SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2q0o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_2
(DIHYDROFOLATE
REDUCTASE)		 2q0o PROBABLE
TRANSCRIPTIONAL
ACTIVATOR PROTEIN
TRAR
PROBABLE
TRANSCRIPTIONAL
REPRESSOR TRAM
(Sinorhizobium
fredii) 		3 / 3 TRP C  44
ARG A 205
THR A 200
 None
 0.73A 1df7A-2q0oC:
undetectable		 1df7A-2q0oC:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_2
(ESTROGEN RECEPTOR)		 2q0o PROBABLE
TRANSCRIPTIONAL
ACTIVATOR PROTEIN
TRAR
PROBABLE
TRANSCRIPTIONAL
REPRESSOR TRAM
(Sinorhizobium
fredii) 		4 / 6 LEU A 161
ASP C  72
MET A 128
LEU A 154
 None
 1.10A 1errB-2q0oA:
undetectable		 1errB-2q0oA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3004_1
(SERUM ALBUMIN)		 2q0o PROBABLE
TRANSCRIPTIONAL
ACTIVATOR PROTEIN
TRAR
(Sinorhizobium
fredii) 		4 / 6 PHE A  30
LEU A  14
VAL A 157
MET A 156
 None
 0.84A 1hk1A-2q0oA:
undetectable		 1hk1A-2q0oA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3004_1
(SERUM ALBUMIN)		 2q0o PROBABLE
TRANSCRIPTIONAL
ACTIVATOR PROTEIN
TRAR
(Sinorhizobium
fredii) 		4 / 7 PHE A  30
LEU A  14
VAL A 157
MET A 156
 None
 0.86A 1hk2A-2q0oA:
undetectable		 1hk2A-2q0oA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3004_1
(SERUM ALBUMIN)		 2q0o PROBABLE
TRANSCRIPTIONAL
ACTIVATOR PROTEIN
TRAR
(Sinorhizobium
fredii) 		4 / 7 PHE A  30
LEU A  14
VAL A 157
MET A 156
 None
 0.84A 1hk3A-2q0oA:
undetectable		 1hk3A-2q0oA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2q0o PROBABLE
TRANSCRIPTIONAL
ACTIVATOR PROTEIN
TRAR
(Sinorhizobium
fredii) 		4 / 5 LEU A  75
ASP A  72
GLY A 115
ALA A  78
 None
LAE  A1001 (-3.0A)
None
None
 0.70A 2aohA-2q0oA:
undetectable		 2aohA-2q0oA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2q0o PROBABLE
TRANSCRIPTIONAL
ACTIVATOR PROTEIN
TRAR
(Sinorhizobium
fredii) 		4 / 5 LEU A  75
ASP A  72
GLY A 115
ALA A  78
 None
LAE  A1001 (-3.0A)
None
None
 0.66A 2aohB-2q0oA:
undetectable		 2aohB-2q0oA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_2
(ESTROGEN RECEPTOR)		 2q0o PROBABLE
TRANSCRIPTIONAL
ACTIVATOR PROTEIN
TRAR
PROBABLE
TRANSCRIPTIONAL
REPRESSOR TRAM
(Sinorhizobium
fredii) 		4 / 5 LEU A 161
ASP C  72
MET A 128
LEU A 154
 None
 1.10A 2jfaA-2q0oA:
undetectable		 2jfaA-2q0oA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KUH_A_HLTA150_1
(CALMODULIN)		 2q0o PROBABLE
TRANSCRIPTIONAL
ACTIVATOR PROTEIN
TRAR
(Sinorhizobium
fredii) 		4 / 6 LEU A 184
LEU A 235
MET A 181
GLU A 180
 None
 1.24A 2kuhA-2q0oA:
undetectable		 2kuhA-2q0oA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_2
(ESTROGEN RECEPTOR)		 2q0o PROBABLE
TRANSCRIPTIONAL
ACTIVATOR PROTEIN
TRAR
PROBABLE
TRANSCRIPTIONAL
REPRESSOR TRAM
(Sinorhizobium
fredii) 		4 / 5 LEU A 161
ASP C  72
MET A 128
LEU A 154
 None
 1.10A 2qxsA-2q0oA:
undetectable		 2qxsA-2q0oA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_2
(ESTROGEN RECEPTOR)		 2q0o PROBABLE
TRANSCRIPTIONAL
ACTIVATOR PROTEIN
TRAR
PROBABLE
TRANSCRIPTIONAL
REPRESSOR TRAM
(Sinorhizobium
fredii) 		4 / 5 LEU A 161
ASP C  72
MET A 128
LEU A 154
 None
 1.07A 2qxsB-2q0oA:
undetectable		 2qxsB-2q0oA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_B_FLPB701_1
(CYCLOOXYGENASE-2)		 2q0o PROBABLE
TRANSCRIPTIONAL
ACTIVATOR PROTEIN
TRAR
PROBABLE
TRANSCRIPTIONAL
REPRESSOR TRAM
(Sinorhizobium
fredii) 		5 / 11 LEU C  92
TYR C  20
LEU C  28
TRP A 186
ALA C  35
 None
 1.26A 3pghB-2q0oC:
undetectable		 3pghB-2q0oC:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_1
(GLYCINE
N-METHYLTRANSFERASE)		 2q0o PROBABLE
TRANSCRIPTIONAL
ACTIVATOR PROTEIN
TRAR
(Sinorhizobium
fredii) 		3 / 3 LEU A 154
HIS A 158
MET A 155
 None
 0.95A 3thrD-2q0oA:
undetectable		 3thrD-2q0oA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1004_1
(HEMOLYTIC LECTIN
CEL-III)		 2q0o PROBABLE
TRANSCRIPTIONAL
REPRESSOR TRAM
(Sinorhizobium
fredii) 		4 / 5 ASP C  90
GLU C  17
TYR C  20
GLU C  87
 None
 1.33A 3w9tA-2q0oC:
undetectable		 3w9tA-2q0oC:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1002_1
(HEMOLYTIC LECTIN
CEL-III)		 2q0o PROBABLE
TRANSCRIPTIONAL
REPRESSOR TRAM
(Sinorhizobium
fredii) 		4 / 5 ASP C  90
GLU C  17
TYR C  20
GLU C  87
 None
 1.32A 3w9tC-2q0oC:
undetectable		 3w9tC-2q0oC:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD512_1
(HEMOLYTIC LECTIN
CEL-III)		 2q0o PROBABLE
TRANSCRIPTIONAL
REPRESSOR TRAM
(Sinorhizobium
fredii) 		4 / 5 ASP C  90
GLU C  17
TYR C  20
GLU C  87
 None
 1.33A 3w9tD-2q0oC:
undetectable		 3w9tD-2q0oC:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG502_1
(HEMOLYTIC LECTIN
CEL-III)		 2q0o PROBABLE
TRANSCRIPTIONAL
REPRESSOR TRAM
(Sinorhizobium
fredii) 		4 / 5 ASP C  90
GLU C  17
TYR C  20
GLU C  87
 None
 1.33A 3w9tG-2q0oC:
undetectable		 3w9tG-2q0oC:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2q0o PROBABLE
TRANSCRIPTIONAL
ACTIVATOR PROTEIN
TRAR
PROBABLE
TRANSCRIPTIONAL
REPRESSOR TRAM
(Sinorhizobium
fredii;
Sinorhizobium
fredii) 		4 / 8 ILE A 202
GLY A 201
SER A 188
GLN C  85
 None
 0.85A 4acbB-2q0oA:
undetectable
4acbC-2q0oA:
undetectable		 4acbB-2q0oA:
19.06
4acbC-2q0oA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_E_EDTE301_0
(BETA-2-MICROGLOBULIN
TCRBETA CHAIN)		 2q0o PROBABLE
TRANSCRIPTIONAL
ACTIVATOR PROTEIN
TRAR
(Sinorhizobium
fredii) 		4 / 8 SER A 109
ARG A  38
PRO A 135
ILE A 112
 None
None
None
LAE  A1001 (-4.2A)
 0.93A 5jhdE-2q0oA:
undetectable
5jhdG-2q0oA:
undetectable		 5jhdE-2q0oA:
23.70
5jhdG-2q0oA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_0
(REGULATORY PROTEIN
TETR)		 2q0o PROBABLE
TRANSCRIPTIONAL
ACTIVATOR PROTEIN
TRAR
(Sinorhizobium
fredii) 		5 / 12 ALA A  40
LEU A 154
VAL A  74
ASP A  83
PHE A  85
 LAE  A1001 ( 3.9A)
None
LAE  A1001 ( 4.6A)
None
None
 1.42A 5vlmD-2q0oA:
undetectable		 5vlmD-2q0oA:
22.46