SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2q27'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_B_SAMB105_0
(MET REPRESSOR)		 2q27 OXALYL-COA
DECARBOXYLASE
(Escherichia
coli) 		5 / 10 ARG A 501
GLU A 521
HIS A 524
ALA A 525
GLY A 529
 SO4  A2003 ( 3.3A)
None
None
None
None
 1.11A 1cmcA-2q27A:
undetectable
1cmcB-2q27A:
undetectable		 1cmcA-2q27A:
9.69
1cmcB-2q27A:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 2q27 OXALYL-COA
DECARBOXYLASE
(Escherichia
coli) 		5 / 12 ILE A 530
LEU A 522
ARG A 384
ILE A 444
LEU A 391
 None
 0.92A 1drfA-2q27A:
undetectable		 1drfA-2q27A:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F9G_A_ASCA950_0
(HYALURONATE LYASE)		 2q27 OXALYL-COA
DECARBOXYLASE
(Escherichia
coli) 		4 / 7 ASN A  91
TRP A 420
ARG A 158
ASN A  95
 None
 1.46A 1f9gA-2q27A:
undetectable		 1f9gA-2q27A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_1
(HIV-1 PROTEASE)		 2q27 OXALYL-COA
DECARBOXYLASE
(Escherichia
coli) 		6 / 9 GLY A 454
VAL A 467
ILE A 431
GLY A 428
ILE A 425
ILE A 469
 None
 1.31A 1hpvA-2q27A:
undetectable		 1hpvA-2q27A:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 2q27 OXALYL-COA
DECARBOXYLASE
(Escherichia
coli) 		4 / 8 ASN A 473
GLY A 446
THR A 398
GLY A 547
 None
TPP  A3001 (-3.4A)
TPP  A3001 (-3.7A)
None
 0.77A 1jr1B-2q27A:
undetectable		 1jr1B-2q27A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC2199_0
(PROTEIN (METHIONINE
REPRESSOR))		 2q27 OXALYL-COA
DECARBOXYLASE
(Escherichia
coli) 		5 / 12 ALA A 525
GLY A 529
ARG A 501
GLU A 521
HIS A 524
 None
None
SO4  A2003 ( 3.3A)
None
None
 1.22A 1mj2C-2q27A:
undetectable
1mj2D-2q27A:
undetectable		 1mj2C-2q27A:
10.17
1mj2D-2q27A:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_C_SAMC200_0
(METHIONINE REPRESSOR)		 2q27 OXALYL-COA
DECARBOXYLASE
(Escherichia
coli) 		5 / 12 ALA A 525
GLY A 529
ARG A 501
GLU A 521
HIS A 524
 None
None
SO4  A2003 ( 3.3A)
None
None
 1.17A 1mjoC-2q27A:
undetectable
1mjoD-2q27A:
undetectable		 1mjoC-2q27A:
10.17
1mjoD-2q27A:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA501_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 2q27 OXALYL-COA
DECARBOXYLASE
(Escherichia
coli) 		5 / 12 CYH A 461
ASP A 507
GLY A 513
ILE A 469
ALA A 430
 None
 1.29A 1oltA-2q27A:
undetectable		 1oltA-2q27A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS6_A_DXCA75_0
(PPCA)		 2q27 OXALYL-COA
DECARBOXYLASE
(Escherichia
coli) 		4 / 8 ILE A  14
LEU A 147
MET A  99
GLY A  72
 None
 0.97A 1os6A-2q27A:
undetectable		 1os6A-2q27A:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RI4_A_SAMA299_0
(MRNA CAPPING ENZYME)		 2q27 OXALYL-COA
DECARBOXYLASE
(Escherichia
coli) 		5 / 12 GLY A 426
ILE A 431
ALA A  60
PHE A 452
SER A 453
 None
None
None
TPP  A3001 (-4.4A)
None
 1.00A 1ri4A-2q27A:
3.5		 1ri4A-2q27A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_A_GNTA1538_1
(ACETYLCHOLINESTERASE)		 2q27 OXALYL-COA
DECARBOXYLASE
(Escherichia
coli) 		5 / 11 ASP A 416
GLY A 426
GLY A 428
TYR A 429
SER A 453
 None
 1.42A 1w76A-2q27A:
undetectable		 1w76A-2q27A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_A_NCAA506_0
(NAD-DEPENDENT
DEACETYLASE 2)		 2q27 OXALYL-COA
DECARBOXYLASE
(Escherichia
coli) 		4 / 6 ALA A 500
ASN A 473
ILE A 471
ASP A 447
 None
None
None
MG  A1001 ( 2.8A)
 0.94A 1yc2A-2q27A:
13.6		 1yc2A-2q27A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_D_NCAD510_0
(NAD-DEPENDENT
DEACETYLASE 2)		 2q27 OXALYL-COA
DECARBOXYLASE
(Escherichia
coli) 		4 / 5 ALA A 500
ASN A 473
ILE A 471
ASP A 447
 None
None
None
MG  A1001 ( 2.8A)
 0.98A 1yc2D-2q27A:
13.8		 1yc2D-2q27A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_B_VIAB902_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2q27 OXALYL-COA
DECARBOXYLASE
(Escherichia
coli) 		5 / 12 ILE A 240
VAL A 277
ALA A 222
ILE A 251
PHE A 234
 None
 0.94A 2h42B-2q27A:
undetectable		 2h42B-2q27A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H4J_A_NCAA1002_0
(NAD-DEPENDENT
DEACETYLASE)		 2q27 OXALYL-COA
DECARBOXYLASE
(Escherichia
coli) 		4 / 5 ALA A 500
ASN A 473
ILE A 471
ASP A 447
 None
None
None
MG  A1001 ( 2.8A)
 0.89A 2h4jA-2q27A:
12.5		 2h4jA-2q27A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB502_1
(CYTOCHROME P450 2C8)		 2q27 OXALYL-COA
DECARBOXYLASE
(Escherichia
coli) 		5 / 10 ILE A 102
ILE A  26
LEU A  18
ASN A  21
ILE A 151
 None
 1.15A 2nnhB-2q27A:
undetectable		 2nnhB-2q27A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2q27 OXALYL-COA
DECARBOXYLASE
(Escherichia
coli) 		6 / 12 GLY A  96
ASP A 302
LEU A 276
GLY A 278
GLY A 221
LEU A 285
 None
SO4  A2009 (-2.9A)
None
SO4  A2009 ( 4.0A)
EDO  A5002 ( 3.8A)
None
 1.40A 2nxeA-2q27A:
2.4		 2nxeA-2q27A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1002_0
(ALDEHYDE
DEHYDROGENASE A)		 2q27 OXALYL-COA
DECARBOXYLASE
(Escherichia
coli) 		3 / 3 GLY A 547
ARG A 479
TYR A 372
 None
None
TPP  A3001 (-4.4A)
 0.80A 2opxA-2q27A:
undetectable		 2opxA-2q27A:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 2q27 OXALYL-COA
DECARBOXYLASE
(Escherichia
coli) 		3 / 3 ASN A 138
ARG A 136
ASP A 117
 None
 0.98A 2qe6A-2q27A:
3.8		 2qe6A-2q27A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 2q27 OXALYL-COA
DECARBOXYLASE
(Escherichia
coli) 		3 / 3 ASN A 138
ARG A 136
ASP A 117
 None
 0.98A 2qe6B-2q27A:
3.8		 2qe6B-2q27A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_A_FOLA401_0
(DIHYDROFOLATE
REDUCTASE)		 2q27 OXALYL-COA
DECARBOXYLASE
(Escherichia
coli) 		5 / 12 ILE A 530
LEU A 522
ARG A 384
ILE A 444
LEU A 391
 None
 0.89A 2w3bA-2q27A:
undetectable		 2w3bA-2q27A:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		 2q27 OXALYL-COA
DECARBOXYLASE
(Escherichia
coli) 		3 / 3 SER A 364
THR A 367
PHE A 472
 None
 0.71A 2x91A-2q27A:
undetectable		 2x91A-2q27A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_1
(PROTEASE)		 2q27 OXALYL-COA
DECARBOXYLASE
(Escherichia
coli) 		5 / 11 LEU A 505
ILE A 460
GLY A 426
ILE A 537
ILE A 457
 None
 0.77A 3ebzA-2q27A:
undetectable		 3ebzA-2q27A:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB500_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2q27 OXALYL-COA
DECARBOXYLASE
(Escherichia
coli) 		4 / 7 THR A 536
VAL A 470
THR A 468
VAL A 442
 None
 0.56A 3em0B-2q27A:
undetectable		 3em0B-2q27A:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_2
(DIHYDROFOLATE
REDUCTASE)		 2q27 OXALYL-COA
DECARBOXYLASE
(Escherichia
coli) 		4 / 4 ILE A 530
ARG A 414
ILE A 389
THR A 536
 None
 1.23A 3ia4C-2q27A:
undetectable		 3ia4C-2q27A:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IXL_A_PACA5000_0
(ARYLMALONATE
DECARBOXYLASE)		 2q27 OXALYL-COA
DECARBOXYLASE
(Escherichia
coli) 		5 / 10 THR A 436
SER A 437
TYR A 390
VAL A 467
GLY A 432
 None
 1.18A 3ixlA-2q27A:
2.1		 3ixlA-2q27A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 2q27 OXALYL-COA
DECARBOXYLASE
(Escherichia
coli) 		5 / 12 GLY A 395
GLY A 476
ASN A 474
PHE A 472
ILE A 477
 TPP  A3001 (-3.2A)
MG  A1001 ( 4.1A)
MG  A1001 ( 2.7A)
None
TPP  A3001 (-4.4A)
 1.13A 3k13C-2q27A:
undetectable		 3k13C-2q27A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LW5_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 2q27 OXALYL-COA
DECARBOXYLASE
(Escherichia
coli) 		5 / 10 ILE A 314
PHE A 234
SER A 237
ALA A 209
LEU A 208
 None
 1.34A 3lw5B-2q27A:
undetectable		 3lw5B-2q27A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2q27 OXALYL-COA
DECARBOXYLASE
(Escherichia
coli) 		4 / 6 VAL A 162
VAL A 137
ILE A 102
ARG A 152
 None
 0.94A 3ms9A-2q27A:
undetectable		 3ms9A-2q27A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2q27 OXALYL-COA
DECARBOXYLASE
(Escherichia
coli) 		4 / 7 VAL A 162
VAL A 137
ILE A 102
ARG A 152
 None
 0.98A 3ms9B-2q27A:
undetectable		 3ms9B-2q27A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2q27 OXALYL-COA
DECARBOXYLASE
(Escherichia
coli) 		4 / 6 VAL A 162
VAL A 137
ILE A 102
ARG A 152
 None
 0.99A 3mssA-2q27A:
undetectable		 3mssA-2q27A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2q27 OXALYL-COA
DECARBOXYLASE
(Escherichia
coli) 		4 / 6 VAL A 162
VAL A 137
ILE A 102
ARG A 152
 None
 0.96A 3mssC-2q27A:
undetectable		 3mssC-2q27A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 2q27 OXALYL-COA
DECARBOXYLASE
(Escherichia
coli) 		4 / 6 VAL A 162
VAL A 137
ILE A 102
ARG A 152
 None
 1.01A 3pyyA-2q27A:
undetectable		 3pyyA-2q27A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 2q27 OXALYL-COA
DECARBOXYLASE
(Escherichia
coli) 		5 / 12 GLY A 426
GLY A 432
VAL A 441
ALA A  62
PHE A  51
 None
 0.84A 3qowA-2q27A:
undetectable		 3qowA-2q27A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_A_017A201_2
(PROTEASE)		 2q27 OXALYL-COA
DECARBOXYLASE
(Escherichia
coli) 		5 / 11 LEU A 505
ILE A 460
GLY A 426
ILE A 537
ILE A 457
 None
 0.79A 3s53B-2q27A:
undetectable		 3s53B-2q27A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2q27 OXALYL-COA
DECARBOXYLASE
(Escherichia
coli) 		5 / 12 GLN A 141
GLY A  10
ALA A 173
ALA A 168
SER A 105
 None
 1.09A 3sudA-2q27A:
undetectable		 3sudA-2q27A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_D_SAMD300_0
(PUTATIVE
METHYLTRANSFERASE)		 2q27 OXALYL-COA
DECARBOXYLASE
(Escherichia
coli) 		5 / 12 GLY A  58
PHE A  97
MET A  99
GLU A  54
ALA A  88
 None
 1.31A 3t7sD-2q27A:
undetectable		 3t7sD-2q27A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_A_ADNA901_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 2q27 OXALYL-COA
DECARBOXYLASE
(Escherichia
coli) 		5 / 9 ALA A 204
LEU A 208
LEU A 333
ASN A 336
ILE A 240
 None
 1.24A 3wdmA-2q27A:
11.3		 3wdmA-2q27A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_C_ADNC301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 2q27 OXALYL-COA
DECARBOXYLASE
(Escherichia
coli) 		5 / 9 ALA A 204
LEU A 208
LEU A 333
ASN A 336
ILE A 240
 None
 1.20A 3wdmC-2q27A:
11.3		 3wdmC-2q27A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_D_ADND301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 2q27 OXALYL-COA
DECARBOXYLASE
(Escherichia
coli) 		5 / 10 ALA A 204
LEU A 208
LEU A 333
ASN A 336
ILE A 240
 None
 1.12A 3wdmD-2q27A:
11.3		 3wdmD-2q27A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6D_A_SAMA1350_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 2q27 OXALYL-COA
DECARBOXYLASE
(Escherichia
coli) 		5 / 12 LEU A 415
GLY A 428
GLY A 426
ILE A 460
PHE A  51
 None
 1.08A 4a6dA-2q27A:
undetectable		 4a6dA-2q27A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 2q27 OXALYL-COA
DECARBOXYLASE
(Escherichia
coli) 		5 / 12 LEU A 415
GLY A 428
GLY A 426
ILE A 460
PHE A  51
 None
 1.08A 4a6eA-2q27A:
3.1		 4a6eA-2q27A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_B_STRB301_1
(STEROID RECEPTOR 2)		 2q27 OXALYL-COA
DECARBOXYLASE
(Escherichia
coli) 		5 / 12 LEU A  83
LEU A  86
LEU A  89
ALA A  90
TRP A 420
 None
 1.03A 4fn9B-2q27A:
undetectable		 4fn9B-2q27A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 2q27 OXALYL-COA
DECARBOXYLASE
(Escherichia
coli) 		4 / 8 ASN A 473
GLY A 446
THR A 398
GLY A 547
 None
TPP  A3001 (-3.4A)
TPP  A3001 (-3.7A)
None
 0.67A 4fo4B-2q27A:
undetectable		 4fo4B-2q27A:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HAJ_A_DXCA75_0
(PPCA)		 2q27 OXALYL-COA
DECARBOXYLASE
(Escherichia
coli) 		4 / 7 ILE A  14
LEU A 147
MET A  99
GLY A  72
 None
 0.98A 4hajA-2q27A:
undetectable		 4hajA-2q27A:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_D_SVRD301_1
(NUCLEOCAPSID PROTEIN)		 2q27 OXALYL-COA
DECARBOXYLASE
(Escherichia
coli) 		5 / 11 ALA A 248
VAL A 277
MET A 326
PHE A 234
ILE A 240
 None
 1.47A 4j4vD-2q27A:
undetectable
4j4vE-2q27A:
undetectable		 4j4vD-2q27A:
18.74
4j4vE-2q27A:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2q27 OXALYL-COA
DECARBOXYLASE
(Escherichia
coli) 		4 / 5 THR A 340
THR A 339
HIS A 256
ASN A 349
 None
 1.34A 4pgfB-2q27A:
4.5		 4pgfB-2q27A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_B_SAMB301_0
(PUTATIVE RNA
METHYLASE)		 2q27 OXALYL-COA
DECARBOXYLASE
(Escherichia
coli) 		5 / 12 THR A 398
GLY A 395
ASP A 400
ILE A 471
ASN A 397
 TPP  A3001 (-3.7A)
TPP  A3001 (-3.2A)
None
None
TPP  A3001 (-3.9A)
 1.36A 4pooB-2q27A:
3.3		 4pooB-2q27A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 2q27 OXALYL-COA
DECARBOXYLASE
(Escherichia
coli) 		5 / 12 GLY A  28
GLY A  50
ILE A  26
SER A  56
ALA A  57
 None
 1.09A 4qtuD-2q27A:
undetectable		 4qtuD-2q27A:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN)		 2q27 OXALYL-COA
DECARBOXYLASE
(Escherichia
coli) 		5 / 12 SER A 154
GLY A 160
ALA A  60
GLY A  58
TYR A  27
 None
 1.05A 4r29C-2q27A:
undetectable		 4r29C-2q27A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN)		 2q27 OXALYL-COA
DECARBOXYLASE
(Escherichia
coli) 		5 / 12 SER A 154
GLY A 160
ALA A  60
GLY A  58
TYR A  27
 None
 0.98A 4r29D-2q27A:
undetectable		 4r29D-2q27A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTS_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 2q27 OXALYL-COA
DECARBOXYLASE
(Escherichia
coli) 		5 / 12 GLY A 547
GLY A 476
ASP A 447
ILE A 471
ASN A 473
 None
MG  A1001 ( 4.1A)
MG  A1001 ( 2.8A)
None
None
 1.25A 4rtsA-2q27A:
2.7		 4rtsA-2q27A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_A_SAMA1546_0
(CYSTATHIONINE
BETA-SYNTHASE)		 2q27 OXALYL-COA
DECARBOXYLASE
(Escherichia
coli) 		5 / 11 LEU A  67
ALA A 433
THR A  25
ILE A  23
ASP A  24
 None
 1.17A 4uuuA-2q27A:
undetectable
4uuuB-2q27A:
undetectable		 4uuuA-2q27A:
14.01
4uuuB-2q27A:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_B_SAMB1548_0
(CYSTATHIONINE
BETA-SYNTHASE)		 2q27 OXALYL-COA
DECARBOXYLASE
(Escherichia
coli) 		5 / 11 LEU A  67
ALA A 433
THR A  25
ILE A  23
ASP A  24
 None
 1.20A 4uuuB-2q27A:
undetectable		 4uuuB-2q27A:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_1
(PROTEASE)		 2q27 OXALYL-COA
DECARBOXYLASE
(Escherichia
coli) 		5 / 12 LEU A 505
ILE A 460
GLY A 426
ILE A 537
ILE A 457
 None
 0.74A 5e5jA-2q27A:
undetectable		 5e5jA-2q27A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_2
(PROTEASE)		 2q27 OXALYL-COA
DECARBOXYLASE
(Escherichia
coli) 		5 / 12 LEU A 505
ILE A 460
GLY A 426
ILE A 537
ILE A 457
 None
 0.76A 5e5jB-2q27A:
undetectable		 5e5jB-2q27A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5K_B_017B201_2
(HIV-1 PROTEASE)		 2q27 OXALYL-COA
DECARBOXYLASE
(Escherichia
coli) 		5 / 12 LEU A 505
ILE A 460
GLY A 426
ILE A 537
ILE A 457
 None
 0.79A 5e5kB-2q27A:
undetectable		 5e5kB-2q27A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_A_010A609_0
(HNL ISOENZYME 5)		 2q27 OXALYL-COA
DECARBOXYLASE
(Escherichia
coli) 		5 / 11 ALA A 378
ALA A 375
VAL A 540
LEU A 383
VAL A 470
 None
 1.19A 5eb5A-2q27A:
undetectable		 5eb5A-2q27A:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_B_010B607_0
(HNL ISOENZYME 5)		 2q27 OXALYL-COA
DECARBOXYLASE
(Escherichia
coli) 		5 / 10 ALA A 378
ALA A 375
VAL A 540
LEU A 383
VAL A 470
 None
 1.21A 5eb5B-2q27A:
undetectable		 5eb5B-2q27A:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2q27 OXALYL-COA
DECARBOXYLASE
(Escherichia
coli) 		4 / 7 ILE A 431
GLY A 428
LEU A 526
CYH A 461
 None
 0.64A 5hieB-2q27A:
undetectable		 5hieB-2q27A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)		 2q27 OXALYL-COA
DECARBOXYLASE
(Escherichia
coli) 		4 / 7 GLY A 428
PHE A  66
LEU A  67
GLU A 445
 None
 0.79A 5izfA-2q27A:
undetectable		 5izfA-2q27A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)		 2q27 OXALYL-COA
DECARBOXYLASE
(Escherichia
coli) 		3 / 3 LYS A 362
GLN A 354
ASN A 355
 None
SO4  A2006 (-4.5A)
SO4  A2006 (-3.2A)
 1.05A 5l2tA-2q27A:
undetectable		 5l2tA-2q27A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSP_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 2q27 OXALYL-COA
DECARBOXYLASE
(Escherichia
coli) 		4 / 7 VAL A 467
ILE A 469
VAL A 392
ALA A 443
 None
 0.68A 5ospA-2q27A:
undetectable		 5ospA-2q27A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 2q27 OXALYL-COA
DECARBOXYLASE
(Escherichia
coli) 		4 / 7 VAL A 467
ILE A 469
VAL A 392
ALA A 443
 None
 0.69A 5osrA-2q27A:
undetectable		 5osrA-2q27A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V02_R_657R201_0
(CALMODULIN-1
SMALL CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
PROTEIN 2)		 2q27 OXALYL-COA
DECARBOXYLASE
(Escherichia
coli) 		5 / 10 LEU A 383
VAL A 382
LEU A 391
VAL A 470
ILE A 444
 None
 1.12A 5v02B-2q27A:
undetectable
5v02R-2q27A:
undetectable		 5v02B-2q27A:
11.03
5v02R-2q27A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_1
(CYTOCHROME P450 3A5)		 2q27 OXALYL-COA
DECARBOXYLASE
(Escherichia
coli) 		5 / 12 ARG A 414
LEU A 383
ILE A 530
ALA A 433
GLY A 426
 None
 1.08A 5veuA-2q27A:
undetectable		 5veuA-2q27A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_0
(MRNA CAPPING ENZYME
P5)		 2q27 OXALYL-COA
DECARBOXYLASE
(Escherichia
coli) 		5 / 12 LEU A 231
GLY A 278
ALA A 223
GLU A 304
VAL A 319
 None
SO4  A2009 ( 4.0A)
None
None
None
 1.22A 5x6yA-2q27A:
2.8		 5x6yA-2q27A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_1
(SERUM ALBUMIN)		 2q27 OXALYL-COA
DECARBOXYLASE
(Escherichia
coli) 		4 / 5 ASN A 371
VAL A 470
LEU A 526
SER A 377
 None
 1.17A 6a7pA-2q27A:
undetectable		 6a7pA-2q27A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_1
(PROTEIN CYP51)		 2q27 OXALYL-COA
DECARBOXYLASE
(Escherichia
coli) 		5 / 12 ALA A 508
TYR A  27
ALA A  63
ALA A 433
LEU A 465
 None
 1.25A 6aycA-2q27A:
undetectable		 6aycA-2q27A:
9.94