SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2q12'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		 2q12 DCC-INTERACTING
PROTEIN 13 ALPHA
(Homo
sapiens) 		4 / 8 GLU A  95
ASN A 217
LEU A 222
LEU A 226
 None
 0.87A 1hwiB-2q12A:
undetectable		 1hwiB-2q12A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		 2q12 DCC-INTERACTING
PROTEIN 13 ALPHA
(Homo
sapiens) 		4 / 8 GLU A  95
ASN A 217
LEU A 222
LEU A 226
 None
 0.92A 1hwiD-2q12A:
undetectable		 1hwiD-2q12A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		 2q12 DCC-INTERACTING
PROTEIN 13 ALPHA
(Homo
sapiens) 		4 / 8 GLU A  95
ASN A 217
LEU A 222
LEU A 226
 None
 0.91A 1hwiC-2q12A:
undetectable		 1hwiC-2q12A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLO_A_TESA1920_1
(ANDROGEN RECEPTOR)		 2q12 DCC-INTERACTING
PROTEIN 13 ALPHA
(Homo
sapiens) 		5 / 12 GLN A 234
VAL A 236
ARG A 238
THR A  85
PHE A 225
 None
 1.46A 2yloA-2q12A:
undetectable		 2yloA-2q12A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2q12 DCC-INTERACTING
PROTEIN 13 ALPHA
(Homo
sapiens) 		4 / 6 ASP A 141
HIS A 140
ARG A 171
ILE A 144
 None
 1.16A 5a06A-2q12A:
undetectable		 5a06A-2q12A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2q12 DCC-INTERACTING
PROTEIN 13 ALPHA
(Homo
sapiens) 		4 / 5 ASP A 141
HIS A 140
ARG A 171
ILE A 144
 None
 1.13A 5a06B-2q12A:
undetectable		 5a06B-2q12A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1344_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2q12 DCC-INTERACTING
PROTEIN 13 ALPHA
(Homo
sapiens) 		4 / 5 ASP A 141
HIS A 140
ARG A 171
ILE A 144
 None
 1.13A 5a06D-2q12A:
undetectable		 5a06D-2q12A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1344_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2q12 DCC-INTERACTING
PROTEIN 13 ALPHA
(Homo
sapiens) 		4 / 5 ASP A 141
HIS A 140
ARG A 171
ILE A 144
 None
 1.13A 5a06F-2q12A:
undetectable		 5a06F-2q12A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2q12 DCC-INTERACTING
PROTEIN 13 ALPHA
(Homo
sapiens) 		4 / 9 TYR A 190
LYS A 193
ILE A 194
LEU A 201
 None
 0.44A 5vkqB-2q12A:
2.4
5vkqC-2q12A:
2.4		 5vkqB-2q12A:
9.54
5vkqC-2q12A:
9.54