SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2q04'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3004_0
(BETA-CARBONIC
ANHYDRASE)		 2q04 ACETOIN UTILIZATION
PROTEIN
(Exiguobacterium
sibiricum) 		4 / 6 GLN A   5
ASP A 122
VAL A 118
GLY A  22
 None
 1.14A 1ekjC-2q04A:
undetectable
1ekjD-2q04A:
undetectable		 1ekjC-2q04A:
18.78
1ekjD-2q04A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3007_0
(BETA-CARBONIC
ANHYDRASE)		 2q04 ACETOIN UTILIZATION
PROTEIN
(Exiguobacterium
sibiricum) 		4 / 6 ASP A 122
VAL A 118
GLY A  22
GLN A   5
 None
 1.17A 1ekjC-2q04A:
undetectable
1ekjD-2q04A:
undetectable		 1ekjC-2q04A:
18.78
1ekjD-2q04A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OT7_B_IU5B1002_1
(BILE ACID RECEPTOR)		 2q04 ACETOIN UTILIZATION
PROTEIN
(Exiguobacterium
sibiricum) 		5 / 12 LEU A 164
MET A 159
SER A 119
PHE A  77
ILE A 130
 None
 1.40A 1ot7B-2q04A:
undetectable		 1ot7B-2q04A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B9E_A_SAMA1201_0
(NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2)		 2q04 ACETOIN UTILIZATION
PROTEIN
(Exiguobacterium
sibiricum) 		5 / 12 PRO A  23
GLY A  22
ASN A   7
LEU A  78
ARG A  61
 None
 1.38A 2b9eA-2q04A:
undetectable		 2b9eA-2q04A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D20_A_017A201_1
(HIV-1 PROTEASE)		 2q04 ACETOIN UTILIZATION
PROTEIN
(Exiguobacterium
sibiricum) 		5 / 12 LEU A 115
GLY A  22
ASP A 122
GLY A  60
ILE A  54
 None
 0.98A 3d20A-2q04A:
undetectable		 3d20A-2q04A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_B_017B200_1
(PROTEASE)		 2q04 ACETOIN UTILIZATION
PROTEIN
(Exiguobacterium
sibiricum) 		5 / 9 LEU A 115
GLY A  22
ASP A 122
GLY A  60
ILE A  54
 None
 1.03A 3ektA-2q04A:
undetectable		 3ektA-2q04A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FGR_B_ACTB21_0
(PUTATIVE
PHOSPHOLIPASE B-LIKE
2 40 KDA FORM)		 2q04 ACETOIN UTILIZATION
PROTEIN
(Exiguobacterium
sibiricum) 		4 / 4 ARG A 105
ASP A  70
ASP A  35
PRO A  36
 None
 1.09A 3fgrB-2q04A:
undetectable		 3fgrB-2q04A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GGU_B_017B201_2
(PROTEASE)		 2q04 ACETOIN UTILIZATION
PROTEIN
(Exiguobacterium
sibiricum) 		5 / 9 LEU A 115
GLY A  22
ASP A 122
GLY A  60
ILE A  54
 None
 1.03A 3gguB-2q04A:
undetectable		 3gguB-2q04A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWM_B_017B402_1
(PROTEASE)		 2q04 ACETOIN UTILIZATION
PROTEIN
(Exiguobacterium
sibiricum) 		5 / 12 LEU A 115
GLY A  22
ASP A 122
GLY A  60
ILE A  54
 None
 1.03A 3pwmA-2q04A:
undetectable		 3pwmA-2q04A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 2q04 ACETOIN UTILIZATION
PROTEIN
(Exiguobacterium
sibiricum) 		4 / 6 GLY A  16
PRO A  17
LEU A  11
VAL A  18
 None
 0.87A 4dubB-2q04A:
undetectable		 4dubB-2q04A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_A_PQNA846_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 2q04 ACETOIN UTILIZATION
PROTEIN
(Exiguobacterium
sibiricum) 		5 / 10 MET A 125
ALA A 184
LEU A 164
GLY A 163
ALA A  40
 None
None
None
None
EDO  A 214 (-3.6A)
 1.06A 4fe1A-2q04A:
undetectable
4fe1J-2q04A:
undetectable		 4fe1A-2q04A:
14.04
4fe1J-2q04A:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_1_PQN12001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 2q04 ACETOIN UTILIZATION
PROTEIN
(Exiguobacterium
sibiricum) 		5 / 11 GLY A 187
ALA A 184
LEU A 164
GLY A 163
ALA A  40
 None
None
None
None
EDO  A 214 (-3.6A)
 1.05A 4l6v1-2q04A:
undetectable
4l6v6-2q04A:
undetectable		 4l6v1-2q04A:
12.88
4l6v6-2q04A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_1_PQN12001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 2q04 ACETOIN UTILIZATION
PROTEIN
(Exiguobacterium
sibiricum) 		5 / 11 MET A 125
ALA A 184
LEU A 164
GLY A 163
ALA A  40
 None
None
None
None
EDO  A 214 (-3.6A)
 1.05A 4l6v1-2q04A:
undetectable
4l6v6-2q04A:
undetectable		 4l6v1-2q04A:
12.88
4l6v6-2q04A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 2q04 ACETOIN UTILIZATION
PROTEIN
(Exiguobacterium
sibiricum) 		5 / 9 MET A 125
ALA A 184
LEU A 164
GLY A 162
ALA A  40
 None
None
None
None
EDO  A 214 (-3.6A)
 1.50A 4l6va-2q04A:
undetectable
4l6vf-2q04A:
undetectable		 4l6va-2q04A:
12.88
4l6vf-2q04A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 2q04 ACETOIN UTILIZATION
PROTEIN
(Exiguobacterium
sibiricum) 		5 / 9 MET A 125
ALA A 184
LEU A 164
GLY A 163
ALA A  40
 None
None
None
None
EDO  A 214 (-3.6A)
 1.15A 4l6va-2q04A:
undetectable
4l6vf-2q04A:
undetectable		 4l6va-2q04A:
12.88
4l6vf-2q04A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2q04 ACETOIN UTILIZATION
PROTEIN
(Exiguobacterium
sibiricum) 		4 / 8 ILE A  72
LEU A 116
LEU A  11
PHE A 106
 None
 0.95A 4r38B-2q04A:
undetectable		 4r38B-2q04A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_2
(PROTEASE E35D-APV)		 2q04 ACETOIN UTILIZATION
PROTEIN
(Exiguobacterium
sibiricum) 		5 / 9 LEU A 115
GLY A  22
ASP A 122
GLY A  60
ILE A  54
 None
 1.04A 5kr0B-2q04A:
undetectable		 5kr0B-2q04A:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_C_08JC602_1
(CYTOCHROME P450 3A4)		 2q04 ACETOIN UTILIZATION
PROTEIN
(Exiguobacterium
sibiricum) 		4 / 7 LEU A  97
ALA A  99
ILE A  54
LEU A  78
 None
CA  A 211 ( 4.8A)
None
None
 0.82A 5te8C-2q04A:
undetectable		 5te8C-2q04A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB503_0
(AMINE OXIDASE LKCE)		 2q04 ACETOIN UTILIZATION
PROTEIN
(Exiguobacterium
sibiricum) 		3 / 3 VAL A  18
GLU A  19
ILE A  72
 None
 0.66A 6f7lB-2q04A:
undetectable		 6f7lB-2q04A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HQB_A_PQNA2001_0
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 2q04 ACETOIN UTILIZATION
PROTEIN
(Exiguobacterium
sibiricum) 		5 / 10 MET A 125
ALA A 184
LEU A 164
GLY A 163
LEU A  38
 None
 1.39A 6hqbA-2q04A:
undetectable
6hqbJ-2q04A:
undetectable		 6hqbA-2q04A:
17.96
6hqbJ-2q04A:
14.53