SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2q22'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Y2T_B_8LXB501_0 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	2q22	UNCHARACTERIZED PROTEIN (Trichormus variabilis)	5 / 12	ILE A 125 CYH A 117 GLN A 118 TYR A 77 LEU A 75	None	1.21A	5y2tB-2q22A: undetectable	5y2tB-2q22A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6AY4_A_TPFA506_1 (CYP51, STEROL 14ALPHA-DEMETHYLASE)	2q22	UNCHARACTERIZED PROTEIN (Trichormus variabilis)	5 / 10	PHE A 137 TYR A 71 ALA A 74 LEU A 18 CYH A 117	None	1.35A	6ay4A-2q22A: undetectable	6ay4A-2q22A: 14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H7L_A_Y00A406_1 (BETA-1 ADRENERGIC RECEPTOR)	2q22	UNCHARACTERIZED PROTEIN (Trichormus variabilis)	4 / 6	GLY A 64 LEU A 66 VAL A 115 PHE A 137	None	0.99A	6h7lA-2q22A: undetectable	6h7lA-2q22A: 21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H7L_B_Y00B405_1 (BETA-1 ADRENERGIC RECEPTOR)	2q22	UNCHARACTERIZED PROTEIN (Trichormus variabilis)	4 / 6	GLY A 64 LEU A 66 VAL A 115 PHE A 137	None	0.99A	6h7lB-2q22A: undetectable	6h7lB-2q22A: 21.62

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["5Y2T_B_8LXB501_0","PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA","2q22","UNCHARACTERIZED PROTEIN","Trichormus variabilis",5,"ILE A 125;CYH A 117;GLN A 118;TYR A  77;LEU A  75","None","1.21A","5y2tB-2q22A:undetectable","5y2tB-2q22A:undetectable"],["6AY4_A_TPFA506_1","CYP51, STEROL 14ALPHA-DEMETHYLASE","2q22","UNCHARACTERIZED PROTEIN","Trichormus variabilis",5,"PHE A 137;TYR A  71;ALA A  74;LEU A  18;CYH A 117","None","1.35A","6ay4A-2q22A:undetectable","6ay4A-2q22A:14.42"],["6H7L_A_Y00A406_1","BETA-1 ADRENERGIC RECEPTOR","2q22","UNCHARACTERIZED PROTEIN","Trichormus variabilis",4,"GLY A  64;LEU A  66;VAL A 115;PHE A 137","None","0.99A","6h7lA-2q22A:undetectable","6h7lA-2q22A:21.62"],["6H7L_B_Y00B405_1","BETA-1 ADRENERGIC RECEPTOR","2q22","UNCHARACTERIZED PROTEIN","Trichormus variabilis",4,"GLY A  64;LEU A  66;VAL A 115;PHE A 137","None","0.99A","6h7lB-2q22A:undetectable","6h7lB-2q22A:21.62"]]