SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2q2e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_B_MTXB171_1
(DIHYDROFOLATE
REDUCTASE)		 2q2e TYPE II DNA
TOPOISOMERASE VI
SUBUNIT A
(Methanosarcina
mazei) 		5 / 12 VAL A 266
ALA A 231
ARG A 236
ARG A 240
GLU A 130
 None
 1.21A 1d1gB-2q2eA:
undetectable		 1d1gB-2q2eA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2q2e TYPE 2 DNA
TOPOISOMERASE 6
SUBUNIT B
(Methanosarcina
mazei) 		5 / 12 ILE B 277
CYH B 278
ALA B 280
ALA B 281
PHE B 304
 None
 1.08A 1fbyA-2q2eB:
undetectable		 1fbyA-2q2eB:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_B_9CRB1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2q2e TYPE 2 DNA
TOPOISOMERASE 6
SUBUNIT B
(Methanosarcina
mazei) 		5 / 12 ILE B 277
CYH B 278
ALA B 280
ALA B 281
PHE B 304
 None
 1.07A 1fbyB-2q2eB:
undetectable		 1fbyB-2q2eB:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_F_REAF177_1
(RETINOL BINDING
PROTEIN)		 2q2e TYPE 2 DNA
TOPOISOMERASE 6
SUBUNIT B
(Methanosarcina
mazei) 		5 / 11 LEU B  50
ALA B 223
ALA B 206
VAL B  46
LEU B 196
 None
 1.13A 1rlbF-2q2eB:
undetectable		 1rlbF-2q2eB:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_1
(POL POLYPROTEIN)		 2q2e TYPE 2 DNA
TOPOISOMERASE 6
SUBUNIT B
(Methanosarcina
mazei) 		5 / 8 ALA B 424
ILE B 320
GLY B 321
PRO B 230
ALA B 231
 None
 1.19A 1sguA-2q2eB:
undetectable		 1sguA-2q2eB:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_A_9CRA201_1
(RXR-LIKE PROTEIN)		 2q2e TYPE 2 DNA
TOPOISOMERASE 6
SUBUNIT B
(Methanosarcina
mazei) 		5 / 12 ILE B 277
CYH B 278
ALA B 280
ALA B 281
PHE B 304
 None
 0.97A 1xiuA-2q2eB:
undetectable		 1xiuA-2q2eB:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		 2q2e TYPE II DNA
TOPOISOMERASE VI
SUBUNIT A
(Methanosarcina
mazei) 		4 / 7 PRO A 257
GLY A 338
LEU A 313
PRO A 292
 None
 0.88A 1ya4B-2q2eA:
2.8		 1ya4B-2q2eA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1294_1
(FICOLIN-2)		 2q2e TYPE 2 DNA
TOPOISOMERASE 6
SUBUNIT B
(Methanosarcina
mazei) 		5 / 9 VAL B 380
GLY B 111
ASP B  51
ASP B  47
GLU B  54
 None
 1.38A 2j2pB-2q2eB:
undetectable
2j2pC-2q2eB:
undetectable		 2j2pB-2q2eB:
16.19
2j2pC-2q2eB:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 2q2e TYPE 2 DNA
TOPOISOMERASE 6
SUBUNIT B
(Methanosarcina
mazei) 		5 / 12 VAL B 335
PHE B 337
VAL B 455
GLY B 358
ALA B 339
 None
 1.04A 2x2iA-2q2eB:
undetectable		 2x2iA-2q2eB:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 2q2e TYPE 2 DNA
TOPOISOMERASE 6
SUBUNIT B
(Methanosarcina
mazei) 		5 / 12 VAL B 335
PHE B 337
VAL B 455
GLY B 358
ALA B 339
 None
 1.10A 2x2iC-2q2eB:
undetectable		 2x2iC-2q2eB:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 2q2e TYPE II DNA
TOPOISOMERASE VI
SUBUNIT A
(Methanosarcina
mazei) 		5 / 12 TYR A 139
ILE A 181
ILE A 157
GLU A 189
ARG A 236
 None
 1.14A 3fpjB-2q2eA:
undetectable		 3fpjB-2q2eA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP9_D_SPMD230_1
(LS-24)		 2q2e TYPE II DNA
TOPOISOMERASE VI
SUBUNIT A
(Methanosarcina
mazei) 		3 / 3 GLU A 159
GLU A 186
ASN A 184
 None
 0.89A 3lp9B-2q2eA:
undetectable
3lp9D-2q2eA:
undetectable		 3lp9B-2q2eA:
21.10
3lp9D-2q2eA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A2000_1
(P38A)		 2q2e TYPE 2 DNA
TOPOISOMERASE 6
SUBUNIT B
(Methanosarcina
mazei) 		5 / 12 ASP B  47
ILE B 117
ILE B 211
ILE B 176
ALA B  49
 None
 1.19A 3ohtA-2q2eB:
undetectable
3ohtB-2q2eB:
undetectable		 3ohtA-2q2eB:
20.13
3ohtB-2q2eB:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2q2e TYPE 2 DNA
TOPOISOMERASE 6
SUBUNIT B
(Methanosarcina
mazei) 		5 / 12 GLY B 404
VAL B 414
PHE B 337
ALA B 339
SER B 341
 None
 1.01A 3sudD-2q2eB:
undetectable		 3sudD-2q2eB:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_1
(GLYCINE
N-METHYLTRANSFERASE)		 2q2e TYPE 2 DNA
TOPOISOMERASE 6
SUBUNIT B
(Methanosarcina
mazei) 		3 / 3 LEU B 161
HIS B 131
MET B 150
 None
 0.94A 3thrD-2q2eB:
undetectable		 3thrD-2q2eB:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_A_CYZA266_2
(GLUTAMATE RECEPTOR 2)		 2q2e TYPE 2 DNA
TOPOISOMERASE 6
SUBUNIT B
(Methanosarcina
mazei) 		4 / 5 ILE B 320
PRO B 319
SER B 341
GLY B 321
 None
 1.11A 3tkdB-2q2eB:
undetectable		 3tkdB-2q2eB:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_B_CYZB267_1
(GLUTAMATE RECEPTOR 2)		 2q2e TYPE 2 DNA
TOPOISOMERASE 6
SUBUNIT B
(Methanosarcina
mazei) 		4 / 5 ILE B 320
PRO B 319
SER B 341
GLY B 321
 None
 1.12A 3tkdA-2q2eB:
undetectable		 3tkdA-2q2eB:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_B_DXCB1473_0
(MJ0495-LIKE PROTEIN)		 2q2e TYPE 2 DNA
TOPOISOMERASE 6
SUBUNIT B
(Methanosarcina
mazei) 		5 / 11 ILE B 448
ILE B 444
VAL B 428
SER B 318
ARG B 379
 None
 1.02A 4ac9B-2q2eB:
undetectable
4ac9C-2q2eB:
undetectable		 4ac9B-2q2eB:
24.07
4ac9C-2q2eB:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1475_0
(MJ0495-LIKE PROTEIN)		 2q2e TYPE 2 DNA
TOPOISOMERASE 6
SUBUNIT B
(Methanosarcina
mazei) 		4 / 8 ILE B 208
ASP B  61
ILE B  62
VAL B  42
 None
 0.82A 4ac9C-2q2eB:
undetectable		 4ac9C-2q2eB:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2q2e TYPE II DNA
TOPOISOMERASE VI
SUBUNIT A
(Methanosarcina
mazei) 		3 / 3 TYR A  28
THR A  82
GLU A  91
 None
 0.65A 4df3A-2q2eA:
undetectable		 4df3A-2q2eA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2q2e TYPE II DNA
TOPOISOMERASE VI
SUBUNIT A
(Methanosarcina
mazei) 		3 / 3 TYR A  28
THR A  82
GLU A  91
 None
 0.62A 4df3B-2q2eA:
undetectable		 4df3B-2q2eA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4II8_A_010A210_0
(LYSOZYME C)		 2q2e TYPE 2 DNA
TOPOISOMERASE 6
SUBUNIT B
(Methanosarcina
mazei) 		4 / 7 GLU B  54
ASP B  51
ASN B  48
ILE B  62
 None
 1.17A 4ii8A-2q2eB:
undetectable		 4ii8A-2q2eB:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_A_ACTA502_0
(RNA-DEPENDENT RNA
POLYMERASE)		 2q2e TYPE 2 DNA
TOPOISOMERASE 6
SUBUNIT B
(Methanosarcina
mazei) 		4 / 5 LYS B 299
LEU B 300
GLU B 296
LEU B 283
 None
 1.06A 4k4yA-2q2eB:
undetectable		 4k4yA-2q2eB:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_I_ACTI503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 2q2e TYPE 2 DNA
TOPOISOMERASE 6
SUBUNIT B
(Methanosarcina
mazei) 		4 / 5 LYS B 299
LEU B 300
GLU B 296
LEU B 283
 None
 1.04A 4k4yI-2q2eB:
undetectable		 4k4yI-2q2eB:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_1
(METHYLTRANSFERASE
MPPJ)		 2q2e TYPE II DNA
TOPOISOMERASE VI
SUBUNIT A
(Methanosarcina
mazei) 		3 / 3 ARG A 261
ASP A 309
ASP A 303
 None
 0.89A 4kicB-2q2eA:
undetectable		 4kicB-2q2eA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_2
(MDR769 HIV-1
PROTEASE)		 2q2e TYPE 2 DNA
TOPOISOMERASE 6
SUBUNIT B
(Methanosarcina
mazei) 		4 / 6 ARG B 181
ASP B 212
GLY B 187
PRO B  35
 None
 1.05A 4l1aB-2q2eB:
undetectable		 4l1aB-2q2eB:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_ADNA2414_1
(RNA-DIRECTED RNA
POLYMERASE L)		 2q2e TYPE 2 DNA
TOPOISOMERASE 6
SUBUNIT B
(Methanosarcina
mazei) 		4 / 6 GLU B 239
PHE B 304
PHE B 266
HIS B 237
 None
 1.39A 4uciA-2q2eB:
undetectable		 4uciA-2q2eB:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_ADNB2415_1
(RNA-DIRECTED RNA
POLYMERASE L)		 2q2e TYPE 2 DNA
TOPOISOMERASE 6
SUBUNIT B
(Methanosarcina
mazei) 		4 / 7 GLU B 239
PHE B 304
PHE B 266
HIS B 237
 None
 1.31A 4uciB-2q2eB:
undetectable		 4uciB-2q2eB:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA305_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 2q2e TYPE II DNA
TOPOISOMERASE VI
SUBUNIT A
(Methanosarcina
mazei) 		4 / 6 LEU A  20
GLU A  25
ASN A  90
ILE A  89
 None
 0.91A 4ww7A-2q2eA:
undetectable		 4ww7A-2q2eA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_A_MZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2q2e TYPE 2 DNA
TOPOISOMERASE 6
SUBUNIT B
(Methanosarcina
mazei) 		5 / 12 ASP B 212
VAL B  66
VAL B  76
LEU B  38
THR B  41
 None
 1.39A 4yhaA-2q2eB:
undetectable		 4yhaA-2q2eB:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_A_PAUA302_0
(TYPE III
PANTOTHENATE KINASE)		 2q2e TYPE 2 DNA
TOPOISOMERASE 6
SUBUNIT B
(Methanosarcina
mazei) 		5 / 12 GLY B 387
THR B 431
GLN B 386
LEU B 382
THR B 391
 None
 1.29A 5b8hA-2q2eB:
undetectable
5b8hB-2q2eB:
undetectable		 5b8hA-2q2eB:
19.45
5b8hB-2q2eB:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NR3_A_95EA401_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3B)		 2q2e TYPE 2 DNA
TOPOISOMERASE 6
SUBUNIT B
(Methanosarcina
mazei) 		4 / 7 ILE B 117
PHE B  94
ASP B  80
SER B 136
 None
 1.34A 5nr3A-2q2eB:
undetectable		 5nr3A-2q2eB:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 2q2e TYPE 2 DNA
TOPOISOMERASE 6
SUBUNIT B
(Methanosarcina
mazei) 		4 / 5 PHE B 304
THR B 273
GLU B 239
ASN B 351
 None
 1.49A 5ybbA-2q2eB:
undetectable		 5ybbA-2q2eB:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_1
(SERUM ALBUMIN)		 2q2e TYPE 2 DNA
TOPOISOMERASE 6
SUBUNIT B
(Methanosarcina
mazei) 		4 / 5 ASN B 203
VAL B 354
LEU B 317
SER B 109
 None
 1.11A 6a7pA-2q2eB:
undetectable		 6a7pA-2q2eB:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA608_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 2q2e TYPE 2 DNA
TOPOISOMERASE 6
SUBUNIT B
(Methanosarcina
mazei) 		3 / 3 GLY B 388
THR B 392
GLU B 396
 None
 0.54A 6b58A-2q2eB:
undetectable		 6b58A-2q2eB:
23.14