SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2q0l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Y_B_MK1B524_1
(PROTEIN (PROTEASE))		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 11 ALA A   5
VAL A  84
ILE A 108
GLY A   8
ILE A  93
 None
None
None
FAD  A 400 (-3.2A)
None
 0.81A 1c6yA-2q0lA:
undetectable		 1c6yA-2q0lA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Y_B_MK1B524_2
(PROTEIN (PROTEASE))		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 12 ALA A   5
VAL A  84
ILE A 108
GLY A   8
ILE A  93
 None
None
None
FAD  A 400 (-3.2A)
None
 0.83A 1c6yB-2q0lA:
undetectable		 1c6yB-2q0lA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Z_B_ROCB505_1
(PROTEIN (PROTEASE))		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 12 ALA A   5
VAL A  84
ILE A 108
GLY A   8
ILE A  93
 None
None
None
FAD  A 400 (-3.2A)
None
 0.82A 1c6zA-2q0lA:
undetectable		 1c6zA-2q0lA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Z_B_ROCB505_2
(PROTEIN (PROTEASE))		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 12 ALA A   5
VAL A  84
ILE A 108
GLY A   8
ILE A  93
 None
None
None
FAD  A 400 (-3.2A)
None
 0.78A 1c6zB-2q0lA:
undetectable		 1c6zB-2q0lA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_1
(HIV-1 PROTEASE)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 10 ALA A   5
VAL A  84
ILE A 108
GLY A   8
ILE A  93
 None
None
None
FAD  A 400 (-3.2A)
None
 0.81A 1hsgA-2q0lA:
undetectable		 1hsgA-2q0lA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_2
(HIV-1 PROTEASE)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 12 ALA A   5
VAL A  84
ILE A 108
GLY A   8
ILE A  93
 None
None
None
FAD  A 400 (-3.2A)
None
 0.81A 1hsgB-2q0lA:
undetectable		 1hsgB-2q0lA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_1
(HIV-1 PROTEASE)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 12 ALA A   5
VAL A  84
ILE A 108
GLY A   8
ILE A  93
 None
None
None
FAD  A 400 (-3.2A)
None
 0.83A 1hxbA-2q0lA:
undetectable		 1hxbA-2q0lA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_3
(HIV-1 PROTEASE)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 12 ALA A   5
VAL A  84
ILE A 108
GLY A   8
ILE A  93
 None
None
None
FAD  A 400 (-3.2A)
None
 0.76A 1hxbB-2q0lA:
undetectable		 1hxbB-2q0lA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_0
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 12 GLY A 280
ALA A 293
ALA A 278
ASP A 281
ILE A 282
 FAD  A 400 (-3.3A)
FAD  A 400 (-3.6A)
None
FAD  A 400 (-2.7A)
None
 1.18A 1nt2A-2q0lA:
undetectable		 1nt2A-2q0lA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDT_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 12 ALA A   5
VAL A  84
ILE A 108
GLY A   8
ILE A  93
 None
None
None
FAD  A 400 (-3.2A)
None
 0.90A 1sdtB-2q0lA:
undetectable		 1sdtB-2q0lA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		4 / 6 ARG A 175
ARG A 179
GLY A 152
HIS A 173
 NAP  A 401 (-3.8A)
NAP  A 401 (-3.9A)
NAP  A 401 (-3.4A)
NAP  A 401 (-4.1A)
 0.98A 1wmqA-2q0lA:
undetectable		 1wmqA-2q0lA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		4 / 6 ARG A 175
ARG A 179
GLY A 152
HIS A 173
 NAP  A 401 (-3.8A)
NAP  A 401 (-3.9A)
NAP  A 401 (-3.4A)
NAP  A 401 (-4.1A)
 0.98A 1wmqB-2q0lA:
undetectable		 1wmqB-2q0lA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		4 / 6 ARG A 175
ARG A 179
GLY A 152
HIS A 173
 NAP  A 401 (-3.8A)
NAP  A 401 (-3.9A)
NAP  A 401 (-3.4A)
NAP  A 401 (-4.1A)
 0.99A 1wpuA-2q0lA:
undetectable		 1wpuA-2q0lA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		4 / 6 ARG A 175
ARG A 179
GLY A 152
HIS A 173
 NAP  A 401 (-3.8A)
NAP  A 401 (-3.9A)
NAP  A 401 (-3.4A)
NAP  A 401 (-4.1A)
 0.99A 1wpuB-2q0lA:
undetectable		 1wpuB-2q0lA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		4 / 6 ARG A 175
ARG A 179
GLY A 152
HIS A 173
 NAP  A 401 (-3.8A)
NAP  A 401 (-3.9A)
NAP  A 401 (-3.4A)
NAP  A 401 (-4.1A)
 0.99A 1wrqB-2q0lA:
undetectable		 1wrqB-2q0lA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_2
(POL POLYPROTEIN)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 12 ALA A   5
VAL A  84
ILE A 108
GLY A   8
ILE A  93
 None
None
None
FAD  A 400 (-3.2A)
None
 0.82A 2avoB-2q0lA:
undetectable		 2avoB-2q0lA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVS_B_MK1B902_1
(POL POLYPROTEIN)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 12 ALA A   5
VAL A  84
ILE A 108
GLY A   8
ILE A  93
 None
None
None
FAD  A 400 (-3.2A)
None
 0.82A 2avsA-2q0lA:
undetectable		 2avsA-2q0lA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVS_B_MK1B902_3
(POL POLYPROTEIN)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 12 ALA A   5
VAL A  84
ILE A 108
GLY A   8
ILE A  93
 None
None
None
FAD  A 400 (-3.2A)
None
 0.84A 2avsB-2q0lA:
undetectable		 2avsB-2q0lA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_1
(POL POLYPROTEIN)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 12 GLY A  17
ALA A  16
GLY A  10
GLY A   9
ILE A 107
 None
None
FAD  A 400 (-3.4A)
FAD  A 400 (-4.5A)
None
 0.78A 2avvA-2q0lA:
undetectable		 2avvA-2q0lA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_3
(POL POLYPROTEIN)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 12 ALA A   5
VAL A  84
ILE A 108
GLY A   8
ILE A  93
 None
None
None
FAD  A 400 (-3.2A)
None
 0.73A 2avvB-2q0lA:
undetectable		 2avvB-2q0lA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_1
(POL POLYPROTEIN)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 12 ALA A   5
VAL A  84
ILE A 108
GLY A   8
ILE A  93
 None
None
None
FAD  A 400 (-3.2A)
None
 0.80A 2avvD-2q0lA:
undetectable		 2avvD-2q0lA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BPX_B_MK1B902_2
(HIV-1 PROTEASE)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 12 ALA A   5
VAL A  84
ILE A 108
GLY A   8
ILE A  93
 None
None
None
FAD  A 400 (-3.2A)
None
 0.83A 2bpxB-2q0lA:
undetectable		 2bpxB-2q0lA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8G_B_017B401_2
(POL POLYPROTEIN)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 12 ALA A   5
VAL A  84
ILE A 108
GLY A   8
ILE A  93
 None
None
None
FAD  A 400 (-3.2A)
None
 0.91A 2f8gB-2q0lA:
undetectable		 2f8gB-2q0lA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXE_A_DR7A102_1
(POL PROTEIN)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 12 GLY A  17
ALA A  16
GLY A  10
GLY A   9
ILE A 107
 None
None
FAD  A 400 (-3.4A)
FAD  A 400 (-4.5A)
None
 0.81A 2fxeA-2q0lA:
undetectable		 2fxeA-2q0lA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACTA544_0
(ACETYLCHOLINESTERASE)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 8 GLY A 150
GLY A 151
ALA A 155
PHE A 196
PHE A 178
 NAP  A 401 ( 4.0A)
NAP  A 401 (-3.1A)
None
None
None
 1.12A 2ha4A-2q0lA:
undetectable		 2ha4A-2q0lA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_3
(PROTEASE)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 12 ALA A   5
ILE A 108
GLY A   8
ALA A  95
ILE A  93
 None
None
FAD  A 400 (-3.2A)
None
None
 0.87A 2nmzB-2q0lA:
undetectable		 2nmzB-2q0lA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4K_A_DR7A301_2
(PROTEASE)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 12 ALA A   5
VAL A  84
ILE A 108
GLY A   8
ILE A  93
 None
None
None
FAD  A 400 (-3.2A)
None
 0.79A 2o4kB-2q0lA:
undetectable		 2o4kB-2q0lA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4L_A_TPVA403_2
(PROTEASE)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 12 ALA A   5
VAL A  84
ILE A 108
GLY A   8
ILE A  93
 None
None
None
FAD  A 400 (-3.2A)
None
 0.84A 2o4lB-2q0lA:
undetectable		 2o4lB-2q0lA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 12 ALA A   5
VAL A  84
ILE A 108
GLY A   8
ILE A  93
 None
None
None
FAD  A 400 (-3.2A)
None
 0.87A 2q63A-2q0lA:
undetectable		 2q63A-2q0lA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_1
(PROTEASE RETROPEPSIN)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 12 ALA A   5
VAL A  84
ILE A 108
GLY A   8
ILE A  93
 None
None
None
FAD  A 400 (-3.2A)
None
 0.78A 2q64A-2q0lA:
undetectable		 2q64A-2q0lA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_3
(PROTEASE RETROPEPSIN)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 12 ALA A   5
VAL A  84
ILE A 108
GLY A   8
ILE A  93
 None
None
None
FAD  A 400 (-3.2A)
None
 0.79A 2q64B-2q0lA:
undetectable		 2q64B-2q0lA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 12 ALA A   5
VAL A  84
ILE A 108
GLY A   8
ILE A  93
 None
None
None
FAD  A 400 (-3.2A)
None
 0.78A 2qakA-2q0lA:
undetectable		 2qakA-2q0lA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_1
(PROTEASE
(RETROPEPSIN))		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 12 ALA A   5
VAL A  84
ILE A 108
GLY A   8
ILE A  93
 None
None
None
FAD  A 400 (-3.2A)
None
 0.80A 3bvbA-2q0lA:
undetectable		 3bvbA-2q0lA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_3
(HIV-1 PROTEASE)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 12 GLY A  17
ALA A  16
GLY A  10
GLY A   9
ILE A 107
 None
None
FAD  A 400 (-3.4A)
FAD  A 400 (-4.5A)
None
 0.82A 3cyxB-2q0lA:
undetectable		 3cyxB-2q0lA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Z_B_017B201_1
(HIV-1 PROTEASE)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 12 ALA A   5
VAL A  84
ILE A 108
GLY A   8
ILE A  93
 None
None
None
FAD  A 400 (-3.2A)
None
 0.85A 3d1zA-2q0lA:
undetectable		 3d1zA-2q0lA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_C_478C200_2
(PROTEASE)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 10 ALA A   5
VAL A  84
ILE A 108
GLY A   8
ILE A  93
 None
None
None
FAD  A 400 (-3.2A)
None
 0.86A 3ekpD-2q0lA:
undetectable		 3ekpD-2q0lA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKX_B_1UNB201_2
(PROTEASE)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 11 ALA A   5
VAL A  84
ILE A 108
GLY A   8
ILE A  93
 None
None
None
FAD  A 400 (-3.2A)
None
 0.78A 3ekxB-2q0lA:
undetectable		 3ekxB-2q0lA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL1_A_DR7A100_2
(PROTEASE)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 12 ALA A   5
VAL A  84
ILE A 108
GLY A   8
ILE A  93
 None
None
None
FAD  A 400 (-3.2A)
None
 0.79A 3el1B-2q0lA:
undetectable		 3el1B-2q0lA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_2
(PROTEASE)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 10 ALA A   5
VAL A  84
ILE A 108
GLY A   8
ILE A  93
 None
None
None
FAD  A 400 (-3.2A)
None
 0.78A 3em3B-2q0lA:
undetectable		 3em3B-2q0lA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_2
(PROTEASE)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 12 ALA A   5
VAL A  84
ILE A 108
GLY A   8
ILE A  93
 None
None
None
FAD  A 400 (-3.2A)
None
 0.88A 3em6B-2q0lA:
undetectable		 3em6B-2q0lA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IIZ_A_SAMA1501_0
(BIOTIN SYNTHETASE,
PUTATIVE)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 12 CYH A 166
SER A 131
GLY A 129
ILE A 194
LEU A 162
 None
FAD  A 400 ( 4.0A)
None
None
None
 1.42A 3iizA-2q0lA:
undetectable		 3iizA-2q0lA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW2_A_017A401_2
(GAG-POL POLYPROTEIN)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 12 ALA A   5
VAL A  84
ILE A 108
GLY A   8
ILE A  93
 None
None
None
FAD  A 400 (-3.2A)
None
 0.83A 3jw2B-2q0lA:
undetectable		 3jw2B-2q0lA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_3
(HIV-1 PROTEASE)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 12 ALA A   5
VAL A  84
ILE A 108
GLY A   8
ILE A  93
 None
None
None
FAD  A 400 (-3.2A)
None
 0.76A 3k4vB-2q0lA:
undetectable		 3k4vB-2q0lA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_1
(HIV-1 PROTEASE)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 12 ALA A   5
VAL A  84
ILE A 108
GLY A   8
ILE A  93
 None
None
None
FAD  A 400 (-3.2A)
None
 0.80A 3k4vC-2q0lA:
undetectable		 3k4vC-2q0lA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_1
(GENOME POLYPROTEIN)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 12 ASP A 281
GLY A  37
ALA A 293
ALA A 294
ASP A 296
 FAD  A 400 (-2.7A)
None
FAD  A 400 (-3.6A)
None
None
 1.05A 3keeD-2q0lA:
undetectable		 3keeD-2q0lA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_2
(HIV-1 PROTEASE)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 11 ALA A   5
VAL A  84
ILE A 108
GLY A   8
ILE A  93
 None
None
None
FAD  A 400 (-3.2A)
None
 0.93A 3lzvB-2q0lA:
undetectable		 3lzvB-2q0lA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MWS_B_017B201_2
(HIV-1 PROTEASE)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 12 ALA A   5
VAL A  84
ILE A 108
GLY A   8
ILE A  93
 None
None
None
FAD  A 400 (-3.2A)
None
 0.80A 3mwsB-2q0lA:
undetectable		 3mwsB-2q0lA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU5_B_478B401_1
(PROTEASE)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 12 ALA A   5
VAL A  84
ILE A 108
GLY A   8
ILE A  93
 None
None
None
FAD  A 400 (-3.2A)
None
 0.89A 3nu5A-2q0lA:
undetectable		 3nu5A-2q0lA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU5_B_478B401_2
(PROTEASE)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 12 ALA A   5
VAL A  84
ILE A 108
GLY A   8
ILE A  93
 None
None
None
FAD  A 400 (-3.2A)
None
 0.86A 3nu5B-2q0lA:
undetectable		 3nu5B-2q0lA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_1
(PROTEASE)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 10 ALA A   5
VAL A  84
ILE A 108
GLY A   8
ILE A  93
 None
None
None
FAD  A 400 (-3.2A)
None
 0.87A 3nu6A-2q0lA:
undetectable		 3nu6A-2q0lA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_1
(PROTEASE)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 10 ALA A   5
VAL A  84
ILE A 108
GLY A   8
ILE A  93
 None
None
None
FAD  A 400 (-3.2A)
None
 0.90A 3nujA-2q0lA:
undetectable		 3nujA-2q0lA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_1
(PROTEASE)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 12 ALA A   5
VAL A  84
ILE A 108
GLY A   8
ILE A  93
 None
None
None
FAD  A 400 (-3.2A)
None
 0.76A 3oxcA-2q0lA:
undetectable		 3oxcA-2q0lA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_2
(HIV-1 PROTEASE)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 10 ALA A   5
VAL A  84
ILE A 108
GLY A   8
ILE A  93
 None
None
None
FAD  A 400 (-3.2A)
None
 0.92A 3oxvB-2q0lA:
undetectable		 3oxvB-2q0lA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_2
(HIV-1 PROTEASE)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 11 ALA A   5
VAL A  84
ILE A 108
GLY A   8
ILE A  93
 None
None
None
FAD  A 400 (-3.2A)
None
 0.82A 3oxvD-2q0lA:
undetectable		 3oxvD-2q0lA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_2
(HIV-1 PROTEASE)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 10 ALA A   5
VAL A  84
ILE A 108
GLY A   8
ILE A  93
 None
None
None
FAD  A 400 (-3.2A)
None
 0.84A 3oxwB-2q0lA:
undetectable		 3oxwB-2q0lA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_A_DR7A100_1
(HIV-1 PROTEASE)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 12 ALA A   5
VAL A  84
ILE A 108
GLY A   8
ILE A  93
 None
None
None
FAD  A 400 (-3.2A)
None
 0.80A 3oxxA-2q0lA:
undetectable		 3oxxA-2q0lA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_3
(PROTEASE)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 12 ALA A   5
VAL A  84
ILE A 108
GLY A   8
ILE A  93
 None
None
None
FAD  A 400 (-3.2A)
None
 0.81A 3pwrB-2q0lA:
undetectable		 3pwrB-2q0lA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_2
(PROTEASE)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 12 ALA A   5
VAL A  84
ILE A 108
GLY A   8
ILE A  93
 None
None
None
FAD  A 400 (-3.2A)
None
 0.83A 3tkgD-2q0lA:
undetectable		 3tkgD-2q0lA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKW_B_017B401_2
(PROTEASE)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 12 ALA A   5
VAL A  84
ILE A 108
GLY A   8
ILE A  93
 None
None
None
FAD  A 400 (-3.2A)
None
 0.79A 3tkwB-2q0lA:
undetectable		 3tkwB-2q0lA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_3
(PROTEASE)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 12 ALA A   5
VAL A  84
ILE A 108
GLY A   8
ILE A  93
 None
None
None
FAD  A 400 (-3.2A)
None
 0.79A 3tl9B-2q0lA:
undetectable		 3tl9B-2q0lA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DCM_A_SAMA401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 11 GLY A 280
GLY A 111
ILE A 108
ASP A 281
PRO A  11
 FAD  A 400 (-3.3A)
FAD  A 400 (-3.3A)
None
FAD  A 400 (-2.7A)
FAD  A 400 (-3.4A)
 1.05A 4dcmA-2q0lA:
3.4		 4dcmA-2q0lA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQB_B_017B101_1
(ASPARTYL PROTEASE)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 12 ALA A   5
VAL A  84
ILE A 108
GLY A   8
ILE A  93
 None
None
None
FAD  A 400 (-3.2A)
None
 0.82A 4dqbA-2q0lA:
undetectable		 4dqbA-2q0lA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQF_B_017B101_1
(ASPARTYL PROTEASE)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 12 ALA A   5
VAL A  84
ILE A 108
GLY A   8
ILE A  93
 None
None
None
FAD  A 400 (-3.2A)
None
 0.91A 4dqfA-2q0lA:
undetectable		 4dqfA-2q0lA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_A_IMNA201_1
(TRANSTHYRETIN)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		3 / 3 LYS A 189
LEU A 185
ALA A 188
 None
 0.68A 4ikiA-2q0lA:
undetectable		 4ikiA-2q0lA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_1
(HIV-1 PROTEASE)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 12 ALA A   5
VAL A  84
ILE A 108
GLY A   8
ILE A  93
 None
None
None
FAD  A 400 (-3.2A)
None
 0.78A 4jecA-2q0lA:
undetectable		 4jecA-2q0lA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_2
(HIV-1 PROTEASE)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 12 ALA A   5
VAL A  84
ILE A 108
GLY A   8
ILE A  93
 None
None
None
FAD  A 400 (-3.2A)
None
 0.84A 4jecB-2q0lA:
undetectable		 4jecB-2q0lA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JXC_A_SAMA402_0
(FEFE-HYDROGENASE
MATURASE)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 12 CYH A 166
SER A 131
GLY A 129
ILE A 194
LEU A 162
 None
FAD  A 400 ( 4.0A)
None
None
None
 1.42A 4jxcA-2q0lA:
undetectable		 4jxcA-2q0lA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYK_B_IMNB300_1
(LACTOYLGLUTATHIONE
LYASE)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 12 ALA A 293
LEU A  30
PHE A  70
GLY A  58
MET A  62
 FAD  A 400 (-3.6A)
None
None
None
None
 1.29A 4kykA-2q0lA:
undetectable
4kykB-2q0lA:
undetectable		 4kykA-2q0lA:
21.86
4kykB-2q0lA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 11 ALA A  20
TYR A  19
PHE A  72
SER A  15
GLY A  17
 None
 1.19A 4mmaA-2q0lA:
undetectable		 4mmaA-2q0lA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 9 ALA A  20
TYR A  19
PHE A  72
SER A  15
GLY A  17
 None
 1.35A 4mmbA-2q0lA:
undetectable		 4mmbA-2q0lA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_B_017B101_1
(PROTEASE)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 11 ALA A   5
VAL A  84
ILE A 108
GLY A   8
ILE A  93
 None
None
None
FAD  A 400 (-3.2A)
None
 0.93A 4njtA-2q0lA:
undetectable		 4njtA-2q0lA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_D_017D101_1
(PROTEASE)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 11 ALA A   5
VAL A  84
ILE A 108
GLY A   8
ILE A  93
 None
None
None
FAD  A 400 (-3.2A)
None
 0.93A 4njtC-2q0lA:
undetectable		 4njtC-2q0lA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_2
(PROTEASE)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 12 ALA A   5
VAL A  84
ILE A 108
GLY A   8
ILE A  93
 None
None
None
FAD  A 400 (-3.2A)
None
 0.79A 4njvD-2q0lA:
undetectable		 4njvD-2q0lA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_2
(PROTEASE)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 11 ALA A   5
VAL A  84
ILE A 108
GLY A   8
ILE A  93
 None
None
None
FAD  A 400 (-3.2A)
None
 0.84A 4qgiB-2q0lA:
undetectable		 4qgiB-2q0lA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_B_478B101_1
(HIV-1 PROTEASE)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 11 ALA A   5
VAL A  84
ILE A 108
GLY A   8
ILE A  93
 None
None
None
FAD  A 400 (-3.2A)
None
 0.99A 4rvjA-2q0lA:
undetectable		 4rvjA-2q0lA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_D_478D101_1
(HIV-1 PROTEASE)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 11 ALA A   5
VAL A  84
ILE A 108
GLY A   8
ILE A  93
 None
None
None
FAD  A 400 (-3.2A)
None
 0.99A 4rvjC-2q0lA:
undetectable		 4rvjC-2q0lA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		4 / 7 VAL A  25
ILE A   6
ALA A 300
ILE A   7
 None
 0.80A 4uxqA-2q0lA:
undetectable		 4uxqA-2q0lA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_A_BEZA1001_0
(BENZOATE-COENZYME A
LIGASE)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		4 / 8 ALA A 279
GLY A 297
ALA A  16
GLY A  13
 None
 0.66A 4zjzA-2q0lA:
undetectable		 4zjzA-2q0lA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		4 / 6 LEU A  74
ALA A  20
SER A  15
VAL A 304
 None
 1.20A 5a6iA-2q0lA:
undetectable		 5a6iA-2q0lA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_1
(PROTEASE E35D-DRV)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 12 ALA A   5
VAL A  84
ILE A 108
GLY A   8
ILE A  93
 None
None
None
FAD  A 400 (-3.2A)
None
 0.80A 5kqyA-2q0lA:
undetectable		 5kqyA-2q0lA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3A_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 12 HIS A  76
PHE A  70
GLY A  10
GLY A  13
ALA A 109
 None
None
FAD  A 400 (-3.4A)
None
None
 1.15A 6b3aA-2q0lA:
undetectable		 6b3aA-2q0lA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3B_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 12 HIS A  76
PHE A  70
GLY A  10
GLY A  13
ALA A 109
 None
None
FAD  A 400 (-3.4A)
None
None
 1.08A 6b3bA-2q0lA:
2.2		 6b3bA-2q0lA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH3_A_017A101_1
(PROTEASE)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 12 ALA A   5
VAL A  84
ILE A 108
GLY A   8
ILE A  93
 None
None
None
FAD  A 400 (-3.2A)
None
 0.92A 6dh3B-2q0lA:
undetectable		 6dh3B-2q0lA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH6_A_017A104_0
(PROTEASE)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 12 ALA A   5
VAL A  84
ILE A 108
GLY A   8
ILE A  93
 None
None
None
FAD  A 400 (-3.2A)
None
 0.90A 6dh6A-2q0lA:
undetectable		 6dh6A-2q0lA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH6_A_017A104_1
(PROTEASE)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 12 ALA A   5
VAL A  84
ILE A 108
GLY A   8
ILE A  93
 None
None
None
FAD  A 400 (-3.2A)
None
 0.93A 6dh6B-2q0lA:
undetectable		 6dh6B-2q0lA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIF_B_TPVB201_1
(HIV-1 PROTEASE)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 12 ALA A   5
VAL A  84
ILE A 108
GLY A   8
ILE A  93
 None
None
None
FAD  A 400 (-3.2A)
None
 0.88A 6difB-2q0lA:
undetectable		 6difB-2q0lA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIL_B_TPVB201_1
(HIV-1 PROTEASE)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 12 ALA A   5
VAL A  84
ILE A 108
GLY A   8
ILE A  93
 None
None
None
FAD  A 400 (-3.2A)
None
 0.83A 6dilB-2q0lA:
undetectable		 6dilB-2q0lA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_0
(ADENOSYLHOMOCYSTEINA
SE)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 10 GLY A   8
GLY A  10
GLU A  32
THR A 110
ASN A 242
 FAD  A 400 (-3.2A)
FAD  A 400 (-3.4A)
FAD  A 400 (-2.8A)
FAD  A 400 (-4.2A)
None
 0.89A 6exiA-2q0lA:
2.6		 6exiA-2q0lA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_1
(ADENOSYLHOMOCYSTEINA
SE)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 10 GLY A   8
GLY A  10
GLU A  32
THR A 110
ASN A 242
 FAD  A 400 (-3.2A)
FAD  A 400 (-3.4A)
FAD  A 400 (-2.8A)
FAD  A 400 (-4.2A)
None
 0.91A 6exiB-2q0lA:
3.6		 6exiB-2q0lA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC503_0
(ADENOSYLHOMOCYSTEINA
SE)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 12 GLY A   8
GLY A  10
GLU A  32
THR A 110
ASN A 242
 FAD  A 400 (-3.2A)
FAD  A 400 (-3.4A)
FAD  A 400 (-2.8A)
FAD  A 400 (-4.2A)
None
 0.91A 6exiC-2q0lA:
3.9
6exiD-2q0lA:
3.8		 6exiC-2q0lA:
12.70
6exiD-2q0lA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND503_0
(ADENOSYLHOMOCYSTEINA
SE)		 2q0l THIOREDOXIN
REDUCTASE
(Helicobacter
pylori) 		5 / 12 GLY A   8
GLY A  10
GLU A  32
THR A 110
ASN A 242
 FAD  A 400 (-3.2A)
FAD  A 400 (-3.4A)
FAD  A 400 (-2.8A)
FAD  A 400 (-4.2A)
None
 0.90A 6exiC-2q0lA:
3.9
6exiD-2q0lA:
3.8		 6exiC-2q0lA:
12.70
6exiD-2q0lA:
12.70