SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pzd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_B_URFB400_1
(URIDINE
PHOSPHORYLASE 1)		 2pzd SERINE PROTEASE
HTRA2
(Homo
sapiens) 		4 / 8 GLY A 406
ARG A 443
LEU A 450
ILE A 441
 None
 0.87A 3nbqB-2pzdA:
undetectable		 3nbqB-2pzdA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_C_URFC400_1
(URIDINE
PHOSPHORYLASE 1)		 2pzd SERINE PROTEASE
HTRA2
(Homo
sapiens) 		4 / 8 GLY A 406
ARG A 443
LEU A 450
ILE A 441
 None
 0.87A 3nbqC-2pzdA:
undetectable		 3nbqC-2pzdA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_D_URFD400_1
(URIDINE
PHOSPHORYLASE 1)		 2pzd SERINE PROTEASE
HTRA2
(Homo
sapiens) 		5 / 9 GLY A 406
ARG A 443
LEU A 407
LEU A 450
ILE A 441
 None
 1.36A 3nbqD-2pzdA:
undetectable		 3nbqD-2pzdA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2pzd SERINE PROTEASE
HTRA2
(Homo
sapiens) 		5 / 12 ILE A 413
ILE A 393
ALA A 405
VAL A 364
VAL A 396
 None
 0.88A 4nkvA-2pzdA:
undetectable		 4nkvA-2pzdA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2pzd SERINE PROTEASE
HTRA2
(Homo
sapiens) 		5 / 12 ILE A 413
ILE A 393
ALA A 405
VAL A 364
VAL A 396
 None
 0.88A 4nkvB-2pzdA:
undetectable		 4nkvB-2pzdA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2pzd SERINE PROTEASE
HTRA2
(Homo
sapiens) 		5 / 12 ILE A 413
ILE A 393
ALA A 405
VAL A 364
VAL A 396
 None
 0.87A 4nkxA-2pzdA:
undetectable		 4nkxA-2pzdA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W3J_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2pzd SERINE PROTEASE
HTRA2
(Homo
sapiens) 		4 / 8 VAL A 427
ASP A 426
GLN A 422
LEU A 369
 None
 0.93A 5w3jB-2pzdA:
undetectable		 5w3jB-2pzdA:
14.04