SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2q2r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A27_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 2q2r GLUCOKINASE 1,
PUTATIVE
(Trypanosoma
cruzi) 		5 / 12 VAL A 305
GLY A 306
ASN A 353
VAL A 142
PHE A 152
 None
 1.42A 1a27A-2q2rA:
undetectable		 1a27A-2q2rA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4001_1
(SERUM ALBUMIN)		 2q2r GLUCOKINASE 1,
PUTATIVE
(Trypanosoma
cruzi) 		5 / 9 LEU A 132
LEU A 304
VAL A 289
GLY A 290
LEU A 187
 BGC  A1001 ( 4.8A)
None
None
None
None
 1.12A 1e7aB-2q2rA:
1.7		 1e7aB-2q2rA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_D_ESTD352_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 2q2r GLUCOKINASE 1,
PUTATIVE
(Trypanosoma
cruzi) 		4 / 6 VAL A 289
GLY A 290
LEU A 179
TYR A 345
 None
 1.04A 1fduD-2q2rA:
undetectable		 1fduD-2q2rA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HMY_A_SAMA328_0
(HAEIII
METHYLTRANSFERASE)		 2q2r GLUCOKINASE 1,
PUTATIVE
(Trypanosoma
cruzi) 		4 / 8 PHE A 104
ASP A  61
ILE A  62
THR A  63
 None
 0.62A 1hmyA-2q2rA:
undetectable		 1hmyA-2q2rA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2q2r GLUCOKINASE 1,
PUTATIVE
(Trypanosoma
cruzi) 		4 / 5 GLY A 209
GLN A 211
VAL A 289
SER A 189
 None
 1.14A 1zzqB-2q2rA:
undetectable		 1zzqB-2q2rA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2q2r GLUCOKINASE 1,
PUTATIVE
(Trypanosoma
cruzi) 		4 / 5 GLY A 209
GLN A 211
VAL A 289
SER A 189
 None
 1.17A 1zzuA-2q2rA:
undetectable		 1zzuA-2q2rA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2q2r GLUCOKINASE 1,
PUTATIVE
(Trypanosoma
cruzi) 		5 / 8 ARG A  83
LEU A  24
PHE A  26
PHE A  39
LEU A  15
 None
 1.44A 2eilP-2q2rA:
undetectable
2eilW-2q2rA:
undetectable		 2eilP-2q2rA:
21.78
2eilW-2q2rA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2q2r GLUCOKINASE 1,
PUTATIVE
(Trypanosoma
cruzi) 		4 / 6 ARG A  83
LEU A  24
PHE A  26
LEU A  15
 None
 1.02A 2einP-2q2rA:
undetectable
2einW-2q2rA:
undetectable		 2einP-2q2rA:
21.78
2einW-2q2rA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F81_A_017A302_1
(POL POLYPROTEIN)		 2q2r GLUCOKINASE 1,
PUTATIVE
(Trypanosoma
cruzi) 		5 / 12 LEU A 179
GLY A 188
ASP A 131
GLY A 306
ILE A 309
 None
BGC  A1001 (-3.5A)
BGC  A1001 (-3.0A)
None
None
 0.98A 2f81A-2q2rA:
undetectable		 2f81A-2q2rA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_1
(POL PROTEIN)		 2q2r GLUCOKINASE 1,
PUTATIVE
(Trypanosoma
cruzi) 		5 / 11 LEU A 179
GLY A 188
ASP A 131
GLY A 306
ILE A 309
 None
BGC  A1001 (-3.5A)
BGC  A1001 (-3.0A)
None
None
 0.95A 2fxdA-2q2rA:
undetectable		 2fxdA-2q2rA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_A_017A201_1
(PROTEASE)		 2q2r GLUCOKINASE 1,
PUTATIVE
(Trypanosoma
cruzi) 		5 / 12 LEU A 179
GLY A 188
ASP A 131
GLY A 306
ILE A 309
 None
BGC  A1001 (-3.5A)
BGC  A1001 (-3.0A)
None
None
 0.98A 2hs2A-2q2rA:
undetectable		 2hs2A-2q2rA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_A_017A201_2
(PROTEASE)		 2q2r GLUCOKINASE 1,
PUTATIVE
(Trypanosoma
cruzi) 		5 / 12 LEU A 179
GLY A 188
ASP A 131
GLY A 306
ILE A 309
 None
BGC  A1001 (-3.5A)
BGC  A1001 (-3.0A)
None
None
 0.95A 2hs2B-2q2rA:
undetectable		 2hs2B-2q2rA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_B_LDPB502_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 2q2r GLUCOKINASE 1,
PUTATIVE
(Trypanosoma
cruzi) 		4 / 5 GLN A 348
PHE A 152
PHE A 148
GLY A 136
 None
 1.40A 2qmzA-2q2rA:
undetectable
2qmzB-2q2rA:
undetectable		 2qmzA-2q2rA:
21.43
2qmzB-2q2rA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2q2r GLUCOKINASE 1,
PUTATIVE
(Trypanosoma
cruzi) 		5 / 6 ARG A  83
LEU A  24
PHE A  26
PHE A  39
LEU A  15
 None
 1.42A 3abkP-2q2rA:
undetectable
3abkW-2q2rA:
undetectable		 3abkP-2q2rA:
21.78
3abkW-2q2rA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 2q2r GLUCOKINASE 1,
PUTATIVE
(Trypanosoma
cruzi) 		5 / 8 ARG A  83
LEU A  24
PHE A  26
PHE A  39
LEU A  15
 None
 1.43A 3asoC-2q2rA:
undetectable
3asoJ-2q2rA:
undetectable		 3asoC-2q2rA:
21.78
3asoJ-2q2rA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_B_017B200_1
(PROTEASE)		 2q2r GLUCOKINASE 1,
PUTATIVE
(Trypanosoma
cruzi) 		5 / 9 LEU A 179
GLY A 188
ASP A 131
GLY A 306
ILE A 309
 None
BGC  A1001 (-3.5A)
BGC  A1001 (-3.0A)
None
None
 1.02A 3ektA-2q2rA:
undetectable		 3ektA-2q2rA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GGU_B_017B201_2
(PROTEASE)		 2q2r GLUCOKINASE 1,
PUTATIVE
(Trypanosoma
cruzi) 		5 / 9 LEU A 179
GLY A 188
ASP A 131
GLY A 306
ILE A 309
 None
BGC  A1001 (-3.5A)
BGC  A1001 (-3.0A)
None
None
 0.98A 3gguB-2q2rA:
undetectable		 3gguB-2q2rA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 2q2r GLUCOKINASE 1,
PUTATIVE
(Trypanosoma
cruzi) 		5 / 12 GLY A  32
THR A 185
SER A  56
ILE A  62
THR A  63
 None
ADP  A2001 (-3.3A)
None
None
None
 1.19A 3iv6A-2q2rA:
undetectable		 3iv6A-2q2rA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MWS_B_017B201_1
(HIV-1 PROTEASE)		 2q2r GLUCOKINASE 1,
PUTATIVE
(Trypanosoma
cruzi) 		5 / 12 LEU A 179
GLY A 188
ASP A 131
GLY A 306
ILE A 309
 None
BGC  A1001 (-3.5A)
BGC  A1001 (-3.0A)
None
None
 0.96A 3mwsA-2q2rA:
undetectable		 3mwsA-2q2rA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_D_MTXD2000_2
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 2q2r GLUCOKINASE 1,
PUTATIVE
(Trypanosoma
cruzi) 		3 / 3 LEU A 107
ARG A  54
ASN A 355
 None
 0.56A 3qxvD-2q2rA:
undetectable		 3qxvD-2q2rA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2q2r GLUCOKINASE 1,
PUTATIVE
(Trypanosoma
cruzi) 		5 / 6 ARG A  83
LEU A  24
PHE A  26
PHE A  39
LEU A  15
 None
 1.39A 3wg7P-2q2rA:
undetectable
3wg7W-2q2rA:
undetectable		 3wg7P-2q2rA:
21.78
3wg7W-2q2rA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_2
(ASPARTYL PROTEASE)		 2q2r GLUCOKINASE 1,
PUTATIVE
(Trypanosoma
cruzi) 		5 / 9 LEU A 179
GLY A 188
ASP A 131
GLY A 306
ILE A 309
 None
BGC  A1001 (-3.5A)
BGC  A1001 (-3.0A)
None
None
 1.05A 4dqcB-2q2rA:
undetectable		 4dqcB-2q2rA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A602_1
(SERUM ALBUMIN)		 2q2r GLUCOKINASE 1,
PUTATIVE
(Trypanosoma
cruzi) 		4 / 7 VAL A  52
MET A  37
PHE A  26
TYR A 116
 None
 1.05A 4lb2A-2q2rA:
undetectable		 4lb2A-2q2rA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2q2r GLUCOKINASE 1,
PUTATIVE
(Trypanosoma
cruzi) 		4 / 8 PRO A  77
SER A  79
VAL A  80
ARG A  83
 None
 0.87A 4mk4A-2q2rA:
undetectable		 4mk4A-2q2rA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_B_017B101_2
(PROTEASE)		 2q2r GLUCOKINASE 1,
PUTATIVE
(Trypanosoma
cruzi) 		5 / 10 LEU A 179
GLY A 188
ASP A 131
GLY A 306
ILE A 309
 None
BGC  A1001 (-3.5A)
BGC  A1001 (-3.0A)
None
None
 1.00A 4njtB-2q2rA:
undetectable		 4njtB-2q2rA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_2
(ANDROGEN RECEPTOR)		 2q2r GLUCOKINASE 1,
PUTATIVE
(Trypanosoma
cruzi) 		4 / 6 MET A  81
MET A  76
LEU A  11
ILE A   3
 None
 1.10A 4okxA-2q2rA:
undetectable		 4okxA-2q2rA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP6_A_B40A601_1
(TRANSPORTER)		 2q2r GLUCOKINASE 1,
PUTATIVE
(Trypanosoma
cruzi) 		4 / 5 ASP A  61
VAL A  30
PHE A 104
GLY A  32
 None
 1.10A 4xp6A-2q2rA:
undetectable		 4xp6A-2q2rA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2q2r GLUCOKINASE 1,
PUTATIVE
(Trypanosoma
cruzi) 		5 / 7 ARG A  83
LEU A  24
PHE A  26
PHE A  39
LEU A  15
 None
 1.42A 5b1aC-2q2rA:
undetectable
5b1aJ-2q2rA:
undetectable		 5b1aC-2q2rA:
21.78
5b1aJ-2q2rA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2q2r GLUCOKINASE 1,
PUTATIVE
(Trypanosoma
cruzi) 		5 / 7 ARG A  83
LEU A  24
PHE A  26
PHE A  39
LEU A  15
 None
 1.36A 5b1aP-2q2rA:
undetectable
5b1aW-2q2rA:
undetectable		 5b1aP-2q2rA:
21.78
5b1aW-2q2rA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2q2r GLUCOKINASE 1,
PUTATIVE
(Trypanosoma
cruzi) 		5 / 7 ARG A  83
LEU A  24
PHE A  26
PHE A  39
LEU A  15
 None
 1.40A 5b3sC-2q2rA:
undetectable
5b3sJ-2q2rA:
undetectable		 5b3sC-2q2rA:
21.78
5b3sJ-2q2rA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 2q2r GLUCOKINASE 1,
PUTATIVE
(Trypanosoma
cruzi) 		5 / 7 ARG A  83
LEU A  24
PHE A  26
PHE A  39
LEU A  15
 None
 1.40A 5b3sP-2q2rA:
undetectable		 5b3sP-2q2rA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 2q2r GLUCOKINASE 1,
PUTATIVE
(Trypanosoma
cruzi) 		5 / 12 ALA A 111
GLY A  93
GLY A 101
GLY A  98
GLU A 236
 None
BGC  A1001 (-3.1A)
None
None
BGC  A1001 (-2.6A)
 0.98A 5c0oG-2q2rA:
undetectable		 5c0oG-2q2rA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2q2r GLUCOKINASE 1,
PUTATIVE
(Trypanosoma
cruzi) 		4 / 4 LEU A 208
TYR A 193
PRO A 299
ILE A 302
 None
 1.36A 5esgA-2q2rA:
undetectable		 5esgA-2q2rA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA605_1
(CHITINASE)		 2q2r GLUCOKINASE 1,
PUTATIVE
(Trypanosoma
cruzi) 		3 / 3 TRP A 156
ILE A 302
SER A 294
 None
 1.02A 5gqbA-2q2rA:
undetectable		 5gqbA-2q2rA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_1
(CDL2.3A)		 2q2r GLUCOKINASE 1,
PUTATIVE
(Trypanosoma
cruzi) 		5 / 12 LEU A 120
PHE A 121
PHE A  69
PHE A  68
ALA A  35
 None
 1.37A 5ieoA-2q2rA:
undetectable		 5ieoA-2q2rA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2q2r GLUCOKINASE 1,
PUTATIVE
(Trypanosoma
cruzi) 		5 / 7 ARG A  83
LEU A  24
PHE A  26
PHE A  39
LEU A  15
 None
 1.42A 5iy5C-2q2rA:
undetectable
5iy5J-2q2rA:
undetectable		 5iy5C-2q2rA:
22.05
5iy5J-2q2rA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2q2r GLUCOKINASE 1,
PUTATIVE
(Trypanosoma
cruzi) 		4 / 5 ARG A  83
LEU A  24
PHE A  26
LEU A  15
 None
 1.02A 5iy5P-2q2rA:
undetectable
5iy5W-2q2rA:
undetectable		 5iy5P-2q2rA:
22.05
5iy5W-2q2rA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_1
(SCRFP-TAG,GP41)		 2q2r GLUCOKINASE 1,
PUTATIVE
(Trypanosoma
cruzi) 		5 / 12 LEU A 244
GLY A 241
SER A 240
ASN A 308
LEU A 187
 None
ADP  A2001 (-3.2A)
None
ADP  A2001 (-3.3A)
None
 1.27A 5nwvA-2q2rA:
undetectable		 5nwvA-2q2rA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2q2r GLUCOKINASE 1,
PUTATIVE
(Trypanosoma
cruzi) 		4 / 6 ARG A  83
LEU A  24
PHE A  26
LEU A  15
 None
 1.04A 5w97C-2q2rA:
undetectable
5w97J-2q2rA:
undetectable		 5w97C-2q2rA:
21.78
5w97J-2q2rA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 2q2r GLUCOKINASE 1,
PUTATIVE
(Trypanosoma
cruzi) 		4 / 5 ARG A  83
LEU A  24
PHE A  26
LEU A  15
 None
 1.09A 5x1bP-2q2rA:
undetectable		 5x1bP-2q2rA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2q2r GLUCOKINASE 1,
PUTATIVE
(Trypanosoma
cruzi) 		4 / 5 ARG A  83
LEU A  24
PHE A  26
LEU A  15
 None
 1.13A 5x1fC-2q2rA:
undetectable
5x1fJ-2q2rA:
undetectable		 5x1fC-2q2rA:
21.78
5x1fJ-2q2rA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 2q2r GLUCOKINASE 1,
PUTATIVE
(Trypanosoma
cruzi) 		4 / 5 ARG A  83
LEU A  24
PHE A  26
LEU A  15
 None
 1.02A 5xdxC-2q2rA:
undetectable
5xdxJ-2q2rA:
undetectable		 5xdxC-2q2rA:
21.58
5xdxJ-2q2rA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 2q2r GLUCOKINASE 1,
PUTATIVE
(Trypanosoma
cruzi) 		4 / 5 ARG A  83
LEU A  24
PHE A  26
LEU A  15
 None
 1.04A 5xdxP-2q2rA:
undetectable
5xdxW-2q2rA:
undetectable		 5xdxP-2q2rA:
21.58
5xdxW-2q2rA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2q2r GLUCOKINASE 1,
PUTATIVE
(Trypanosoma
cruzi) 		5 / 7 ARG A  83
LEU A  24
PHE A  26
PHE A  39
LEU A  15
 None
 1.41A 5z84C-2q2rA:
undetectable
5z84J-2q2rA:
undetectable		 5z84C-2q2rA:
21.78
5z84J-2q2rA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C79_A_CE3A301_1
(BETA-LACTAMASE
TOHO-1)		 2q2r GLUCOKINASE 1,
PUTATIVE
(Trypanosoma
cruzi) 		5 / 12 ALA A 242
ASN A 234
ASN A 237
GLY A 241
GLY A 186
 None
None
None
ADP  A2001 (-3.2A)
BGC  A1001 (-3.6A)
 1.14A 6c79A-2q2rA:
undetectable		 6c79A-2q2rA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_2
(-)		 2q2r GLUCOKINASE 1,
PUTATIVE
(Trypanosoma
cruzi) 		4 / 8 VAL A 147
TYR A 151
HIS A   0
GLU A  42
 None
 1.22A 6gneB-2q2rA:
undetectable		 6gneB-2q2rA:
21.14