2pyjA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_A_CLUA808_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 2pyj DNA POLYMERASE
(Bacillus
virus
phi29) 		4 / 7 ALA A 394
TYR A 226
TYR A 390
MET A 258
 None
None
DGT  A1588 (-4.4A)
None
 1.47A 2pncA-2pyjA:
undetectable		 2pncA-2pyjA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YDO_A_ADNA400_1
(ADENOSINE RECEPTOR
A2A)		 2pyj DNA POLYMERASE
(Bacillus
virus
phi29) 		5 / 12 LEU A 381
PHE A 137
LEU A 177
ILE A 173
SER A 122
 None
 1.40A 2ydoA-2pyjA:
undetectable		 2ydoA-2pyjA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YDO_A_ADNA400_1
(ADENOSINE RECEPTOR
A2A)		 2pyj DNA POLYMERASE
(Bacillus
virus
phi29) 		5 / 12 PHE A 137
LEU A 177
ILE A 173
SER A 122
HIS A  61
 None
 1.28A 2ydoA-2pyjA:
undetectable		 2ydoA-2pyjA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		 2pyj DNA POLYMERASE
(Bacillus
virus
phi29) 		4 / 8 ILE A 442
TYR A 315
ARG A 227
GLY A 229
 None
 0.95A 3b9lA-2pyjA:
undetectable		 3b9lA-2pyjA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1200_1
(SERUM ALBUMIN)		 2pyj DNA POLYMERASE
(Bacillus
virus
phi29) 		4 / 5 ILE A 442
TYR A 315
ARG A 227
GLY A 229
 None
 1.17A 3b9mA-2pyjA:
undetectable		 3b9mA-2pyjA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KD5_E_PPFE914_1
(DNA POLYMERASE)		 2pyj DNA POLYMERASE
(Bacillus
virus
phi29) 		4 / 5 ASP A 249
LEU A 253
LYS A 383
ASP A 458
 MG  A9004 (-2.3A)
None
DGT  A1588 ( 2.7A)
MG  A9004 (-2.5A)
 0.62A 3kd5E-2pyjA:
9.9		 3kd5E-2pyjA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2pyj DNA POLYMERASE
(Bacillus
virus
phi29) 		4 / 8 LEU A  44
SER A  43
LEU A  58
PHE A  13
 None
 0.93A 3ln1A-2pyjA:
undetectable		 3ln1A-2pyjA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2pyj DNA POLYMERASE
(Bacillus
virus
phi29) 		4 / 8 LEU A 389
SER A 388
LEU A 263
PHE A 393
 None
 0.94A 3ln1A-2pyjA:
undetectable		 3ln1A-2pyjA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2pyj DNA POLYMERASE
(Bacillus
virus
phi29) 		4 / 7 LEU A  44
SER A  43
LEU A  58
PHE A  13
 None
 0.93A 3ln1B-2pyjA:
0.0		 3ln1B-2pyjA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2pyj DNA POLYMERASE
(Bacillus
virus
phi29) 		4 / 7 LEU A 389
SER A 388
LEU A 263
PHE A 393
 None
 0.93A 3ln1B-2pyjA:
0.0		 3ln1B-2pyjA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_2
(P38A)		 2pyj DNA POLYMERASE
(Bacillus
virus
phi29) 		3 / 3 GLU A 221
LEU A 351
LEU A 333
 None
None
EDO  A2771 (-4.8A)
 0.65A 3ohtA-2pyjA:
undetectable		 3ohtA-2pyjA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_2
(P38A)		 2pyj DNA POLYMERASE
(Bacillus
virus
phi29) 		3 / 3 GLU A 221
LEU A 351
LEU A 333
 None
None
EDO  A2771 (-4.8A)
 0.65A 3ohtB-2pyjA:
undetectable		 3ohtB-2pyjA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2pyj DNA POLYMERASE
(Bacillus
virus
phi29) 		5 / 12 VAL A  54
PHE A  47
ILE A 105
ILE A 119
LEU A  44
 None
 1.09A 3w67D-2pyjA:
undetectable		 3w67D-2pyjA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AF0_A_MOAA1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 2pyj DNA POLYMERASE
(Bacillus
virus
phi29) 		4 / 8 ASP A 219
SER A 395
ASN A 396
GLY A 430
 None
 0.90A 4af0A-2pyjA:
undetectable		 4af0A-2pyjA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAJ_B_0HKB2000_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 2pyj DNA POLYMERASE
(Bacillus
virus
phi29) 		5 / 12 THR A 457
THR A 441
ALA A 445
TYR A 454
TYR A 500
 DGT  A1588 ( 4.3A)
None
None
None
None
 1.43A 4dajB-2pyjA:
undetectable		 4dajB-2pyjA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_A_0HKA1201_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 2pyj DNA POLYMERASE
(Bacillus
virus
phi29) 		5 / 12 THR A 457
THR A 441
ALA A 445
TYR A 454
TYR A 500
 DGT  A1588 ( 4.3A)
None
None
None
None
 1.49A 5dsgA-2pyjA:
undetectable		 5dsgA-2pyjA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_1_BEZ1801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2pyj DNA POLYMERASE
(Bacillus
virus
phi29) 		3 / 3 LEU A 462
PHE A 489
ILE A 453
 None
 0.70A 5dzk1-2pyjA:
undetectable
5dzkF-2pyjA:
undetectable
5dzkM-2pyjA:
undetectable		 5dzk1-2pyjA:
1.12
5dzkF-2pyjA:
15.97
5dzkM-2pyjA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 2pyj DNA POLYMERASE
(Bacillus
virus
phi29) 		4 / 8 LEU A 342
LEU A 328
THR A 301
GLN A 446
 None
 1.13A 5hbsA-2pyjA:
undetectable		 5hbsA-2pyjA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHC_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 2pyj DNA POLYMERASE
(Bacillus
virus
phi29) 		3 / 3 PHE A 198
ASP A 200
LEU A 381
 None
 0.75A 5uhcC-2pyjA:
undetectable		 5uhcC-2pyjA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA502_1
(CYTOCHROME P450 2C9)		 2pyj DNA POLYMERASE
(Bacillus
virus
phi29) 		5 / 12 PHE A 393
LEU A 214
VAL A 222
VAL A 431
THR A 356
 None
 1.08A 5x24A-2pyjA:
undetectable		 5x24A-2pyjA:
21.44