SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pyy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_2
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 2pyy IONOTROPIC GLUTAMATE
RECEPTOR BACTERIAL
HOMOLOGUE
(Nostoc
punctiforme) 		3 / 3 LEU A  90
HIS A 128
ILE A 105
 None
 0.58A 1s9pB-2pyyA:
undetectable		 1s9pB-2pyyA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2pyy IONOTROPIC GLUTAMATE
RECEPTOR BACTERIAL
HOMOLOGUE
(Nostoc
punctiforme) 		5 / 12 PHE A 219
ILE A 198
LEU A  64
GLY A 185
ILE A  85
 None
 1.27A 2e7fA-2pyyA:
undetectable		 2e7fA-2pyyA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2pyy IONOTROPIC GLUTAMATE
RECEPTOR BACTERIAL
HOMOLOGUE
(Nostoc
punctiforme) 		5 / 12 PHE A 219
ILE A 198
LEU A  64
GLY A 185
ILE A  85
 None
 1.32A 2e7fB-2pyyA:
undetectable		 2e7fB-2pyyA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2pyy IONOTROPIC GLUTAMATE
RECEPTOR BACTERIAL
HOMOLOGUE
(Nostoc
punctiforme) 		5 / 12 PHE A 219
ILE A 198
LEU A  64
GLY A 185
ILE A  85
 None
 1.27A 2ogyA-2pyyA:
undetectable		 2ogyA-2pyyA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2pyy IONOTROPIC GLUTAMATE
RECEPTOR BACTERIAL
HOMOLOGUE
(Nostoc
punctiforme) 		5 / 12 PHE A 219
ILE A 198
LEU A  64
GLY A 185
ILE A  85
 None
 1.30A 2ogyB-2pyyA:
undetectable		 2ogyB-2pyyA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_A_ACHA1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2pyy IONOTROPIC GLUTAMATE
RECEPTOR BACTERIAL
HOMOLOGUE
(Nostoc
punctiforme) 		4 / 7 TYR A  47
SER A  49
ILE A  69
SER A  55
 None
None
GLU  A1620 (-4.9A)
None
 1.08A 2xz5A-2pyyA:
undetectable
2xz5B-2pyyA:
undetectable		 2xz5A-2pyyA:
20.88
2xz5B-2pyyA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2pyy IONOTROPIC GLUTAMATE
RECEPTOR BACTERIAL
HOMOLOGUE
(Nostoc
punctiforme) 		4 / 8 TYR A  47
SER A  49
ILE A  69
SER A  55
 None
None
GLU  A1620 (-4.9A)
None
 1.07A 2xz5B-2pyyA:
undetectable
2xz5E-2pyyA:
undetectable		 2xz5B-2pyyA:
20.88
2xz5E-2pyyA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YCJ_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2pyy IONOTROPIC GLUTAMATE
RECEPTOR BACTERIAL
HOMOLOGUE
(Nostoc
punctiforme) 		5 / 12 PHE A 219
ILE A 198
LEU A  64
GLY A 185
ILE A  85
 None
 1.32A 2ycjA-2pyyA:
undetectable		 2ycjA-2pyyA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_2
(HIV-1 PROTEASE)		 2pyy IONOTROPIC GLUTAMATE
RECEPTOR BACTERIAL
HOMOLOGUE
(Nostoc
punctiforme) 		3 / 3 ARG A 180
VAL A 153
THR A 115
 None
 0.84A 3k4vA-2pyyA:
undetectable		 3k4vA-2pyyA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_3
(PROTEASE)		 2pyy IONOTROPIC GLUTAMATE
RECEPTOR BACTERIAL
HOMOLOGUE
(Nostoc
punctiforme) 		3 / 3 ARG A 180
VAL A 153
THR A 115
 None
 0.84A 3nduD-2pyyA:
undetectable		 3nduD-2pyyA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R75_A_BEZA701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 2pyy IONOTROPIC GLUTAMATE
RECEPTOR BACTERIAL
HOMOLOGUE
(Nostoc
punctiforme) 		5 / 12 GLU A 182
SER A 119
GLY A 118
THR A 115
GLU A 134
 None
GLU  A1620 (-4.7A)
None
None
None
 1.48A 3r75A-2pyyA:
undetectable		 3r75A-2pyyA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R75_A_BEZA701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 2pyy IONOTROPIC GLUTAMATE
RECEPTOR BACTERIAL
HOMOLOGUE
(Nostoc
punctiforme) 		5 / 12 ILE A  69
SER A  70
GLU A 182
SER A 119
THR A 120
 GLU  A1620 (-4.9A)
GLU  A1620 (-2.9A)
None
GLU  A1620 (-4.7A)
GLU  A1620 (-3.4A)
 1.41A 3r75A-2pyyA:
undetectable		 3r75A-2pyyA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R75_B_BEZB701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 2pyy IONOTROPIC GLUTAMATE
RECEPTOR BACTERIAL
HOMOLOGUE
(Nostoc
punctiforme) 		5 / 12 GLU A 182
SER A 119
GLY A 118
THR A 115
GLU A 134
 None
GLU  A1620 (-4.7A)
None
None
None
 1.50A 3r75B-2pyyA:
undetectable		 3r75B-2pyyA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R75_B_BEZB701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 2pyy IONOTROPIC GLUTAMATE
RECEPTOR BACTERIAL
HOMOLOGUE
(Nostoc
punctiforme) 		5 / 12 ILE A  69
SER A  70
GLU A 182
SER A 119
THR A 120
 GLU  A1620 (-4.9A)
GLU  A1620 (-2.9A)
None
GLU  A1620 (-4.7A)
GLU  A1620 (-3.4A)
 1.41A 3r75B-2pyyA:
undetectable		 3r75B-2pyyA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R76_A_BEZA701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 2pyy IONOTROPIC GLUTAMATE
RECEPTOR BACTERIAL
HOMOLOGUE
(Nostoc
punctiforme) 		5 / 11 GLU A 182
SER A 119
GLY A 118
THR A 115
GLU A 134
 None
GLU  A1620 (-4.7A)
None
None
None
 1.45A 3r76A-2pyyA:
2.2		 3r76A-2pyyA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R76_B_BEZB701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 2pyy IONOTROPIC GLUTAMATE
RECEPTOR BACTERIAL
HOMOLOGUE
(Nostoc
punctiforme) 		5 / 11 GLU A 182
SER A 119
GLY A 118
THR A 115
GLU A 134
 None
GLU  A1620 (-4.7A)
None
None
None
 1.46A 3r76B-2pyyA:
2.3		 3r76B-2pyyA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_C_QMRC1214_1
(CAPITELLA TELETA
ACHBP)		 2pyy IONOTROPIC GLUTAMATE
RECEPTOR BACTERIAL
HOMOLOGUE
(Nostoc
punctiforme) 		4 / 8 VAL A  94
TYR A 163
ILE A  92
ILE A 174
 None
 0.67A 4afgD-2pyyA:
undetectable
4afgE-2pyyA:
undetectable		 4afgD-2pyyA:
24.11
4afgE-2pyyA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_A_CAMA1419_0
(CYTOCHROME P450)		 2pyy IONOTROPIC GLUTAMATE
RECEPTOR BACTERIAL
HOMOLOGUE
(Nostoc
punctiforme) 		5 / 12 ILE A 105
THR A 115
VAL A 113
ILE A 130
VAL A 132
 None
 1.05A 4c9lA-2pyyA:
undetectable		 4c9lA-2pyyA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_B_CAMB1419_0
(CYTOCHROME P450)		 2pyy IONOTROPIC GLUTAMATE
RECEPTOR BACTERIAL
HOMOLOGUE
(Nostoc
punctiforme) 		5 / 12 ILE A 105
THR A 115
VAL A 113
ILE A 130
VAL A 132
 None
 1.04A 4c9lB-2pyyA:
undetectable		 4c9lB-2pyyA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2pyy IONOTROPIC GLUTAMATE
RECEPTOR BACTERIAL
HOMOLOGUE
(Nostoc
punctiforme) 		4 / 5 ARG A  32
VAL A  16
LEU A  17
SER A  18
 None
 1.14A 4e1gA-2pyyA:
undetectable		 4e1gA-2pyyA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2pyy IONOTROPIC GLUTAMATE
RECEPTOR BACTERIAL
HOMOLOGUE
(Nostoc
punctiforme) 		4 / 6 PHE A  81
ILE A  71
ARG A  75
VAL A  50
 None
None
GLU  A1620 (-2.9A)
GLU  A1620 (-4.9A)
 1.32A 4mk4B-2pyyA:
undetectable		 4mk4B-2pyyA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0R_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 2pyy IONOTROPIC GLUTAMATE
RECEPTOR BACTERIAL
HOMOLOGUE
(Nostoc
punctiforme) 		5 / 12 VAL A   7
ILE A 186
LEU A  64
ILE A 198
ILE A  34
 None
 0.90A 4y0rA-2pyyA:
undetectable		 4y0rA-2pyyA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_A_ACTA401_0
(PROTON-GATED ION
CHANNEL)		 2pyy IONOTROPIC GLUTAMATE
RECEPTOR BACTERIAL
HOMOLOGUE
(Nostoc
punctiforme) 		4 / 6 ILE A  69
PHE A  81
ARG A  75
ILE A  54
 GLU  A1620 (-4.9A)
None
GLU  A1620 (-2.9A)
None
 1.18A 4zzcA-2pyyA:
undetectable
4zzcB-2pyyA:
undetectable		 4zzcA-2pyyA:
23.29
4zzcB-2pyyA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_B_ACTB401_0
(PROTON-GATED ION
CHANNEL)		 2pyy IONOTROPIC GLUTAMATE
RECEPTOR BACTERIAL
HOMOLOGUE
(Nostoc
punctiforme) 		4 / 6 ILE A  69
PHE A  81
ARG A  75
ILE A  54
 GLU  A1620 (-4.9A)
None
GLU  A1620 (-2.9A)
None
 1.20A 4zzcB-2pyyA:
undetectable
4zzcC-2pyyA:
undetectable		 4zzcB-2pyyA:
23.29
4zzcC-2pyyA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_H_DVAH9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 2pyy IONOTROPIC GLUTAMATE
RECEPTOR BACTERIAL
HOMOLOGUE
(Nostoc
punctiforme) 		3 / 3 ALA A 201
ASN A 204
LEU A 205
 None
 0.49A 5i1oA-2pyyA:
undetectable		 5i1oA-2pyyA:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2pyy IONOTROPIC GLUTAMATE
RECEPTOR BACTERIAL
HOMOLOGUE
(Nostoc
punctiforme) 		4 / 7 ALA A 122
THR A 123
TYR A 124
VAL A 132
 None
 0.94A 6cduA-2pyyA:
undetectable
6cduE-2pyyA:
undetectable		 6cduA-2pyyA:
22.48
6cduE-2pyyA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_H_EY4H500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2pyy IONOTROPIC GLUTAMATE
RECEPTOR BACTERIAL
HOMOLOGUE
(Nostoc
punctiforme) 		4 / 7 VAL A 132
ALA A 122
THR A 123
TYR A 124
 None
 0.91A 6cduH-2pyyA:
undetectable
6cduI-2pyyA:
undetectable		 6cduH-2pyyA:
22.48
6cduI-2pyyA:
22.48