SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pyw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_A_SAMA105_0
(MET REPRESSOR)		 2pyw UNCHARACTERIZED
PROTEIN
(Arabidopsis
thaliana) 		5 / 10 ALA A 221
PHE A 186
ARG A 403
LEU A 400
GLU A 219
 None
 1.28A 1cmcA-2pywA:
undetectable
1cmcB-2pywA:
undetectable		 1cmcA-2pywA:
15.08
1cmcB-2pywA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 2pyw UNCHARACTERIZED
PROTEIN
(Arabidopsis
thaliana) 		5 / 12 PRO A  67
ASN A  48
GLN A  64
PHE A  51
VAL A  42
 None
ADP  A 999 (-3.9A)
None
None
None
 1.22A 1ffyA-2pywA:
undetectable		 1ffyA-2pywA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHV_A_NOGA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 2pyw UNCHARACTERIZED
PROTEIN
(Arabidopsis
thaliana) 		4 / 8 SER A  13
THR A 110
MET A 111
LEU A   9
 None
 1.11A 1lhvA-2pywA:
undetectable		 1lhvA-2pywA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_D_AG2D7015_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 2pyw UNCHARACTERIZED
PROTEIN
(Arabidopsis
thaliana) 		4 / 7 LEU A 399
LEU A 352
LEU A 272
GLY A 273
 None
 0.87A 1n13D-2pywA:
undetectable
1n13E-2pywA:
undetectable		 1n13D-2pywA:
13.90
1n13E-2pywA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)		 2pyw UNCHARACTERIZED
PROTEIN
(Arabidopsis
thaliana) 		5 / 12 PHE A 310
LEU A 309
THR A 150
LEU A 317
LEU A 151
 None
 1.21A 1og5A-2pywA:
undetectable		 1og5A-2pywA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X1A_A_SAMA4264_0
(CRTF-RELATED PROTEIN)		 2pyw UNCHARACTERIZED
PROTEIN
(Arabidopsis
thaliana) 		5 / 12 ALA A 233
GLY A 269
GLY A 265
ILE A 235
LEU A 356
 None
 1.12A 1x1aA-2pywA:
undetectable		 1x1aA-2pywA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_A_SAMA301_0
(RRNA
METHYLTRANSFERASE)		 2pyw UNCHARACTERIZED
PROTEIN
(Arabidopsis
thaliana) 		5 / 11 GLU A 374
GLY A 129
ILE A 379
ALA A 278
ALA A 281
 None
 1.03A 1x7pA-2pywA:
undetectable
1x7pB-2pywA:
undetectable		 1x7pA-2pywA:
20.65
1x7pB-2pywA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA502_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 2pyw UNCHARACTERIZED
PROTEIN
(Arabidopsis
thaliana) 		3 / 3 LEU A  96
HIS A  93
LYS A  92
 None
 0.98A 1y7iA-2pywA:
undetectable		 1y7iA-2pywA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2pyw UNCHARACTERIZED
PROTEIN
(Arabidopsis
thaliana) 		4 / 6 LEU A 151
ILE A 268
ILE A 299
LEU A 139
 None
 0.91A 2xkwB-2pywA:
undetectable		 2xkwB-2pywA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_B_THHB401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 2pyw UNCHARACTERIZED
PROTEIN
(Arabidopsis
thaliana) 		4 / 8 ILE A 235
LEU A 234
ASN A 174
GLY A 262
 None
 0.72A 3dcjB-2pywA:
undetectable		 3dcjB-2pywA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2pyw UNCHARACTERIZED
PROTEIN
(Arabidopsis
thaliana) 		4 / 6 LEU A 399
PHE A 395
ILE A 416
ALA A 415
 None
 0.97A 3mdrA-2pywA:
undetectable		 3mdrA-2pywA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PEO_F_CU9F301_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2pyw UNCHARACTERIZED
PROTEIN
(Arabidopsis
thaliana) 		4 / 6 GLN A 232
TYR A 347
GLN A 344
SER A 155
 None
 1.08A 3peoG-2pywA:
undetectable		 3peoG-2pywA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WAR_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA)		 2pyw UNCHARACTERIZED
PROTEIN
(Arabidopsis
thaliana) 		6 / 8 VAL A  50
VAL A  61
LYS A  63
MET A 245
ILE A 254
ASP A 255
 ADP  A 999 (-4.3A)
ADP  A 999 (-4.6A)
ADP  A 999 (-2.7A)
ADP  A 999 (-3.5A)
ADP  A 999 ( 4.3A)
MG  A 500 (-1.8A)
 0.58A 3warA-2pywA:
9.7		 3warA-2pywA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CD2_A_FOLA207_0
(DIHYDROFOLATE
REDUCTASE)		 2pyw UNCHARACTERIZED
PROTEIN
(Arabidopsis
thaliana) 		5 / 12 ILE A 367
ALA A 386
ILE A 379
PHE A 376
THR A 199
 None
 1.25A 4cd2A-2pywA:
undetectable		 4cd2A-2pywA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 2pyw UNCHARACTERIZED
PROTEIN
(Arabidopsis
thaliana) 		3 / 3 PRO A 137
VAL A 246
HIS A 123
 None
 0.67A 4pevC-2pywA:
undetectable		 4pevC-2pywA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8V_B_MIYB1103_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2pyw UNCHARACTERIZED
PROTEIN
(Arabidopsis
thaliana) 		5 / 12 SER A 391
ILE A 416
ALA A 415
PHE A 406
VAL A 412
 None
 1.06A 4u8vB-2pywA:
undetectable		 4u8vB-2pywA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8Y_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2pyw UNCHARACTERIZED
PROTEIN
(Arabidopsis
thaliana) 		5 / 12 SER A 391
ILE A 416
ALA A 415
PHE A 406
VAL A 412
 None
 1.08A 4u8yB-2pywA:
3.5		 4u8yB-2pywA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 2pyw UNCHARACTERIZED
PROTEIN
(Arabidopsis
thaliana) 		5 / 12 LEU A 177
ILE A 235
ARG A 230
ARG A 179
LEU A 180
 None
None
None
None
SR1  A 998 ( 4.9A)
 1.15A 5h5fA-2pywA:
undetectable		 5h5fA-2pywA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		 2pyw UNCHARACTERIZED
PROTEIN
(Arabidopsis
thaliana) 		4 / 8 SER A 243
ASP A 255
PRO A 256
PHE A 258
 MG  A 501 ( 4.5A)
MG  A 500 (-1.8A)
None
SR1  A 998 (-4.2A)
 1.10A 5l1fA-2pywA:
1.6
5l1fB-2pywA:
1.8		 5l1fA-2pywA:
19.95
5l1fB-2pywA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA503_1
(CYTOCHROME P450 2C9)		 2pyw UNCHARACTERIZED
PROTEIN
(Arabidopsis
thaliana) 		4 / 5 PRO A 325
GLY A 324
ASN A 321
LYS A 322
 None
 1.06A 5x23A-2pywA:
undetectable		 5x23A-2pywA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA502_1
(CYTOCHROME P450 2C9)		 2pyw UNCHARACTERIZED
PROTEIN
(Arabidopsis
thaliana) 		4 / 6 PRO A 325
GLY A 324
ASN A 321
LYS A 322
 None
 1.09A 5xxiA-2pywA:
undetectable		 5xxiA-2pywA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 2pyw UNCHARACTERIZED
PROTEIN
(Arabidopsis
thaliana) 		6 / 8 VAL A  50
VAL A  61
LYS A  63
MET A 245
ILE A 254
ASP A 255
 ADP  A 999 (-4.3A)
ADP  A 999 (-4.6A)
ADP  A 999 (-2.7A)
ADP  A 999 (-3.5A)
ADP  A 999 ( 4.3A)
MG  A 500 (-1.8A)
 0.56A 5y9mA-2pywA:
8.8		 5y9mA-2pywA:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 2pyw UNCHARACTERIZED
PROTEIN
(Arabidopsis
thaliana) 		6 / 8 VAL A  50
VAL A  61
LYS A  63
MET A 245
ILE A 254
ASP A 255
 ADP  A 999 (-4.3A)
ADP  A 999 (-4.6A)
ADP  A 999 (-2.7A)
ADP  A 999 (-3.5A)
ADP  A 999 ( 4.3A)
MG  A 500 (-1.8A)
 0.57A 5y9mX-2pywA:
9.0		 5y9mX-2pywA:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_B_NIOB401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 2pyw UNCHARACTERIZED
PROTEIN
(Arabidopsis
thaliana) 		6 / 7 VAL A  50
VAL A  61
LYS A  63
MET A 245
ILE A 254
ASP A 255
 ADP  A 999 (-4.3A)
ADP  A 999 (-4.6A)
ADP  A 999 (-2.7A)
ADP  A 999 (-3.5A)
ADP  A 999 ( 4.3A)
MG  A 500 (-1.8A)
 0.62A 5yf9B-2pywA:
9.0		 5yf9B-2pywA:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 2pyw UNCHARACTERIZED
PROTEIN
(Arabidopsis
thaliana) 		6 / 9 VAL A  50
VAL A  61
LYS A  63
MET A 245
ILE A 254
ASP A 255
 ADP  A 999 (-4.3A)
ADP  A 999 (-4.6A)
ADP  A 999 (-2.7A)
ADP  A 999 (-3.5A)
ADP  A 999 ( 4.3A)
MG  A 500 (-1.8A)
 0.61A 5yf9X-2pywA:
8.8		 5yf9X-2pywA:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YWM_X_NIOX403_0
(CASEIN KINASE II
SUBUNIT ALPHA')		 2pyw UNCHARACTERIZED
PROTEIN
(Arabidopsis
thaliana) 		5 / 7 VAL A  50
VAL A  61
LYS A  63
ILE A 254
ASP A 255
 ADP  A 999 (-4.3A)
ADP  A 999 (-4.6A)
ADP  A 999 (-2.7A)
ADP  A 999 ( 4.3A)
MG  A 500 (-1.8A)
 0.53A 5ywmX-2pywA:
3.3		 5ywmX-2pywA:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YWM_X_NIOX403_0
(CASEIN KINASE II
SUBUNIT ALPHA')		 2pyw UNCHARACTERIZED
PROTEIN
(Arabidopsis
thaliana) 		4 / 7 VAL A 184
VAL A 370
ILE A  72
ILE A  69
 SR1  A 998 (-4.9A)
None
None
SR1  A 998 ( 4.8A)
 0.77A 5ywmX-2pywA:
3.3		 5ywmX-2pywA:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 2pyw UNCHARACTERIZED
PROTEIN
(Arabidopsis
thaliana) 		3 / 3 TYR A 158
LEU A 317
ASP A 145
 None
 0.72A 5zv2B-2pywA:
8.0		 5zv2B-2pywA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_1
(PROTEIN CYP51)		 2pyw UNCHARACTERIZED
PROTEIN
(Arabidopsis
thaliana) 		5 / 12 PHE A 186
ALA A 361
MET A 147
ALA A 140
LEU A 275
 None
 1.26A 6aycA-2pywA:
undetectable		 6aycA-2pywA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA807_0
(GEPHYRIN)		 2pyw UNCHARACTERIZED
PROTEIN
(Arabidopsis
thaliana) 		4 / 4 PRO A 102
LEU A  90
VAL A  61
ARG A 117
 None
None
ADP  A 999 (-4.6A)
None
 1.49A 6fgdA-2pywA:
undetectable		 6fgdA-2pywA:
23.29