SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2q14'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC8_0
(GRAMICIDIN A)		 2q14 PHOSPHOHYDROLASE
(Bacteroides
thetaiotaomicron) 		3 / 4 VAL A 294
TRP A 289
TRP A 295
 None
 1.43A 1gmkC-2q14A:
undetectable
1gmkD-2q14A:
undetectable		 1gmkC-2q14A:
2.98
1gmkD-2q14A:
2.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_4
(HIV-1 PROTEASE)		 2q14 PHOSPHOHYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 4 GLY A  42
ASP A 285
GLY A 100
THR A 109
 None
 1.09A 1hxbB-2q14A:
undetectable		 1hxbB-2q14A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_1
(MODIFICATION
METHYLASE RSRI)		 2q14 PHOSPHOHYDROLASE
(Bacteroides
thetaiotaomicron) 		3 / 3 ASP A 165
HIS A  95
ASP A 160
 None
 0.90A 1nw5A-2q14A:
undetectable		 1nw5A-2q14A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OAF_A_ASCA1253_0
(ASCORBATE PEROXIDASE)		 2q14 PHOSPHOHYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 6 CYH A 276
PRO A 274
LEU A 277
ARG A 126
 None
 1.30A 1oafA-2q14A:
0.0		 1oafA-2q14A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_0
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 2q14 PHOSPHOHYDROLASE
(Bacteroides
thetaiotaomicron) 		5 / 12 LEU A 151
ALA A  87
ILE A 139
ILE A  70
PHE A 150
 None
 1.06A 2ejtA-2q14A:
undetectable		 2ejtA-2q14A:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_2
(ESTROGEN RECEPTOR)		 2q14 PHOSPHOHYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 5 LEU A  35
ASP A 285
LEU A 123
HIS A 116
 None
 1.28A 2jfaA-2q14A:
undetectable		 2jfaA-2q14A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_2
(ESTROGEN RECEPTOR)		 2q14 PHOSPHOHYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 4 LEU A  35
THR A  36
ILE A  26
HIS A  29
 None
 1.36A 2jfaB-2q14A:
undetectable		 2jfaB-2q14A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_NIMA300_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 2q14 PHOSPHOHYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 5 LEU A 151
ALA A  69
ILE A  70
LYS A 148
 None
 1.16A 2othA-2q14A:
undetectable		 2othA-2q14A:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_A_CLUA808_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 2q14 PHOSPHOHYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 7 ALA A  51
TYR A  48
MET A 217
HIS A  53
 None
 1.36A 2pncA-2q14A:
undetectable		 2pncA-2q14A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_B_CLUB809_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 2q14 PHOSPHOHYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 6 ALA A  51
TYR A  48
MET A 217
HIS A  53
 None
 1.43A 2pncB-2q14A:
undetectable		 2pncB-2q14A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_A_SHHA301_1
(HISTONE DEACETYLASE
7A)		 2q14 PHOSPHOHYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 5 HIS A  99
HIS A 116
ASP A  96
ASP A 162
 None
 1.09A 3c0zA-2q14A:
undetectable		 3c0zA-2q14A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_C_SHHC301_1
(HISTONE DEACETYLASE
7A)		 2q14 PHOSPHOHYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 6 HIS A  99
HIS A 116
ASP A  96
ASP A 162
 None
 1.10A 3c0zC-2q14A:
undetectable		 3c0zC-2q14A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 2q14 PHOSPHOHYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 8 ASP A 162
SER A 156
ASP A 367
TYR A 222
 None
None
None
EDO  A 502 ( 4.3A)
 1.00A 3havA-2q14A:
undetectable		 3havA-2q14A:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3008_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2q14 PHOSPHOHYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 7 HIS A  58
GLN A  40
VAL A  41
ALA A  51
 None
EDO  A 502 (-4.1A)
EDO  A 502 (-4.8A)
None
 1.05A 3kp6B-2q14A:
undetectable		 3kp6B-2q14A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_A_AC2A301_1
(DEOXYCYTIDINE KINASE)		 2q14 PHOSPHOHYDROLASE
(Bacteroides
thetaiotaomicron) 		5 / 9 ILE A  80
GLN A 153
ASP A 195
PHE A 150
LEU A  73
 None
 1.13A 3mjrA-2q14A:
undetectable		 3mjrA-2q14A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU5_B_478B401_2
(PROTEASE)		 2q14 PHOSPHOHYDROLASE
(Bacteroides
thetaiotaomicron) 		5 / 12 GLY A  61
ALA A  62
ASP A 162
VAL A 155
ILE A  92
 None
 1.07A 3nu5B-2q14A:
undetectable		 3nu5B-2q14A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_A_ADNA506_2
(ADENOSYLHOMOCYSTEINA
SE)		 2q14 PHOSPHOHYDROLASE
(Bacteroides
thetaiotaomicron) 		3 / 3 GLN A  40
THR A  54
LEU A  93
 EDO  A 502 (-4.1A)
None
None
 0.67A 3ondA-2q14A:
undetectable		 3ondA-2q14A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_B_ADNB507_2
(ADENOSYLHOMOCYSTEINA
SE)		 2q14 PHOSPHOHYDROLASE
(Bacteroides
thetaiotaomicron) 		3 / 3 GLN A  40
THR A  54
LEU A  93
 EDO  A 502 (-4.1A)
None
None
 0.66A 3ondB-2q14A:
undetectable		 3ondB-2q14A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HAJ_A_DXCA75_0
(PPCA)		 2q14 PHOSPHOHYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 7 ILE A 288
LEU A 106
PHE A 280
GLY A  98
 None
 1.01A 4hajA-2q14A:
undetectable		 4hajA-2q14A:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O4D_A_ACTA406_0
(INOSITOL
HEXAKISPHOSPHATE
KINASE)		 2q14 PHOSPHOHYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 7 ARG A  55
PHE A 102
SER A 103
HIS A 104
 None
 1.46A 4o4dA-2q14A:
undetectable		 4o4dA-2q14A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2q14 PHOSPHOHYDROLASE
(Bacteroides
thetaiotaomicron) 		5 / 12 VAL A 302
LEU A 257
LEU A 251
LEU A 238
ALA A 245
 None
 1.26A 4x1kA-2q14A:
undetectable
4x1kB-2q14A:
undetectable		 4x1kA-2q14A:
21.53
4x1kB-2q14A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF8_B_LBHB2004_1
(HDAC6 PROTEIN)		 2q14 PHOSPHOHYDROLASE
(Bacteroides
thetaiotaomicron) 		5 / 12 HIS A  99
HIS A 116
ASP A  96
ASP A 162
TYR A 166
 None
None
None
None
EDO  A 502 ( 3.6A)
 1.48A 5ef8B-2q14A:
undetectable		 5ef8B-2q14A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JM4_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 2q14 PHOSPHOHYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 5 PHE A 210
ILE A 186
GLN A 158
ARG A 163
 None
 1.11A 5jm4A-2q14A:
undetectable		 5jm4A-2q14A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JM4_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 2q14 PHOSPHOHYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 4 PHE A 210
ILE A 186
GLN A 158
ARG A 163
 None
 1.09A 5jm4B-2q14A:
0.3		 5jm4B-2q14A:
21.07