SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2q1z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_B_TESB904_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 2q1z ANTI-SIGMA FACTOR
CHRR,
TRANSCRIPTIONAL
ACTIVATOR CHRR
(Rhodobacter
sphaeroides) 		4 / 7 VAL B 114
ILE B 132
HIS B 143
GLU B 147
 None
None
ZN  B 197 (-4.1A)
ZN  B 197 (-2.2A)
 1.06A 1j96B-2q1zB:
undetectable		 1j96B-2q1zB:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2q1z ANTI-SIGMA FACTOR
CHRR,
TRANSCRIPTIONAL
ACTIVATOR CHRR
(Rhodobacter
sphaeroides) 		5 / 12 LEU B 102
LEU B 129
ALA B 127
LEU B  34
ILE B 168
 None
 1.01A 2h42C-2q1zB:
undetectable		 2h42C-2q1zB:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		 2q1z ANTI-SIGMA FACTOR
CHRR,
TRANSCRIPTIONAL
ACTIVATOR CHRR
(Rhodobacter
sphaeroides) 		3 / 3 GLU B 169
HIS B 141
GLU B 147
 None
ZN  B 197 (-3.5A)
ZN  B 197 (-2.2A)
 0.82A 2x45B-2q1zB:
undetectable		 2x45B-2q1zB:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		 2q1z ANTI-SIGMA FACTOR
CHRR,
TRANSCRIPTIONAL
ACTIVATOR CHRR
(Rhodobacter
sphaeroides) 		3 / 3 GLU B 169
HIS B 141
GLU B 147
 None
ZN  B 197 (-3.5A)
ZN  B 197 (-2.2A)
 0.81A 2x45C-2q1zB:
undetectable		 2x45C-2q1zB:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBP_A_SAMA300_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2q1z ANTI-SIGMA FACTOR
CHRR,
TRANSCRIPTIONAL
ACTIVATOR CHRR
(Rhodobacter
sphaeroides) 		5 / 12 PHE B 163
LEU B  34
GLY B 166
GLY B 164
LEU B 150
 None
 1.07A 2zbpA-2q1zB:
undetectable		 2zbpA-2q1zB:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA602_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 2q1z ANTI-SIGMA FACTOR
CHRR,
TRANSCRIPTIONAL
ACTIVATOR CHRR
(Rhodobacter
sphaeroides) 		4 / 7 SER B  21
ALA B 192
ALA B 127
ALA B 125
 None
 0.71A 3a2qA-2q1zB:
undetectable		 3a2qA-2q1zB:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_1
(FIV PROTEASE)		 2q1z ANTI-SIGMA FACTOR
CHRR,
TRANSCRIPTIONAL
ACTIVATOR CHRR
(Rhodobacter
sphaeroides) 		5 / 10 ALA B 192
GLY B 145
SER B   8
VAL B   7
LEU B 148
 None
 1.01A 3ogpA-2q1zB:
undetectable		 3ogpA-2q1zB:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTV_A_ADNA403_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2q1z ANTI-SIGMA FACTOR
CHRR,
TRANSCRIPTIONAL
ACTIVATOR CHRR
(Rhodobacter
sphaeroides) 		5 / 12 HIS B 177
PRO B 179
PHE B 163
ASP B 167
ILE B 170
 ZN  B 197 (-3.5A)
None
None
None
None
 1.45A 4ktvA-2q1zB:
undetectable
4ktvB-2q1zB:
undetectable		 4ktvA-2q1zB:
20.93
4ktvB-2q1zB:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_A_ACTA401_0
(UNCHARACTERIZED
PROTEIN)		 2q1z ANTI-SIGMA FACTOR
CHRR,
TRANSCRIPTIONAL
ACTIVATOR CHRR
(Rhodobacter
sphaeroides) 		5 / 9 GLY B 123
SER B  21
TYR B  97
GLY B 122
THR B 121
 None
 1.48A 4lb0A-2q1zB:
undetectable		 4lb0A-2q1zB:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2q1z ANTI-SIGMA FACTOR
CHRR,
TRANSCRIPTIONAL
ACTIVATOR CHRR
(Rhodobacter
sphaeroides) 		4 / 8 LEU B 129
THR B 121
LEU B  26
LEU B 190
 None
 0.72A 4z90F-2q1zB:
undetectable
4z90G-2q1zB:
undetectable
4z90H-2q1zB:
undetectable
4z90I-2q1zB:
undetectable
4z90J-2q1zB:
undetectable		 4z90F-2q1zB:
21.63
4z90G-2q1zB:
21.63
4z90H-2q1zB:
21.63
4z90I-2q1zB:
21.63
4z90J-2q1zB:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_A_NMYA303_0
(AAC(3)-IIIB PROTEIN)		 2q1z ANTI-SIGMA FACTOR
CHRR,
TRANSCRIPTIONAL
ACTIVATOR CHRR
(Rhodobacter
sphaeroides) 		5 / 10 ASP B 194
THR B 193
THR B 121
GLY B 122
GLU B 124
 None
 1.47A 6mb9A-2q1zB:
undetectable		 6mb9A-2q1zB:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_B_NMYB302_0
(AAC(3)-IIIB PROTEIN)		 2q1z ANTI-SIGMA FACTOR
CHRR,
TRANSCRIPTIONAL
ACTIVATOR CHRR
(Rhodobacter
sphaeroides) 		5 / 10 ASP B 194
THR B 193
THR B 121
GLY B 122
GLU B 124
 None
 1.49A 6mb9B-2q1zB:
undetectable		 6mb9B-2q1zB:
23.96