SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2q0q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J7K_A_ACTA701_0
(HOLLIDAY JUNCTION
DNA HELICASE RUVB)		 2q0q ARYL ESTERASE
(Mycolicibacteriu
m
smegmatis) 		4 / 4 GLY A  52
LEU A  53
GLY A   9
ARG A  56
 None
 1.44A 1j7kA-2q0qA:
undetectable		 1j7kA-2q0qA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2q0q ARYL ESTERASE
(Mycolicibacteriu
m
smegmatis) 		4 / 4 THR A 161
LEU A 164
VAL A 167
LEU A 171
 None
 0.97A 1mz9D-2q0qA:
undetectable		 1mz9D-2q0qA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_2
(PROTEASE)		 2q0q ARYL ESTERASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 ARG A  33
VAL A  19
THR A  25
 GOL  A1730 (-2.9A)
None
None
 0.84A 2nnkA-2q0qA:
undetectable		 2nnkA-2q0qA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_A_PNTA901_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 2q0q ARYL ESTERASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 THR A  35
GLY A 183
SER A 184
VAL A 185
ASN A 201
 None
 1.49A 3hiiA-2q0qA:
0.0		 3hiiA-2q0qA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_B_PNTB901_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 2q0q ARYL ESTERASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 THR A  35
GLY A 183
SER A 184
VAL A 185
ASN A 201
 None
 1.48A 3hiiB-2q0qA:
0.0		 3hiiB-2q0qA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_2
(HIV-1 PROTEASE)		 2q0q ARYL ESTERASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 ARG A  33
VAL A  19
THR A  25
 GOL  A1730 (-2.9A)
None
None
 0.79A 3k4vA-2q0qA:
undetectable		 3k4vA-2q0qA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_4
(HIV-1 PROTEASE)		 2q0q ARYL ESTERASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 ARG A  33
VAL A  19
THR A  25
 GOL  A1730 (-2.9A)
None
None
 0.76A 3k4vD-2q0qA:
undetectable		 3k4vD-2q0qA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_2
(PROTEASE)		 2q0q ARYL ESTERASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 ARG A  33
VAL A  19
THR A  25
 GOL  A1730 (-2.9A)
None
None
 0.72A 3ndtA-2q0qA:
undetectable		 3ndtA-2q0qA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_3
(PROTEASE)		 2q0q ARYL ESTERASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 ARG A  33
VAL A  19
THR A  25
 GOL  A1730 (-2.9A)
None
None
 0.77A 3nduD-2q0qA:
undetectable		 3nduD-2q0qA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_2
(PROTEASE)		 2q0q ARYL ESTERASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 ARG A  33
VAL A  19
THR A  25
 GOL  A1730 (-2.9A)
None
None
 0.82A 3tl9A-2q0qA:
undetectable		 3tl9A-2q0qA:
18.72