SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pzk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1872_0
(FPRA)		 2pzk PUTATIVE NUCLEOTIDE
SUGAR EPIMERASE/
DEHYDRATASE
(Bordetella
bronchiseptica) 		4 / 5 SER A 143
ASN A  92
ALA A  78
GLU A  87
 None
None
NAD  A 401 ( 4.5A)
None
 1.42A 1lqtA-2pzkA:
4.2
1lqtB-2pzkA:
4.0		 1lqtA-2pzkA:
20.68
1lqtB-2pzkA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1429_0
(FPRA)		 2pzk PUTATIVE NUCLEOTIDE
SUGAR EPIMERASE/
DEHYDRATASE
(Bordetella
bronchiseptica) 		4 / 5 SER A 143
ASN A  92
ALA A  78
GLU A  87
 None
None
NAD  A 401 ( 4.5A)
None
 1.39A 1lquA-2pzkA:
4.2
1lquB-2pzkA:
3.8		 1lquA-2pzkA:
20.68
1lquB-2pzkA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2001_1
(SERUM ALBUMIN)		 2pzk PUTATIVE NUCLEOTIDE
SUGAR EPIMERASE/
DEHYDRATASE
(Bordetella
bronchiseptica) 		4 / 8 ALA A  34
PHE A  33
ALA A   9
LEU A  41
 NAD  A 401 (-3.9A)
None
NAD  A 401 (-4.1A)
None
 0.94A 2bxmA-2pzkA:
undetectable		 2bxmA-2pzkA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_1
(ESTROGEN RECEPTOR)		 2pzk PUTATIVE NUCLEOTIDE
SUGAR EPIMERASE/
DEHYDRATASE
(Bordetella
bronchiseptica) 		5 / 12 MET A 201
ALA A 208
ASP A 209
LEU A 212
LEU A 112
 None
 1.08A 2jfaB-2pzkA:
undetectable		 2jfaB-2pzkA:
25.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1303_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2pzk PUTATIVE NUCLEOTIDE
SUGAR EPIMERASE/
DEHYDRATASE
(Bordetella
bronchiseptica) 		4 / 7 PRO A 133
ILE A 128
PRO A 136
GLY A 121
 None
 0.98A 2y7kA-2pzkA:
undetectable		 2y7kA-2pzkA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_C_DX4C270_0
(PTERIDINE REDUCTASE
1)		 2pzk PUTATIVE NUCLEOTIDE
SUGAR EPIMERASE/
DEHYDRATASE
(Bordetella
bronchiseptica) 		4 / 6 ARG A 110
SER A 160
PHE A 221
PRO A 217
 None
 1.35A 3jqaC-2pzkA:
16.3		 3jqaC-2pzkA:
28.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2pzk PUTATIVE NUCLEOTIDE
SUGAR EPIMERASE/
DEHYDRATASE
(Bordetella
bronchiseptica) 		4 / 7 GLY A 288
THR A 287
ILE A 286
THR A 225
 None
 0.92A 4acaC-2pzkA:
5.9		 4acaC-2pzkA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2pzk PUTATIVE NUCLEOTIDE
SUGAR EPIMERASE/
DEHYDRATASE
(Bordetella
bronchiseptica) 		5 / 12 MET A 201
PHE A 204
GLY A   8
SER A  75
ILE A   5
 None
None
None
NAD  A 401 (-3.2A)
None
 1.44A 4djeA-2pzkA:
undetectable		 4djeA-2pzkA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QCK_A_ASDA404_1
(3-KETOSTEROID-9-ALPH
A-MONOOXYGENASE
OXYGENASE SUBUNIT)		 2pzk PUTATIVE NUCLEOTIDE
SUGAR EPIMERASE/
DEHYDRATASE
(Bordetella
bronchiseptica) 		5 / 12 LEU A  28
ALA A 102
ASN A  98
GLY A  52
ASP A  56
 None
 1.23A 4qckA-2pzkA:
undetectable		 4qckA-2pzkA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_A_ADNA1002_1
(MYOSIN HEAVY CHAIN
KINASE A)		 2pzk PUTATIVE NUCLEOTIDE
SUGAR EPIMERASE/
DEHYDRATASE
(Bordetella
bronchiseptica) 		5 / 11 ALA A  76
LEU A 212
LEU A 111
LEU A 112
PHE A 114
 NAD  A 401 (-3.5A)
None
None
None
NAD  A 401 (-4.9A)
 1.13A 4zmeA-2pzkA:
undetectable		 4zmeA-2pzkA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_A_ADNA1002_1
(MYOSIN HEAVY CHAIN
KINASE A)		 2pzk PUTATIVE NUCLEOTIDE
SUGAR EPIMERASE/
DEHYDRATASE
(Bordetella
bronchiseptica) 		5 / 11 GLY A  10
LEU A 212
LEU A 111
LEU A 112
PHE A 114
 NAD  A 401 (-3.1A)
None
None
None
NAD  A 401 (-4.9A)
 1.09A 4zmeA-2pzkA:
undetectable		 4zmeA-2pzkA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_B_ADNB902_1
(MYOSIN HEAVY CHAIN
KINASE A)		 2pzk PUTATIVE NUCLEOTIDE
SUGAR EPIMERASE/
DEHYDRATASE
(Bordetella
bronchiseptica) 		5 / 10 ALA A  76
LEU A 212
LEU A 111
LEU A 112
PHE A 114
 NAD  A 401 (-3.5A)
None
None
None
NAD  A 401 (-4.9A)
 1.14A 4zmeB-2pzkA:
undetectable		 4zmeB-2pzkA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8D_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 2pzk PUTATIVE NUCLEOTIDE
SUGAR EPIMERASE/
DEHYDRATASE
(Bordetella
bronchiseptica) 		3 / 3 THR A 125
PRO A 129
ASP A 131
 None
 0.66A 5l8dB-2pzkA:
undetectable		 5l8dB-2pzkA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWU_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 2pzk PUTATIVE NUCLEOTIDE
SUGAR EPIMERASE/
DEHYDRATASE
(Bordetella
bronchiseptica) 		3 / 3 THR A 125
PRO A 129
ASP A 131
 None
 0.66A 5mwuB-2pzkA:
undetectable		 5mwuB-2pzkA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 2pzk PUTATIVE NUCLEOTIDE
SUGAR EPIMERASE/
DEHYDRATASE
(Bordetella
bronchiseptica) 		4 / 7 PHE A 114
ARG A 162
LEU A 161
ALA A 208
 NAD  A 401 (-4.9A)
None
None
None
 1.30A 6b89A-2pzkA:
undetectable		 6b89A-2pzkA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_2
(PROTEASE)		 2pzk PUTATIVE NUCLEOTIDE
SUGAR EPIMERASE/
DEHYDRATASE
(Bordetella
bronchiseptica) 		3 / 3 LEU A 111
ASP A 209
ILE A 207
 None
 0.56A 6dh0B-2pzkA:
undetectable		 6dh0B-2pzkA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 2pzk PUTATIVE NUCLEOTIDE
SUGAR EPIMERASE/
DEHYDRATASE
(Bordetella
bronchiseptica) 		3 / 3 ASN A  15
PRO A 169
GLN A 289
 None
 0.94A 6jnhA-2pzkA:
undetectable		 6jnhA-2pzkA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 2pzk PUTATIVE NUCLEOTIDE
SUGAR EPIMERASE/
DEHYDRATASE
(Bordetella
bronchiseptica) 		3 / 3 ASN A  15
PRO A 169
GLN A 289
 None
 0.93A 6jogA-2pzkA:
3.6		 6jogA-2pzkA:
19.81