SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2q0t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)		 2q0t PUTATIVE
GAMMA-CARBOXYMUCONOL
ACTONE DECARBOXYLASE
SUBUNIT
(Paraburkholderia
xenovorans) 		4 / 5 THR A 234
ASP A  68
HIS A  82
HIS A 237
 None
 0.91A 1ei6A-2q0tA:
undetectable		 1ei6A-2q0tA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		 2q0t PUTATIVE
GAMMA-CARBOXYMUCONOL
ACTONE DECARBOXYLASE
SUBUNIT
(Paraburkholderia
xenovorans) 		4 / 8 THR A 234
ASP A  68
HIS A  82
HIS A 237
 None
 0.92A 1ei6C-2q0tA:
undetectable		 1ei6C-2q0tA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1435_1
(CHITINASE)		 2q0t PUTATIVE
GAMMA-CARBOXYMUCONOL
ACTONE DECARBOXYLASE
SUBUNIT
(Paraburkholderia
xenovorans) 		3 / 3 TRP A 178
GLU A 189
TYR A 217
 None
 0.99A 2a3aA-2q0tA:
undetectable		 2a3aA-2q0tA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2q0t PUTATIVE
GAMMA-CARBOXYMUCONOL
ACTONE DECARBOXYLASE
SUBUNIT
(Paraburkholderia
xenovorans) 		4 / 6 ILE A  63
ILE A 236
TYR A  42
LEU A  55
 None
 0.92A 3adsA-2q0tA:
undetectable		 3adsA-2q0tA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_C_T44C128_1
(5-HYDROXYISOURATE
HYDROLASE)		 2q0t PUTATIVE
GAMMA-CARBOXYMUCONOL
ACTONE DECARBOXYLASE
SUBUNIT
(Paraburkholderia
xenovorans) 		4 / 6 LEU A 162
PRO A 164
PRO A 132
LEU A 134
 None
 1.11A 3q1eA-2q0tA:
undetectable
3q1eC-2q0tA:
undetectable		 3q1eA-2q0tA:
18.97
3q1eC-2q0tA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB204_1
(CALMODULIN)		 2q0t PUTATIVE
GAMMA-CARBOXYMUCONOL
ACTONE DECARBOXYLASE
SUBUNIT
(Paraburkholderia
xenovorans) 		4 / 8 LEU A 241
GLY A 238
GLU A 240
ALA A 199
 None
 0.85A 4rjdA-2q0tA:
undetectable
4rjdB-2q0tA:
undetectable		 4rjdA-2q0tA:
10.27
4rjdB-2q0tA:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2q0t PUTATIVE
GAMMA-CARBOXYMUCONOL
ACTONE DECARBOXYLASE
SUBUNIT
(Paraburkholderia
xenovorans) 		4 / 7 ILE A  83
PHE A 190
ILE A  63
PHE A 195
 None
 0.84A 5hieC-2q0tA:
undetectable		 5hieC-2q0tA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_G_6ELG501_0
(PROTEIN CEREBLON)		 2q0t PUTATIVE
GAMMA-CARBOXYMUCONOL
ACTONE DECARBOXYLASE
SUBUNIT
(Paraburkholderia
xenovorans) 		4 / 8 HIS A  21
PHE A  89
HIS A 237
THR A 234
 None
 1.46A 5yj1G-2q0tA:
undetectable
5yj1Y-2q0tA:
undetectable		 5yj1G-2q0tA:
14.94
5yj1Y-2q0tA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2q0t PUTATIVE
GAMMA-CARBOXYMUCONOL
ACTONE DECARBOXYLASE
SUBUNIT
(Paraburkholderia
xenovorans) 		3 / 3 ARG A 137
LEU A 141
PHE A 145
 None
 0.57A 6nknP-2q0tA:
undetectable		 6nknP-2q0tA:
22.68