SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2q1t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA309_1
(BETA-LACTAMASE)		 2q1t PUTATIVE NUCLEOTIDE
SUGAR EPIMERASE/
DEHYDRATASE
(Bordetella
bronchiseptica) 		4 / 5 ILE A 241
ARG A 312
GLU A 148
GLU A 309
 None
 1.42A 3ny4A-2q1tA:
undetectable		 3ny4A-2q1tA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 2q1t PUTATIVE NUCLEOTIDE
SUGAR EPIMERASE/
DEHYDRATASE
(Bordetella
bronchiseptica) 		5 / 12 GLY A 195
GLU A 196
GLY A  25
ALA A 247
ASN A  53
 None
 1.06A 3qowA-2q1tA:
5.3		 3qowA-2q1tA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_1
(SCRFP-TAG,GP41)		 2q1t PUTATIVE NUCLEOTIDE
SUGAR EPIMERASE/
DEHYDRATASE
(Bordetella
bronchiseptica) 		5 / 12 GLY A 249
LEU A  32
LEU A  33
GLU A  34
LEU A  35
 None
 0.95A 5nwwA-2q1tA:
undetectable		 5nwwA-2q1tA:
6.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA602_0
(THIOCYANATE
DEHYDROGENASE)		 2q1t PUTATIVE NUCLEOTIDE
SUGAR EPIMERASE/
DEHYDRATASE
(Bordetella
bronchiseptica) 		3 / 3 LYS A 118
HIS A 119
HIS A 179
 None
 1.24A 5oexA-2q1tA:
undetectable		 5oexA-2q1tA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB602_0
(THIOCYANATE
DEHYDROGENASE)		 2q1t PUTATIVE NUCLEOTIDE
SUGAR EPIMERASE/
DEHYDRATASE
(Bordetella
bronchiseptica) 		3 / 3 LYS A 118
HIS A 119
HIS A 179
 None
 1.22A 5oexB-2q1tA:
undetectable		 5oexB-2q1tA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC603_0
(THIOCYANATE
DEHYDROGENASE)		 2q1t PUTATIVE NUCLEOTIDE
SUGAR EPIMERASE/
DEHYDRATASE
(Bordetella
bronchiseptica) 		3 / 3 LYS A 118
HIS A 119
HIS A 179
 None
 1.24A 5oexC-2q1tA:
undetectable		 5oexC-2q1tA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD603_0
(THIOCYANATE
DEHYDROGENASE)		 2q1t PUTATIVE NUCLEOTIDE
SUGAR EPIMERASE/
DEHYDRATASE
(Bordetella
bronchiseptica) 		3 / 3 LYS A 118
HIS A 119
HIS A 179
 None
 1.24A 5oexD-2q1tA:
undetectable		 5oexD-2q1tA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 2q1t PUTATIVE NUCLEOTIDE
SUGAR EPIMERASE/
DEHYDRATASE
(Bordetella
bronchiseptica) 		4 / 7 GLU A  64
PHE A  62
ALA A  49
GLY A 201
 None
None
NAD  A 358 (-3.1A)
None
 1.07A 5uxdA-2q1tA:
undetectable		 5uxdA-2q1tA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_1
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 2q1t PUTATIVE NUCLEOTIDE
SUGAR EPIMERASE/
DEHYDRATASE
(Bordetella
bronchiseptica) 		3 / 3 THR A  68
GLU A 104
HIS A 103
 NAD  A 358 ( 4.7A)
None
None
 0.89A 5xioA-2q1tA:
undetectable		 5xioA-2q1tA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 2q1t PUTATIVE NUCLEOTIDE
SUGAR EPIMERASE/
DEHYDRATASE
(Bordetella
bronchiseptica) 		3 / 3 THR A  68
GLU A 104
HIS A 103
 NAD  A 358 ( 4.7A)
None
None
 0.90A 5xiqB-2q1tA:
undetectable		 5xiqB-2q1tA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 2q1t PUTATIVE NUCLEOTIDE
SUGAR EPIMERASE/
DEHYDRATASE
(Bordetella
bronchiseptica) 		3 / 3 THR A  68
GLU A 104
HIS A 103
 NAD  A 358 ( 4.7A)
None
None
 0.86A 5xiqD-2q1tA:
undetectable		 5xiqD-2q1tA:
23.58