SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2q0f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_A_KANA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 2q0f RNA URIDYLYL
TRANSFERASE
(Trypanosoma
brucei) 		4 / 8 ASP A  68
GLY A 144
THR A 120
ASP A 136
 MG  A 401 (-2.6A)
UTP  A 501 (-3.6A)
None
U5P  A 502 (-4.0A)
 0.78A 1m4iA-2q0fA:
undetectable		 1m4iA-2q0fA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_B_SAMB302_0
(RRNA
METHYLTRANSFERASE)		 2q0f RNA URIDYLYL
TRANSFERASE
(Trypanosoma
brucei) 		5 / 10 ARG A 170
GLY A 238
GLY A 234
ILE A 332
ALA A 328
 None
 1.14A 1x7pA-2q0fA:
undetectable
1x7pB-2q0fA:
undetectable		 1x7pA-2q0fA:
23.50
1x7pB-2q0fA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_B_LDPB502_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 2q0f RNA URIDYLYL
TRANSFERASE
(Trypanosoma
brucei) 		4 / 5 GLN A 257
PHE A 252
PHE A 248
TRP A 293
 None
 1.36A 2qmzA-2q0fA:
undetectable
2qmzB-2q0fA:
undetectable		 2qmzA-2q0fA:
21.92
2qmzB-2q0fA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_B_TOPB1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 2q0f RNA URIDYLYL
TRANSFERASE
(Trypanosoma
brucei) 		5 / 11 ILE A 295
LEU A 321
LEU A 177
ILE A 186
ILE A 168
 None
 1.05A 2w9sB-2q0fA:
undetectable		 2w9sB-2q0fA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHT_A_SAMA200_0
(S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE)		 2q0f RNA URIDYLYL
TRANSFERASE
(Trypanosoma
brucei) 		5 / 12 GLY A 238
GLY A 234
ARG A  10
ILE A 168
LEU A 329
 None
 0.86A 3ihtA-2q0fA:
undetectable		 3ihtA-2q0fA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE202_1
(PROTEIN S100-A4)		 2q0f RNA URIDYLYL
TRANSFERASE
(Trypanosoma
brucei) 		5 / 11 ASP A  84
PHE A  52
LEU A  49
PHE A  69
ILE A 137
 None
U5P  A 502 ( 4.4A)
None
None
None
 1.46A 3ko0C-2q0fA:
undetectable
3ko0D-2q0fA:
undetectable
3ko0E-2q0fA:
0.0
3ko0F-2q0fA:
undetectable		 3ko0C-2q0fA:
13.66
3ko0D-2q0fA:
13.66
3ko0E-2q0fA:
13.66
3ko0F-2q0fA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO202_1
(PROTEIN S100-A4)		 2q0f RNA URIDYLYL
TRANSFERASE
(Trypanosoma
brucei) 		5 / 11 LEU A  49
PHE A  69
ILE A 137
PHE A  52
ASP A  84
 None
None
None
U5P  A 502 ( 4.4A)
None
 1.50A 3ko0O-2q0fA:
undetectable
3ko0P-2q0fA:
undetectable
3ko0Q-2q0fA:
0.0
3ko0R-2q0fA:
0.0		 3ko0O-2q0fA:
13.66
3ko0P-2q0fA:
13.66
3ko0Q-2q0fA:
13.66
3ko0R-2q0fA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT202_1
(PROTEIN S100-A4)		 2q0f RNA URIDYLYL
TRANSFERASE
(Trypanosoma
brucei) 		5 / 11 ASP A  84
PHE A  52
LEU A  49
PHE A  69
ILE A 137
 None
U5P  A 502 ( 4.4A)
None
None
None
 1.47A 3ko0Q-2q0fA:
0.0
3ko0R-2q0fA:
0.0
3ko0S-2q0fA:
undetectable
3ko0T-2q0fA:
undetectable		 3ko0Q-2q0fA:
13.66
3ko0R-2q0fA:
13.66
3ko0S-2q0fA:
13.66
3ko0T-2q0fA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		 2q0f RNA URIDYLYL
TRANSFERASE
(Trypanosoma
brucei) 		4 / 7 ASP A 243
GLN A 240
GLN A 201
GLU A 251
 None
 1.09A 3l2vA-2q0fA:
undetectable		 3l2vA-2q0fA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_C_AG2C1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 2q0f RNA URIDYLYL
TRANSFERASE
(Trypanosoma
brucei) 		4 / 8 HIS A  61
SER A  65
ASP A  68
ASP A 136
 None
UTP  A 501 (-2.6A)
MG  A 401 (-2.6A)
U5P  A 502 (-4.0A)
 1.01A 3n2oC-2q0fA:
undetectable
3n2oD-2q0fA:
undetectable		 3n2oC-2q0fA:
21.08
3n2oD-2q0fA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_A_ADNA353_1
(ADENOSINE KINASE)		 2q0f RNA URIDYLYL
TRANSFERASE
(Trypanosoma
brucei) 		5 / 12 ASN A 178
GLY A 183
GLY A 184
SER A 185
THR A 175
 UTP  A 501 ( 4.9A)
None
None
None
None
 1.00A 3uboA-2q0fA:
undetectable		 3uboA-2q0fA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		 2q0f RNA URIDYLYL
TRANSFERASE
(Trypanosoma
brucei) 		5 / 10 LEU A 321
THR A 175
GLY A 176
GLY A 184
SER A 185
 None
 1.22A 4bwlC-2q0fA:
undetectable		 4bwlC-2q0fA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 2q0f RNA URIDYLYL
TRANSFERASE
(Trypanosoma
brucei) 		4 / 7 THR A 239
ASN A 158
GLN A 206
LEU A 205
 None
 1.13A 4ib4A-2q0fA:
undetectable		 4ib4A-2q0fA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_A_IPHA101_0
(INSULIN)		 2q0f RNA URIDYLYL
TRANSFERASE
(Trypanosoma
brucei) 		5 / 10 HIS A 320
LEU A 321
ALA A 324
LEU A 177
LEU A 329
 None
 1.09A 4p65A-2q0fA:
undetectable
4p65B-2q0fA:
undetectable
4p65F-2q0fA:
undetectable
4p65H-2q0fA:
undetectable		 4p65A-2q0fA:
5.48
4p65B-2q0fA:
6.34
4p65F-2q0fA:
6.34
4p65H-2q0fA:
6.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_A_IPHA101_0
(INSULIN)		 2q0f RNA URIDYLYL
TRANSFERASE
(Trypanosoma
brucei) 		5 / 10 LEU A 245
HIS A 320
ALA A 324
LEU A 177
LEU A 329
 None
 1.18A 4p65A-2q0fA:
undetectable
4p65B-2q0fA:
undetectable
4p65F-2q0fA:
undetectable
4p65H-2q0fA:
undetectable		 4p65A-2q0fA:
5.48
4p65B-2q0fA:
6.34
4p65F-2q0fA:
6.34
4p65H-2q0fA:
6.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_C_IPHC101_0
(INSULIN)		 2q0f RNA URIDYLYL
TRANSFERASE
(Trypanosoma
brucei) 		5 / 11 HIS A 320
LEU A 321
ALA A 324
LEU A 329
LEU A 177
 None
 1.04A 4p65C-2q0fA:
undetectable
4p65D-2q0fA:
undetectable
4p65J-2q0fA:
undetectable
4p65L-2q0fA:
undetectable		 4p65C-2q0fA:
5.48
4p65D-2q0fA:
6.34
4p65J-2q0fA:
6.34
4p65L-2q0fA:
6.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_C_IPHC101_0
(INSULIN)		 2q0f RNA URIDYLYL
TRANSFERASE
(Trypanosoma
brucei) 		5 / 11 LEU A 245
HIS A 320
ALA A 324
LEU A 329
LEU A 177
 None
 1.13A 4p65C-2q0fA:
undetectable
4p65D-2q0fA:
undetectable
4p65J-2q0fA:
undetectable
4p65L-2q0fA:
undetectable		 4p65C-2q0fA:
5.48
4p65D-2q0fA:
6.34
4p65J-2q0fA:
6.34
4p65L-2q0fA:
6.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_G_IPHG101_0
(INSULIN)		 2q0f RNA URIDYLYL
TRANSFERASE
(Trypanosoma
brucei) 		5 / 11 LEU A 329
LEU A 177
HIS A 320
LEU A 321
ALA A 324
 None
 1.01A 4p65B-2q0fA:
undetectable
4p65D-2q0fA:
undetectable
4p65G-2q0fA:
undetectable
4p65H-2q0fA:
undetectable		 4p65B-2q0fA:
6.34
4p65D-2q0fA:
6.34
4p65G-2q0fA:
5.48
4p65H-2q0fA:
6.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_G_IPHG101_0
(INSULIN)		 2q0f RNA URIDYLYL
TRANSFERASE
(Trypanosoma
brucei) 		5 / 11 LEU A 329
LEU A 177
LEU A 245
HIS A 320
ALA A 324
 None
 1.08A 4p65B-2q0fA:
undetectable
4p65D-2q0fA:
undetectable
4p65G-2q0fA:
undetectable
4p65H-2q0fA:
undetectable		 4p65B-2q0fA:
6.34
4p65D-2q0fA:
6.34
4p65G-2q0fA:
5.48
4p65H-2q0fA:
6.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2q0f RNA URIDYLYL
TRANSFERASE
(Trypanosoma
brucei) 		4 / 8 PRO A 298
LEU A 193
VAL A  57
TYR A 154
 None
 1.03A 4pwdA-2q0fA:
3.4		 4pwdA-2q0fA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 2q0f RNA URIDYLYL
TRANSFERASE
(Trypanosoma
brucei) 		5 / 12 GLY A 184
GLY A 176
ILE A 182
ILE A 186
ALA A 179
 None
 1.15A 4qtuB-2q0fA:
undetectable		 4qtuB-2q0fA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 2q0f RNA URIDYLYL
TRANSFERASE
(Trypanosoma
brucei) 		5 / 12 GLY A 184
GLY A 176
ILE A 182
ILE A 186
ALA A 179
 None
 1.14A 4qtuD-2q0fA:
undetectable		 4qtuD-2q0fA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2q0f RNA URIDYLYL
TRANSFERASE
(Trypanosoma
brucei) 		4 / 5 ALA A 153
TYR A 154
PRO A 298
PHE A 207
 None
 1.33A 4ze2A-2q0fA:
undetectable		 4ze2A-2q0fA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_3
(PROTEASE)		 2q0f RNA URIDYLYL
TRANSFERASE
(Trypanosoma
brucei) 		3 / 3 ASP A  44
VAL A  71
LEU A 101
 None
 0.63A 5e5jB-2q0fA:
undetectable		 5e5jB-2q0fA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WM2_A_SALA601_1
(SALICYLATE-AMP
LIGASE)		 2q0f RNA URIDYLYL
TRANSFERASE
(Trypanosoma
brucei) 		5 / 9 ASN A 158
PHE A 155
CYH A 161
VAL A 195
LEU A 199
 None
 1.44A 5wm2A-2q0fA:
2.0		 5wm2A-2q0fA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 2q0f RNA URIDYLYL
TRANSFERASE
(Trypanosoma
brucei) 		4 / 6 TRP A 171
GLY A   9
ALA A 328
LEU A 329
 None
 0.90A 6fosA-2q0fA:
undetectable		 6fosA-2q0fA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_B_ACTB403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 2q0f RNA URIDYLYL
TRANSFERASE
(Trypanosoma
brucei) 		3 / 3 PHE A 247
ARG A 202
GLN A 201
 None
 1.09A 6g1pB-2q0fA:
undetectable		 6g1pB-2q0fA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 2q0f RNA URIDYLYL
TRANSFERASE
(Trypanosoma
brucei) 		5 / 10 VAL A  67
GLY A  53
SER A 148
ALA A 149
VAL A  70
 None
UTP  A 501 (-3.6A)
UTP  A 501 (-3.3A)
None
None
 1.49A 6hu9L-2q0fA:
undetectable
6hu9P-2q0fA:
undetectable
6hu9T-2q0fA:
undetectable		 6hu9L-2q0fA:
22.00
6hu9P-2q0fA:
20.42
6hu9T-2q0fA:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUP_B_DZPB502_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT BETA-3)		 2q0f RNA URIDYLYL
TRANSFERASE
(Trypanosoma
brucei) 		5 / 11 ILE A  97
LEU A  93
THR A  75
ASN A  73
LEU A  72
 None
 1.47A 6hupA-2q0fA:
undetectable
6hupB-2q0fA:
undetectable		 6hupA-2q0fA:
12.50
6hupB-2q0fA:
14.10