SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2q17'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB6_0
(GRAMICIDIN A)		 2q17 FORMYLGLYCINE
GENERATING ENZYME
(Streptomyces
coelicolor) 		3 / 3 TRP A 123
ALA A  85
VAL A 144
 None
 0.84A 1bdwA-2q17A:
undetectable
1bdwB-2q17A:
undetectable		 1bdwA-2q17A:
5.11
1bdwB-2q17A:
5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA732_1
(ALPHA AMYLASE)		 2q17 FORMYLGLYCINE
GENERATING ENZYME
(Streptomyces
coelicolor) 		5 / 9 GLY A 295
GLU A 235
GLY A 298
GLY A 268
GLY A 231
 None
 0.95A 1mxdA-2q17A:
undetectable		 1mxdA-2q17A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA732_1
(ALPHA AMYLASE)		 2q17 FORMYLGLYCINE
GENERATING ENZYME
(Streptomyces
coelicolor) 		5 / 9 GLY A 295
PRO A 140
GLY A 298
GLY A 268
GLY A 231
 None
 1.14A 1mxdA-2q17A:
undetectable		 1mxdA-2q17A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA442_1
(ALPHA AMYLASE)		 2q17 FORMYLGLYCINE
GENERATING ENZYME
(Streptomyces
coelicolor) 		5 / 11 GLY A 295
GLU A 235
GLY A 298
GLY A 268
GLY A 231
 None
 0.94A 1mxgA-2q17A:
undetectable		 1mxgA-2q17A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OM5_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2q17 FORMYLGLYCINE
GENERATING ENZYME
(Streptomyces
coelicolor) 		4 / 8 TRP A 234
TRP A 166
TRP A 236
GLU A 235
 None
 1.31A 1om5A-2q17A:
undetectable
1om5B-2q17A:
undetectable		 1om5A-2q17A:
19.45
1om5B-2q17A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_B_ADNB2002_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 2q17 FORMYLGLYCINE
GENERATING ENZYME
(Streptomyces
coelicolor) 		4 / 6 ARG A  28
GLU A  64
ASN A 222
ALA A 169
 None
 1.38A 2ejfB-2q17A:
undetectable		 2ejfB-2q17A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_A_ADNA1501_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 2q17 FORMYLGLYCINE
GENERATING ENZYME
(Streptomyces
coelicolor) 		4 / 7 ARG A  28
GLU A  64
ASN A 222
ALA A 169
 None
 1.31A 2ejgA-2q17A:
undetectable		 2ejgA-2q17A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G6H_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2q17 FORMYLGLYCINE
GENERATING ENZYME
(Streptomyces
coelicolor) 		4 / 8 TRP A 234
TRP A 166
TRP A 236
GLU A 235
 None
 1.32A 2g6hA-2q17A:
undetectable
2g6hB-2q17A:
undetectable		 2g6hA-2q17A:
19.50
2g6hB-2q17A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_2
(PROTEASE RETROPEPSIN)		 2q17 FORMYLGLYCINE
GENERATING ENZYME
(Streptomyces
coelicolor) 		3 / 3 ARG A 124
THR A  79
VAL A  76
 None
 0.82A 2q64A-2q17A:
undetectable		 2q64A-2q17A:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 2q17 FORMYLGLYCINE
GENERATING ENZYME
(Streptomyces
coelicolor) 		3 / 3 ARG A 124
THR A  79
VAL A  76
 None
 0.82A 2qakA-2q17A:
undetectable		 2qakA-2q17A:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B3P_B_H4BB760_1
(NITRIC-OXIDE
SYNTHASE)		 2q17 FORMYLGLYCINE
GENERATING ENZYME
(Streptomyces
coelicolor) 		4 / 8 TRP A 166
TRP A 236
GLU A 235
TRP A 234
 None
 1.37A 3b3pA-2q17A:
undetectable
3b3pB-2q17A:
undetectable		 3b3pA-2q17A:
19.63
3b3pB-2q17A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_D_H4BD3902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2q17 FORMYLGLYCINE
GENERATING ENZYME
(Streptomyces
coelicolor) 		4 / 8 TRP A 166
TRP A 236
GLU A 235
TRP A 234
 None
 1.25A 3e7gC-2q17A:
undetectable
3e7gD-2q17A:
undetectable		 3e7gC-2q17A:
21.57
3e7gD-2q17A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB8_0
(GRAMICIDIN D)		 2q17 FORMYLGLYCINE
GENERATING ENZYME
(Streptomyces
coelicolor) 		3 / 3 VAL A  76
VAL A  82
TRP A 123
 None
 0.91A 3l8lA-2q17A:
undetectable
3l8lB-2q17A:
undetectable		 3l8lA-2q17A:
5.11
3l8lB-2q17A:
5.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG306_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2q17 FORMYLGLYCINE
GENERATING ENZYME
(Streptomyces
coelicolor) 		3 / 3 ARG A 171
ARG A 266
ASP A  38
 None
 0.70A 3wipG-2q17A:
undetectable
3wipH-2q17A:
undetectable		 3wipG-2q17A:
19.32
3wipH-2q17A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_D_ACTD504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2q17 FORMYLGLYCINE
GENERATING ENZYME
(Streptomyces
coelicolor) 		3 / 3 GLY A 295
SER A 294
TRP A 115
 None
 0.91A 4e7cD-2q17A:
undetectable		 4e7cD-2q17A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 2q17 FORMYLGLYCINE
GENERATING ENZYME
(Streptomyces
coelicolor) 		4 / 8 HIS A 255
ASP A 239
ALA A 164
SER A 238
 None
 0.90A 4k0bB-2q17A:
undetectable		 4k0bB-2q17A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 2q17 FORMYLGLYCINE
GENERATING ENZYME
(Streptomyces
coelicolor) 		4 / 8 HIS A 255
ASP A 239
ALA A 164
SER A 238
 None
 0.89A 4l7iB-2q17A:
undetectable		 4l7iB-2q17A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCH_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2q17 FORMYLGLYCINE
GENERATING ENZYME
(Streptomyces
coelicolor) 		4 / 8 TRP A 166
TRP A 236
GLU A 235
TRP A 234
 None
 1.31A 4uchA-2q17A:
undetectable
4uchB-2q17A:
undetectable		 4uchA-2q17A:
20.89
4uchB-2q17A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3W_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2q17 FORMYLGLYCINE
GENERATING ENZYME
(Streptomyces
coelicolor) 		4 / 7 TRP A 166
TRP A 236
GLU A 235
TRP A 234
 None
 1.28A 4v3wA-2q17A:
undetectable
4v3wB-2q17A:
undetectable		 4v3wA-2q17A:
19.63
4v3wB-2q17A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WAN_C_ACTC303_0
(BRANCHPOINT-BRIDGING
PROTEIN)		 2q17 FORMYLGLYCINE
GENERATING ENZYME
(Streptomyces
coelicolor) 		3 / 3 ASP A 239
ARG A 159
PRO A 161
 None
 1.00A 4wanC-2q17A:
undetectable		 4wanC-2q17A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)		 2q17 FORMYLGLYCINE
GENERATING ENZYME
(Streptomyces
coelicolor) 		4 / 8 ARG A 285
ASP A  47
VAL A 282
ASP A  38
 None
 1.12A 4xqgA-2q17A:
undetectable		 4xqgA-2q17A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 2q17 FORMYLGLYCINE
GENERATING ENZYME
(Streptomyces
coelicolor) 		4 / 8 ARG A 285
ASP A  47
VAL A 282
ASP A  38
 None
 1.11A 4xqgB-2q17A:
undetectable		 4xqgB-2q17A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_B_ACTB1321_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT)		 2q17 FORMYLGLYCINE
GENERATING ENZYME
(Streptomyces
coelicolor) 		3 / 3 THR A  83
ASP A  84
ALA A  85
 None
 0.07A 5g5gB-2q17A:
undetectable		 5g5gB-2q17A:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVA_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2q17 FORMYLGLYCINE
GENERATING ENZYME
(Streptomyces
coelicolor) 		4 / 7 TRP A 234
TRP A 166
TRP A 236
GLU A 235
 None
 1.25A 5vvaA-2q17A:
undetectable
5vvaB-2q17A:
undetectable		 5vvaA-2q17A:
23.70
5vvaB-2q17A:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVD_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2q17 FORMYLGLYCINE
GENERATING ENZYME
(Streptomyces
coelicolor) 		4 / 7 TRP A 166
TRP A 236
GLU A 235
TRP A 234
 None
 1.26A 5vvdA-2q17A:
undetectable
5vvdB-2q17A:
undetectable		 5vvdA-2q17A:
22.86
5vvdB-2q17A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 2q17 FORMYLGLYCINE
GENERATING ENZYME
(Streptomyces
coelicolor) 		5 / 12 ALA A 262
GLY A 260
THR A 259
PRO A 257
LEU A 265
 None
 1.11A 5ybbA-2q17A:
undetectable		 5ybbA-2q17A:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_B_H4BB503_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2q17 FORMYLGLYCINE
GENERATING ENZYME
(Streptomyces
coelicolor) 		4 / 7 TRP A 166
TRP A 236
GLU A 235
TRP A 234
 None
 1.27A 6av6A-2q17A:
undetectable
6av6B-2q17A:
undetectable		 6av6A-2q17A:
11.56
6av6B-2q17A:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIE_B_H4BB502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2q17 FORMYLGLYCINE
GENERATING ENZYME
(Streptomyces
coelicolor) 		4 / 7 TRP A 166
TRP A 236
GLU A 235
TRP A 234
 None
 1.22A 6cieA-2q17A:
undetectable
6cieB-2q17A:
undetectable		 6cieA-2q17A:
11.56
6cieB-2q17A:
11.56