SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pzi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3003_1
(SERUM ALBUMIN)		 2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG
(Mycobacterium
tuberculosis) 		4 / 6 HIS A 159
ILE A 165
ALA A  91
VAL A 179
 None
AXX  A 753 ( 4.3A)
AXX  A 753 (-3.5A)
AXX  A 753 ( 4.6A)
 0.97A 1hk1A-2pziA:
3.2		 1hk1A-2pziA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 661
ALA A 664
ALA A 665
LEU A 704
ALA A 644
 None
 0.96A 1k74A-2pziA:
undetectable		 1k74A-2pziA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWF_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG
(Mycobacterium
tuberculosis) 		5 / 9 LEU A 141
VAL A 227
VAL A 217
GLY A 228
TYR A 166
 None
 1.36A 1lwfA-2pziA:
undetectable		 1lwfA-2pziA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4H_A_REAA500_1
(NUCLEAR RECEPTOR
ROR-BETA)		 2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG
(Mycobacterium
tuberculosis) 		5 / 11 ILE A 681
VAL A 668
ARG A 666
VAL A 623
ALA A 639
 None
 1.19A 1n4hA-2pziA:
undetectable		 1n4hA-2pziA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG1_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG
(Mycobacterium
tuberculosis) 		3 / 3 TRP A 540
VAL A 455
PRO A 456
 None
 0.65A 1rg1A-2pziA:
undetectable		 1rg1A-2pziA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH0_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG
(Mycobacterium
tuberculosis) 		3 / 3 TRP A 540
VAL A 455
PRO A 456
 None
 0.67A 1rh0A-2pziA:
undetectable		 1rh0A-2pziA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB8_0
(GRAMICIDIN A)		 2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG
(Mycobacterium
tuberculosis) 		4 / 5 VAL A 620
GLY A 621
VAL A 623
TRP A 596
 None
 1.14A 1tkqB-2pziA:
undetectable		 1tkqB-2pziA:
2.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 426
TYR A 592
THR A 579
LEU A 582
 None
 1.06A 1v54A-2pziA:
2.5
1v54J-2pziA:
undetectable		 1v54A-2pziA:
21.85
1v54J-2pziA:
6.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_B_9CRB202_1
(RXR-LIKE PROTEIN)		 2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 661
ALA A 664
ALA A 665
LEU A 704
ALA A 644
 None
 0.93A 1xiuB-2pziA:
undetectable		 1xiuB-2pziA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_A_9CRA801_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 661
ALA A 664
ALA A 665
LEU A 704
ALA A 644
 None
 0.91A 1xlsA-2pziA:
undetectable		 1xlsA-2pziA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_B_9CRB802_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 661
ALA A 664
ALA A 665
LEU A 704
ALA A 644
 None
 0.92A 1xlsB-2pziA:
undetectable		 1xlsB-2pziA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_C_9CRC803_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 661
ALA A 664
ALA A 665
LEU A 704
ALA A 644
 None
 0.92A 1xlsC-2pziA:
undetectable		 1xlsC-2pziA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_D_9CRD804_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 661
ALA A 664
ALA A 665
LEU A 704
ALA A 644
 None
 0.91A 1xlsD-2pziA:
undetectable		 1xlsD-2pziA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG
(Mycobacterium
tuberculosis) 		3 / 3 PHE A 214
ARG A 171
ASN A 172
 None
 0.92A 1xzxX-2pziA:
undetectable		 1xzxX-2pziA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_1
(PHOSPHOLIPASE A2
HOMOLOG 2)		 2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 516
LEU A 547
ARG A 542
TYR A 541
PRO A 456
 None
 1.23A 1y4lA-2pziA:
undetectable		 1y4lA-2pziA:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1502_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG
(Mycobacterium
tuberculosis) 		4 / 5 PRO A 310
GLY A 347
ASN A 346
GLY A 109
 None
 1.02A 1zlqA-2pziA:
undetectable		 1zlqA-2pziA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		 2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG
(Mycobacterium
tuberculosis) 		4 / 6 TYR A 552
GLY A 423
PHE A 422
ARG A 611
 None
 1.24A 2a3cB-2pziA:
undetectable		 2a3cB-2pziA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_B_SNLB503_2
(MINERALOCORTICOID
RECEPTOR)		 2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG
(Mycobacterium
tuberculosis) 		4 / 5 LEU A 261
LEU A 257
LEU A 289
LEU A 291
 None
 1.03A 2ab2B-2pziA:
undetectable		 2ab2B-2pziA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_E_REAE504_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG
(Mycobacterium
tuberculosis) 		5 / 11 ILE A 661
ALA A 664
ALA A 665
LEU A 704
ALA A 644
 None
 0.92A 2aclE-2pziA:
undetectable		 2aclE-2pziA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_G_REAG501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 661
ALA A 664
ALA A 665
LEU A 704
ALA A 644
 None
 0.89A 2aclG-2pziA:
undetectable		 2aclG-2pziA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2003_1
(SERUM ALBUMIN)		 2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG
(Mycobacterium
tuberculosis) 		5 / 9 LEU A 202
ARG A 199
PHE A 201
LEU A 267
ALA A 296
 None
 1.11A 2bxeA-2pziA:
2.4		 2bxeA-2pziA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2003_1
(SERUM ALBUMIN)		 2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG
(Mycobacterium
tuberculosis) 		5 / 10 LEU A 202
ARG A 199
PHE A 201
LEU A 267
ALA A 296
 None
 1.10A 2bxeB-2pziA:
undetectable		 2bxeB-2pziA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 426
TYR A 592
THR A 579
LEU A 582
 None
 1.05A 2dyrA-2pziA:
0.1
2dyrJ-2pziA:
undetectable		 2dyrA-2pziA:
21.85
2dyrJ-2pziA:
6.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_J_CHDJ101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 426
TYR A 592
THR A 579
LEU A 582
 None
 1.07A 2dysA-2pziA:
2.0
2dysJ-2pziA:
undetectable		 2dysA-2pziA:
21.85
2dysJ-2pziA:
6.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_W_CHDW101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 426
TYR A 592
THR A 579
LEU A 582
 None
 1.03A 2dysN-2pziA:
0.4
2dysW-2pziA:
undetectable		 2dysN-2pziA:
21.85
2dysW-2pziA:
6.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 426
TYR A 592
THR A 579
LEU A 582
 None
 1.07A 2eijA-2pziA:
0.4
2eijJ-2pziA:
undetectable		 2eijA-2pziA:
21.85
2eijJ-2pziA:
6.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG
(Mycobacterium
tuberculosis) 		4 / 7 LEU A 426
TYR A 592
THR A 579
LEU A 582
 None
 1.04A 2eikA-2pziA:
undetectable
2eikJ-2pziA:
undetectable		 2eikA-2pziA:
21.85
2eikJ-2pziA:
6.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 426
TYR A 592
THR A 579
LEU A 582
 None
 1.05A 2eilA-2pziA:
undetectable
2eilJ-2pziA:
undetectable		 2eilA-2pziA:
21.85
2eilJ-2pziA:
6.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UYQ_A_SAMA1311_0
(HYPOTHETICAL PROTEIN
ML2640)		 2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG
(Mycobacterium
tuberculosis) 		4 / 7 ALA A 622
ASP A 627
LEU A 626
ARG A 667
 None
 0.83A 2uyqA-2pziA:
undetectable		 2uyqA-2pziA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG
(Mycobacterium
tuberculosis) 		4 / 7 ALA A 571
ALA A 575
THR A 579
LEU A 547
 None
 0.87A 2wx2A-2pziA:
undetectable		 2wx2A-2pziA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_C_X2NC1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG
(Mycobacterium
tuberculosis) 		5 / 12 PHE A 415
VAL A 509
ALA A 571
ALA A 575
THR A 579
 None
 1.12A 2x2nC-2pziA:
undetectable		 2x2nC-2pziA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1414_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG
(Mycobacterium
tuberculosis) 		5 / 8 LEU A 353
ILE A 374
LEU A 370
THR A 339
LEU A 340
 None
 1.30A 2xfhA-2pziA:
undetectable		 2xfhA-2pziA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 426
TYR A 592
THR A 579
LEU A 582
 None
 1.09A 2zxwA-2pziA:
2.4
2zxwJ-2pziA:
undetectable		 2zxwA-2pziA:
21.85
2zxwJ-2pziA:
6.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 426
TYR A 592
THR A 579
LEU A 582
 None
 1.07A 3abmA-2pziA:
0.4
3abmJ-2pziA:
undetectable		 3abmA-2pziA:
21.85
3abmJ-2pziA:
6.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 426
TYR A 592
THR A 579
LEU A 582
 None
 1.04A 3asnA-2pziA:
0.4
3asnJ-2pziA:
undetectable		 3asnA-2pziA:
21.85
3asnJ-2pziA:
6.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 426
TYR A 592
THR A 579
LEU A 582
 None
 1.04A 3asoA-2pziA:
0.2
3asoJ-2pziA:
undetectable		 3asoA-2pziA:
21.85
3asoJ-2pziA:
6.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 574
GLY A 608
PHE A 591
VAL A 424
LEU A 626
 None
 1.30A 3dh0A-2pziA:
undetectable		 3dh0A-2pziA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)		 2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 687
GLY A 688
VAL A 685
LEU A 721
ILE A 703
 None
 1.21A 3h52B-2pziA:
undetectable		 3h52B-2pziA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_C_DX2C270_1
(PTERIDINE REDUCTASE
1)		 2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG
(Mycobacterium
tuberculosis) 		4 / 8 SER A 710
PHE A 708
VAL A 685
LEU A 704
 None
 1.12A 3jq7C-2pziA:
undetectable		 3jq7C-2pziA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KHM_A_TPFA501_1
(STEROL 14
ALPHA-DEMETHYLASE)		 2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG
(Mycobacterium
tuberculosis) 		4 / 8 ALA A 571
ALA A 575
THR A 579
LEU A 547
 None
 0.85A 3khmA-2pziA:
undetectable		 3khmA-2pziA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_A_TPFA490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG
(Mycobacterium
tuberculosis) 		4 / 8 ALA A 571
ALA A 575
THR A 579
LEU A 547
 None
 0.84A 3l4dA-2pziA:
undetectable		 3l4dA-2pziA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG801_0
(GLUTAMATE RECEPTOR 2)		 2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG
(Mycobacterium
tuberculosis) 		3 / 3 PRO A 134
SER A 186
ASN A 107
 None
 0.85A 3lslG-2pziA:
undetectable		 3lslG-2pziA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA1001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG
(Mycobacterium
tuberculosis) 		4 / 5 LEU A 704
GLY A 705
PHE A 706
ARG A 682
 None
 1.17A 3smtA-2pziA:
undetectable		 3smtA-2pziA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 282
LEU A 340
VAL A 399
LEU A 369
VAL A 395
 None
 1.08A 3w68B-2pziA:
undetectable		 3w68B-2pziA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 282
LEU A 340
VAL A 399
LEU A 369
VAL A 395
 None
 1.06A 3w68C-2pziA:
undetectable		 3w68C-2pziA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG
(Mycobacterium
tuberculosis) 		7 / 12 LYS A 181
ILE A 230
MET A 232
ASP A 276
LYS A 278
ASN A 281
ASP A 293
 AXX  A 753 ( 4.3A)
None
AXX  A 753 (-3.6A)
None
None
None
AXX  A 753 ( 4.4A)
 0.92A 4an2A-2pziA:
8.8		 4an2A-2pziA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG
(Mycobacterium
tuberculosis) 		7 / 12 LYS A 181
LEU A 202
ILE A 230
MET A 232
LYS A 278
ASN A 281
ASP A 293
 AXX  A 753 ( 4.3A)
None
None
AXX  A 753 (-3.6A)
None
None
AXX  A 753 ( 4.4A)
 1.03A 4an2A-2pziA:
8.8		 4an2A-2pziA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_A_CLQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 236
GLY A 237
ILE A 292
VAL A 178
ILE A 157
 AXX  A 753 ( 3.9A)
None
AXX  A 753 (-4.3A)
None
AXX  A 753 ( 4.1A)
 1.23A 4fglA-2pziA:
undetectable
4fglB-2pziA:
undetectable		 4fglA-2pziA:
15.54
4fglB-2pziA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_A_CP6A201_1
(DIHYDROFOLATE
REDUCTASE)		 2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG
(Mycobacterium
tuberculosis) 		5 / 10 ILE A 292
THR A 334
LEU A 338
ILE A 282
TYR A 274
 AXX  A 753 (-4.3A)
None
None
None
None
 1.07A 4km0A-2pziA:
undetectable		 4km0A-2pziA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_B_CP6B201_1
(DIHYDROFOLATE
REDUCTASE)		 2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 292
THR A 334
LEU A 338
ILE A 282
TYR A 274
 AXX  A 753 (-4.3A)
None
None
None
None
 1.05A 4km0B-2pziA:
undetectable		 4km0B-2pziA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG
(Mycobacterium
tuberculosis) 		6 / 12 LYS A 181
LEU A 202
ILE A 230
MET A 232
ASN A 281
ASP A 293
 AXX  A 753 ( 4.3A)
None
None
AXX  A 753 (-3.6A)
None
AXX  A 753 ( 4.4A)
 0.95A 4lmnA-2pziA:
14.0		 4lmnA-2pziA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA7_A_P2ZA301_1
(MAJOR PRION PROTEIN)		 2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG
(Mycobacterium
tuberculosis) 		4 / 8 VAL A 518
LEU A 513
TYR A 541
THR A 579
 None
 0.93A 4ma7A-2pziA:
undetectable		 4ma7A-2pziA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA603_1
(SERUM ALBUMIN)		 2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG
(Mycobacterium
tuberculosis) 		5 / 11 LEU A 483
ARG A 487
LEU A 506
LEU A 480
LEU A 468
 None
 1.42A 4or0A-2pziA:
2.4		 4or0A-2pziA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG
(Mycobacterium
tuberculosis) 		4 / 7 THR A 334
LEU A 335
THR A 330
LEU A 261
 None
 0.91A 4z91F-2pziA:
1.7
4z91G-2pziA:
1.8
4z91H-2pziA:
0.5
4z91I-2pziA:
1.9
4z91J-2pziA:
0.5		 4z91F-2pziA:
18.13
4z91G-2pziA:
18.13
4z91H-2pziA:
18.13
4z91I-2pziA:
18.13
4z91J-2pziA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 584
TYR A 552
GLU A 448
ALA A 555
SER A 604
 None
 1.08A 5igvA-2pziA:
6.6		 5igvA-2pziA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 400
LEU A 248
LEU A 289
ALA A 255
LEU A 396
 None
 1.32A 5iktB-2pziA:
undetectable		 5iktB-2pziA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG
(Mycobacterium
tuberculosis) 		3 / 3 ALA A 511
GLN A 475
THR A 479
 None
GOL  A 755 (-4.9A)
None
 0.66A 5n0oA-2pziA:
undetectable		 5n0oA-2pziA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_A_BEZA301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG
(Mycobacterium
tuberculosis) 		4 / 7 ILE A 260
LEU A 261
MET A 388
LEU A 392
 None
 0.92A 5u4sA-2pziA:
undetectable		 5u4sA-2pziA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_B_BEZB301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG
(Mycobacterium
tuberculosis) 		4 / 8 ILE A 260
LEU A 261
MET A 388
LEU A 392
 None
 0.90A 5u4sB-2pziA:
undetectable		 5u4sB-2pziA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 426
TYR A 592
THR A 579
LEU A 582
 None
 1.03A 5x1fA-2pziA:
0.3
5x1fJ-2pziA:
undetectable		 5x1fA-2pziA:
21.85
5x1fJ-2pziA:
6.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA503_1
(CYTOCHROME P450 2C9)		 2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG
(Mycobacterium
tuberculosis) 		4 / 5 PRO A 322
GLY A 321
THR A 320
ASN A 301
 None
 0.99A 5x23A-2pziA:
undetectable		 5x23A-2pziA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A60_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 661
ALA A 664
ALA A 665
LEU A 704
ALA A 644
 None
 0.99A 6a60D-2pziA:
undetectable		 6a60D-2pziA:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG
(Mycobacterium
tuberculosis) 		4 / 7 LEU A 426
TYR A 592
THR A 579
LEU A 582
 None
 0.94A 6nmpA-2pziA:
0.7
6nmpJ-2pziA:
undetectable		 6nmpA-2pziA:
21.85
6nmpJ-2pziA:
6.88