SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pzf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_0
(SUN PROTEIN)		 2pzf CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Homo
sapiens) 		5 / 12 GLY A 545
GLY A 544
ILE A 530
ASP A 529
ARG A 518
 None
 1.03A 1sqfA-2pzfA:
undetectable		 1sqfA-2pzfA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2pzf CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Homo
sapiens) 		4 / 6 ALA A 559
TYR A 517
ILE A 556
ILE A 521
 None
 1.25A 2dcfA-2pzfA:
undetectable		 2dcfA-2pzfA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_F_BEZF1222_0
(PEROXIREDOXIN 6.)		 2pzf CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Homo
sapiens) 		4 / 7 THR A 438
PRO A 439
VAL A 440
GLU A 621
 None
None
ATP  A   1 (-4.7A)
None
 1.04A 2v41E-2pzfA:
undetectable
2v41F-2pzfA:
undetectable		 2v41E-2pzfA:
20.75
2v41F-2pzfA:
20.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SI7_A_ACTA4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2pzf CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Homo
sapiens) 		4 / 4 LEU A 541
GLY A 542
GLY A 545
THR A 547
 None
 0.65A 3si7A-2pzfA:
30.9		 3si7A-2pzfA:
73.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_1
(HIV-1 PROTEASE)		 2pzf CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Homo
sapiens) 		4 / 7 LEU A 570
ALA A 566
ASP A 565
VAL A 562
 None
 0.74A 4eyrA-2pzfA:
undetectable		 4eyrA-2pzfA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_E_SAME501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2pzf CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Homo
sapiens) 		5 / 9 LEU A 619
HIS A 620
GLY A 461
SER A 624
LEU A 441
 None
None
ATP  A   1 (-3.5A)
None
None
 1.19A 5o96E-2pzfA:
undetectable
5o96F-2pzfA:
undetectable		 5o96E-2pzfA:
21.80
5o96F-2pzfA:
21.80