SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pyt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1P33_D_MTXD354_1 (PTERIDINE REDUCTASE 1)	2pyt	ETHANOLAMINE UTILIZATION PROTEIN EUTQ (Salmonella enterica)	5 / 12	SER A 111 PRO A 107 ASP A 149 LEU A 218 TYR A 219	None	1.42A	1p33D-2pytA: undetectable	1p33D-2pytA: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2W98_A_P1ZA1353_1 (PROSTAGLANDIN REDUCTASE 2)	2pyt	ETHANOLAMINE UTILIZATION PROTEIN EUTQ (Salmonella enterica)	5 / 9	THR A 142 PHE A 131 VAL A 126 PHE A 217 GLU A 179	None	1.43A	2w98A-2pytA: undetectable	2w98A-2pytA: 19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EL5_B_1UNB201_2 (PROTEASE)	2pyt	ETHANOLAMINE UTILIZATION PROTEIN EUTQ (Salmonella enterica)	5 / 12	ALA A 195 VAL A 215 THR A 211 PRO A 212 THR A 213	None	0.79A	3el5B-2pytA: undetectable	3el5B-2pytA: 22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6CLX_B_SAMB401_0 (O-METHYLTRANSFERASE)	2pyt	ETHANOLAMINE UTILIZATION PROTEIN EUTQ (Salmonella enterica)	5 / 10	ALA A 221 GLY A 156 SER A 108 PHE A 109 ASP A 149	None	1.44A	6clxB-2pytA: undetectable	6clxB-2pytA: 15.24

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1P33_D_MTXD354_1","PTERIDINE REDUCTASE 1","2pyt","ETHANOLAMINE UTILIZATION PROTEIN EUTQ","Salmonella enterica",5,"SER A 111;PRO A 107;ASP A 149;LEU A 218;TYR A 219","None","1.42A","1p33D-2pytA:undetectable","1p33D-2pytA:20.00"],["2W98_A_P1ZA1353_1","PROSTAGLANDIN REDUCTASE 2","2pyt","ETHANOLAMINE UTILIZATION PROTEIN EUTQ","Salmonella enterica",5,"THR A 142;PHE A 131;VAL A 126;PHE A 217;GLU A 179","None","1.43A","2w98A-2pytA:undetectable","2w98A-2pytA:19.54"],["3EL5_B_1UNB201_2","PROTEASE","2pyt","ETHANOLAMINE UTILIZATION PROTEIN EUTQ","Salmonella enterica",5,"ALA A 195;VAL A 215;THR A 211;PRO A 212;THR A 213","None","0.79A","3el5B-2pytA:undetectable","3el5B-2pytA:22.06"],["6CLX_B_SAMB401_0","O-METHYLTRANSFERASE","2pyt","ETHANOLAMINE UTILIZATION PROTEIN EUTQ","Salmonella enterica",5,"ALA A 221;GLY A 156;SER A 108;PHE A 109;ASP A 149","None","1.44A","6clxB-2pytA:undetectable","6clxB-2pytA:15.24"]]