SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pz8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1200_1
(SERUM ALBUMIN)		 2pz8 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Bacillus
anthracis) 		4 / 4 LEU A  80
ILE A 147
ILE A  76
ALA A  77
 APC  A3001 (-4.1A)
None
None
None
 0.85A 2i30A-2pz8A:
undetectable		 2i30A-2pz8A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA801_1
(TRANSPORTER)		 2pz8 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Bacillus
anthracis) 		5 / 11 LEU A  58
LEU A  54
ARG A  57
ILE A  23
ALA A 199
 None
 1.21A 2q72A-2pz8A:
undetectable		 2q72A-2pz8A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_B_CGEB501_1
(CYTOCHROME P450 2B4)		 2pz8 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Bacillus
anthracis) 		4 / 8 ILE A  76
ALA A 146
THR A 143
VAL A 104
 None
 0.85A 3me6B-2pz8A:
undetectable		 3me6B-2pz8A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2pz8 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Bacillus
anthracis) 		4 / 7 ASP A  51
ASP A 159
ASP A 233
GLU A 163
 APC  A3001 (-3.7A)
None
None
APC  A3001 ( 4.6A)
 1.09A 4feuB-2pz8A:
undetectable		 4feuB-2pz8A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2pz8 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Bacillus
anthracis) 		4 / 8 ASP A  51
ASP A 159
ASP A 233
GLU A 163
 APC  A3001 (-3.7A)
None
None
APC  A3001 ( 4.6A)
 1.07A 4feuD-2pz8A:
undetectable		 4feuD-2pz8A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2pz8 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Bacillus
anthracis) 		4 / 8 ASP A  51
ASP A 159
ASP A 233
GLU A 163
 APC  A3001 (-3.7A)
None
None
APC  A3001 ( 4.6A)
 1.06A 4feuF-2pz8A:
undetectable		 4feuF-2pz8A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2pz8 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Bacillus
anthracis) 		4 / 7 ASP A  51
ASP A 159
ASP A 233
GLU A 163
 APC  A3001 (-3.7A)
None
None
APC  A3001 ( 4.6A)
 1.11A 4fevB-2pz8A:
undetectable		 4fevB-2pz8A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2pz8 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Bacillus
anthracis) 		4 / 7 ASP A  51
ASP A 159
ASP A 233
GLU A 163
 APC  A3001 (-3.7A)
None
None
APC  A3001 ( 4.6A)
 1.11A 4fevD-2pz8A:
undetectable		 4fevD-2pz8A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2pz8 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Bacillus
anthracis) 		4 / 7 ASP A  51
ASP A 159
ASP A 233
GLU A 163
 APC  A3001 (-3.7A)
None
None
APC  A3001 ( 4.6A)
 1.10A 4fevF-2pz8A:
undetectable		 4fevF-2pz8A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2pz8 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Bacillus
anthracis) 		4 / 7 ASP A  51
ASP A 159
ASP A 233
GLU A 163
 APC  A3001 (-3.7A)
None
None
APC  A3001 ( 4.6A)
 1.10A 4fewB-2pz8A:
undetectable		 4fewB-2pz8A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2pz8 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Bacillus
anthracis) 		4 / 8 ASP A  51
ASP A 159
ASP A 233
GLU A 163
 APC  A3001 (-3.7A)
None
None
APC  A3001 ( 4.6A)
 1.12A 4fewD-2pz8A:
undetectable		 4fewD-2pz8A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2pz8 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Bacillus
anthracis) 		4 / 8 ASP A  51
ASP A 159
ASP A 233
GLU A 163
 APC  A3001 (-3.7A)
None
None
APC  A3001 ( 4.6A)
 1.11A 4fewF-2pz8A:
undetectable		 4fewF-2pz8A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEX_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2pz8 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Bacillus
anthracis) 		4 / 7 ASP A  51
ASP A 159
ASP A 233
GLU A 163
 APC  A3001 (-3.7A)
None
None
APC  A3001 ( 4.6A)
 1.14A 4fexB-2pz8A:
undetectable		 4fexB-2pz8A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2pz8 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Bacillus
anthracis) 		4 / 8 ASP A  51
ASP A 159
ASP A 233
GLU A 163
 APC  A3001 (-3.7A)
None
None
APC  A3001 ( 4.6A)
 1.12A 4gkhB-2pz8A:
undetectable		 4gkhB-2pz8A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2pz8 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Bacillus
anthracis) 		4 / 8 ASP A  51
ASP A 159
ASP A 233
GLU A 163
 APC  A3001 (-3.7A)
None
None
APC  A3001 ( 4.6A)
 1.10A 4gkhD-2pz8A:
undetectable		 4gkhD-2pz8A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2pz8 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Bacillus
anthracis) 		4 / 8 ASP A  51
ASP A 159
ASP A 233
GLU A 163
 APC  A3001 (-3.7A)
None
None
APC  A3001 ( 4.6A)
 1.14A 4gkhF-2pz8A:
undetectable		 4gkhF-2pz8A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2pz8 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Bacillus
anthracis) 		4 / 7 ASP A  51
ASP A 159
ASP A 233
GLU A 163
 APC  A3001 (-3.7A)
None
None
APC  A3001 ( 4.6A)
 1.12A 4gkhG-2pz8A:
undetectable		 4gkhG-2pz8A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_J_KANJ301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2pz8 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Bacillus
anthracis) 		4 / 6 ASP A  51
ASP A 159
ASP A 233
GLU A 163
 APC  A3001 (-3.7A)
None
None
APC  A3001 ( 4.6A)
 1.11A 4gkhJ-2pz8A:
undetectable		 4gkhJ-2pz8A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_K_KANK301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2pz8 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Bacillus
anthracis) 		4 / 8 ASP A  51
ASP A 159
ASP A 233
GLU A 163
 APC  A3001 (-3.7A)
None
None
APC  A3001 ( 4.6A)
 1.10A 4gkhC-2pz8A:
undetectable
4gkhK-2pz8A:
undetectable		 4gkhC-2pz8A:
21.57
4gkhK-2pz8A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2pz8 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Bacillus
anthracis) 		4 / 8 ASP A  51
ASP A 159
ASP A 233
GLU A 163
 APC  A3001 (-3.7A)
None
None
APC  A3001 ( 4.6A)
 1.13A 4gkiA-2pz8A:
undetectable		 4gkiA-2pz8A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_C_KANC301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2pz8 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Bacillus
anthracis) 		4 / 8 ASP A  51
ASP A 159
ASP A 233
GLU A 163
 APC  A3001 (-3.7A)
None
None
APC  A3001 ( 4.6A)
 1.12A 4gkiC-2pz8A:
undetectable		 4gkiC-2pz8A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2pz8 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Bacillus
anthracis) 		4 / 8 ASP A  51
ASP A 159
ASP A 233
GLU A 163
 APC  A3001 (-3.7A)
None
None
APC  A3001 ( 4.6A)
 1.12A 4gkiE-2pz8A:
undetectable
4gkiG-2pz8A:
undetectable		 4gkiE-2pz8A:
21.57
4gkiG-2pz8A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 2pz8 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Bacillus
anthracis) 		4 / 6 GLY A  48
ASP A 211
ASP A  51
ASP A  90
 None
GOL  A3309 (-3.2A)
APC  A3001 (-3.7A)
None
 0.96A 4uckB-2pz8A:
undetectable		 4uckB-2pz8A:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_B_ESTB1000_1
(ESTROGEN RECEPTOR)		 2pz8 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Bacillus
anthracis) 		5 / 10 LEU A  58
ALA A  62
GLU A  65
ARG A  24
LEU A 179
 None
 1.35A 5dxeB-2pz8A:
undetectable		 5dxeB-2pz8A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2pz8 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Bacillus
anthracis) 		3 / 3 ASP A 159
LEU A 225
ARG A 252
 None
 0.92A 5e8qA-2pz8A:
undetectable		 5e8qA-2pz8A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JO9_A_SORA302_0
(RIBITOL
2-DEHYDROGENASE)		 2pz8 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Bacillus
anthracis) 		5 / 12 LEU A 179
THR A  37
VAL A  27
PHE A  42
LEU A 154
 None
 1.47A 5jo9A-2pz8A:
2.1		 5jo9A-2pz8A:
23.23