SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pz0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_C_DESC500_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 2pz0 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Caldanaerobacter
subterraneus) 		5 / 12 LEU A 214
LEU A 192
LEU A 171
ARG A 186
ILE A 199
 None
 1.07A 1s9pC-2pz0A:
undetectable		 1s9pC-2pz0A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_2
(POL POLYPROTEIN)		 2pz0 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Caldanaerobacter
subterraneus) 		4 / 7 ASP A 234
GLY A  42
ILE A  43
THR A 218
 None
 0.82A 1t7jB-2pz0A:
undetectable		 1t7jB-2pz0A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T87_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 2pz0 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Caldanaerobacter
subterraneus) 		4 / 7 LEU A  55
VAL A  47
VAL A 147
ILE A 149
 None
 0.99A 1t87B-2pz0A:
undetectable		 1t87B-2pz0A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		 2pz0 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Caldanaerobacter
subterraneus) 		3 / 3 GLU A 119
HIS A  17
GLU A  44
 CA  A 501 ( 3.2A)
GOL  A 401 (-3.8A)
CA  A 501 ( 2.9A)
 0.80A 2x45B-2pz0A:
undetectable		 2x45B-2pz0A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		 2pz0 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Caldanaerobacter
subterraneus) 		3 / 3 GLU A 119
HIS A  17
GLU A  44
 CA  A 501 ( 3.2A)
GOL  A 401 (-3.8A)
CA  A 501 ( 2.9A)
 0.83A 2x45C-2pz0A:
undetectable		 2x45C-2pz0A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_4
(HIV-1 PROTEASE)		 2pz0 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Caldanaerobacter
subterraneus) 		4 / 4 LEU A  84
ASP A  46
VAL A  56
THR A  50
 None
CA  A 501 (-2.8A)
None
None
 1.29A 3cyxB-2pz0A:
undetectable		 3cyxB-2pz0A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_C_DSFC320_1
(GLR4197 PROTEIN)		 2pz0 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Caldanaerobacter
subterraneus) 		4 / 8 ILE A 135
ILE A 138
VAL A 160
ILE A 118
 None
 0.80A 3p4wC-2pz0A:
undetectable		 3p4wC-2pz0A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SM2_A_478A126_2
(GAG-PRO-POL
POLYPROTEIN)		 2pz0 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Caldanaerobacter
subterraneus) 		5 / 11 VAL A 105
VAL A 116
GLY A  42
ALA A  40
LEU A 108
 None
 1.03A 3sm2B-2pz0A:
undetectable		 3sm2B-2pz0A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		 2pz0 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Caldanaerobacter
subterraneus) 		4 / 7 ILE A  29
ILE A 109
GLU A  44
VAL A  57
 None
None
CA  A 501 ( 2.9A)
None
 0.84A 3ua5B-2pz0A:
undetectable		 3ua5B-2pz0A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_B_ASWB1301_1
(DNA TOPOISOMERASE
2-BETA)		 2pz0 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Caldanaerobacter
subterraneus) 		4 / 7 PRO A  25
GLY A  96
ALA A  30
GLU A  97
 None
 0.95A 4g0uB-2pz0A:
undetectable		 4g0uB-2pz0A:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_F_ASWF101_1
(DNA TOPOISOMERASE
2-BETA)		 2pz0 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Caldanaerobacter
subterraneus) 		4 / 6 PRO A  25
GLY A  96
ALA A  30
GLU A  97
 None
 1.02A 4g0uA-2pz0A:
undetectable		 4g0uA-2pz0A:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4C_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 2pz0 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Caldanaerobacter
subterraneus) 		4 / 8 LEU A  55
VAL A  47
VAL A 147
ILE A 149
 None
 0.86A 4l4cB-2pz0A:
undetectable		 4l4cB-2pz0A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		 2pz0 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Caldanaerobacter
subterraneus) 		3 / 3 LYS A  22
ASN A  27
ASP A 240
 None
 0.84A 4o1eA-2pz0A:
10.8		 4o1eA-2pz0A:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)		 2pz0 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Caldanaerobacter
subterraneus) 		5 / 12 ILE A  15
LEU A 115
HIS A 193
GLY A 235
ASP A 234
 None
 0.97A 5nnaA-2pz0A:
undetectable		 5nnaA-2pz0A:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)		 2pz0 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Caldanaerobacter
subterraneus) 		5 / 12 ILE A  15
LEU A 115
HIS A 193
GLY A 235
ASP A 234
 None
 0.97A 5nnaB-2pz0A:
undetectable		 5nnaB-2pz0A:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_C_BZMC301_0
(ISATIN HYDROLASE A)		 2pz0 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Caldanaerobacter
subterraneus) 		5 / 12 ILE A  15
LEU A 115
HIS A 193
GLY A 235
ASP A 234
 None
 0.97A 5nnaC-2pz0A:
undetectable		 5nnaC-2pz0A:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_D_BZMD301_0
(ISATIN HYDROLASE A)		 2pz0 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Caldanaerobacter
subterraneus) 		5 / 12 ILE A  15
LEU A 115
HIS A 193
GLY A 235
ASP A 234
 None
 0.97A 5nnaD-2pz0A:
undetectable		 5nnaD-2pz0A:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_A_ACTA703_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 2pz0 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Caldanaerobacter
subterraneus) 		4 / 6 ARG A  34
ALA A  31
PRO A  25
PHE A  94
 None
 1.17A 5odqA-2pz0A:
undetectable		 5odqA-2pz0A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_A_SAMA501_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 2pz0 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Caldanaerobacter
subterraneus) 		5 / 12 LEU A 134
ILE A 130
GLY A 129
ILE A 149
ASP A 159
 None
 1.01A 6emuA-2pz0A:
undetectable		 6emuA-2pz0A:
26.05