SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pz1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_2
(LIVER
CARBOXYLESTERASE I)		 2pz1 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
(Homo
sapiens) 		3 / 3 PHE A 521
LEU A 586
LEU A 575
 None
 0.54A 1mx1E-2pz1A:
undetectable		 1mx1E-2pz1A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOX_A_THAA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 2pz1 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
(Homo
sapiens) 		4 / 8 PHE A 365
GLU A 296
GLN A 340
TYR A 375
 None
 1.25A 2aoxA-2pz1A:
undetectable		 2aoxA-2pz1A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA701_0
(FERROCHELATASE)		 2pz1 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
(Homo
sapiens) 		4 / 8 LEU A 293
ARG A 285
VAL A 451
GLY A 362
 None
 0.95A 2qd5A-2pz1A:
undetectable		 2qd5A-2pz1A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_A_ACTA501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 2pz1 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
(Homo
sapiens) 		4 / 7 ASP A 447
ARG A 285
VAL A 288
ILE A 292
 None
 1.03A 2yfbA-2pz1A:
2.2		 2yfbA-2pz1A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_B_ACTB501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 2pz1 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
(Homo
sapiens) 		4 / 6 ASP A 447
ARG A 285
VAL A 288
ILE A 292
 None
 1.10A 2yfbB-2pz1A:
4.8		 2yfbB-2pz1A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_A_DESA600_1
(ESTROGEN RECEPTOR
ALPHA)		 2pz1 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
(Homo
sapiens) 		5 / 12 ALA A 600
LEU A 528
LEU A 523
LEU A 500
LEU A 506
 None
 1.19A 3erdA-2pz1A:
undetectable		 3erdA-2pz1A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGG_A_CHDA211_0
(CMER)		 2pz1 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
(Homo
sapiens) 		4 / 7 CYH A 405
PHE A 330
PHE A 401
TYR A 398
 None
 1.31A 3hggA-2pz1A:
2.2		 3hggA-2pz1A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S79_A_ASDA601_1
(CYTOCHROME P450 19A1)		 2pz1 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
(Homo
sapiens) 		5 / 12 PHE A 372
ILE A 300
THR A 295
LEU A 434
MET A 458
 None
 1.15A 3s79A-2pz1A:
undetectable		 3s79A-2pz1A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		 2pz1 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
(Homo
sapiens) 		4 / 7 ILE A 329
PHE A 330
GLN A 325
PHE A 321
 None
 1.18A 3tvxB-2pz1A:
undetectable		 3tvxB-2pz1A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYK_B_IMNB300_1
(LACTOYLGLUTATHIONE
LYASE)		 2pz1 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
(Homo
sapiens) 		5 / 12 PHE A 573
LEU A 506
GLY A 551
MET A 549
LEU A 547
 None
 1.28A 4kykA-2pz1A:
undetectable
4kykB-2pz1A:
undetectable		 4kykA-2pz1A:
17.20
4kykB-2pz1A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4D_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 2pz1 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
(Homo
sapiens) 		4 / 8 THR A 441
LEU A 455
VAL A 451
VAL A 288
 None
 1.11A 4l4dA-2pz1A:
undetectable		 4l4dA-2pz1A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4E_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 2pz1 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
(Homo
sapiens) 		4 / 8 THR A 441
LEU A 455
VAL A 451
VAL A 288
 None
 1.13A 4l4eA-2pz1A:
undetectable		 4l4eA-2pz1A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4F_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 2pz1 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
(Homo
sapiens) 		4 / 8 THR A 441
LEU A 455
VAL A 451
VAL A 288
 None
 1.13A 4l4fA-2pz1A:
undetectable		 4l4fA-2pz1A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 2pz1 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
(Homo
sapiens) 		4 / 8 ARG A 605
ASP A 525
SER A 498
ARG A 496
 None
 1.12A 4lv9A-2pz1A:
undetectable
4lv9B-2pz1A:
undetectable		 4lv9A-2pz1A:
20.70
4lv9B-2pz1A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_B_SAMB301_0
(PUTATIVE RNA
METHYLASE)		 2pz1 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
(Homo
sapiens) 		5 / 12 THR A 328
GLY A 331
ASN A 332
SER A 322
ASN A 384
 None
 1.27A 4pooB-2pz1A:
undetectable		 4pooB-2pz1A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKV_A_ASDA602_1
(AROMATASE)		 2pz1 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
(Homo
sapiens) 		5 / 12 PHE A 372
ILE A 300
THR A 295
LEU A 434
MET A 458
 None
 1.14A 5jkvA-2pz1A:
undetectable		 5jkvA-2pz1A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_1
(REGULATORY PROTEIN
TETR)		 2pz1 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
(Homo
sapiens) 		4 / 8 ILE A 292
GLN A 340
TYR A 299
ASP A 447
 None
 1.15A 5vlmF-2pz1A:
undetectable		 5vlmF-2pz1A:
19.04